Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate

Product Name: Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate
CAS No.: 6386-38-5
Chemical Name: Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate
Synonyms: Metilox;3,5-Methyl Ester;ralox35;Methyl 3-(3;Methyl 3-(3,5-di-ter;Propofol Impurity 35;Propofol Related Compound 3;3,5-di-tert-butyl-4-hydroxyphenyl;METHYL DI-t-BUTYL HYDROXYHYDROCINNAMATE;methyl di-tert-butyl hydroxyhydrocinnamate
CBNumber: CB3475740
Molecular Formula: C18H28O3
Formula Weight: 292.41
MOL File: 6386-38-5.mol

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Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate Property

Melting point:: 60-67°C
Boiling point:: 125-130 °C(Press: 0.1 Torr)
Density: 1.006±0.06 g/cm3(Predicted)
refractive index: 1.5034
storage temp.: Inert atmosphere,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 12.17±0.40(Predicted)
color: White to Almost white
Water Solubility: 2.2mg/L at 20℃
InChI: InChI=1S/C18H28O3/c1-17(2,3)13-10-12(8-9-15(19)21-7)11-14(16(13)20)18(4,5)6/h10-11,20H,8-9H2,1-7H3
InChIKey: PXMJCECEFTYEKE-UHFFFAOYSA-N
SMILES: C1(CCC(OC)=O)=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1
LogP: 4.866 (est)
CAS DataBase Reference: 6386-38-5(CAS DataBase Reference)
EPA Substance Registry System: Methyl 3,5-bis(tert-butyl)-4-hydroxyhydrocinnamate (6386-38-5)

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
HazardClass: IRRITANT
HS Code: 2918290090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: M1810
Product name: Methyl 3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionate
Packaging: 5G
Price: $20
Updated: 2025/07/31

TCI Chemical

Product number: M1810
Product name: Methyl 3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionate
Packaging: 25G
Price: $44
Updated: 2025/07/31

TRC

Product number: M301178
Product name: Methyl 3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionate
Packaging: 50g
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD70028
Product name: 3,5-di-tert-Butyl-4-hydroxyphenylpropionic acid methyl ester
Packaging: 100g
Price: $120
Updated: 2021/12/16

Matrix Scientific

Product number: 045916
Product name: Methyl 3-[3,5-di(tert-butyl)-4-hydroxyphenyl]-propanoate
Purity: 95+%
Packaging: 100g
Price: $130
Updated: 2021/12/16

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Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate Chemical Properties,Usage,Production

Uses

Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate is an antioxidant that is used in polyethylene.

Definition

ChEBI: Benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, methyl ester is an alkylbenzene.

Synthesis

128-39-2

292638-85-8

6386-38-5

(1) 2,6-di-tert-butylphenol (20.6 g), zinc carbonate (mass ratio 1.5) and tributyltin acetate (0.072 g) were added to a three-necked flask fitted with a mechanical stirrer, a nitrogen introduction tube and a dropping funnel under nitrogen atmosphere. The mixture was melted under nitrogen protection and heating conditions to form a reaction system. (2) When the temperature of the reaction system rose to 70°C, methyl acrylate (8.24 g) was slowly added through a dropping funnel. After the dropwise addition was completed, the reaction was continued with stirring for 0.5 hours. The reaction temperature was then raised to 90 °C and maintained for 1 hour. After completion of the reaction, it was cooled to 80 °C and the reaction solution was adjusted to neutral with dilute hydrochloric acid to induce crystallization of the product. After filtration, methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate was obtained in 99% yield and 99.5% purity without recrystallization.

References

[1] Patent: CN108358781, 2018, A. Location in patent: Paragraph 0046-0049
[2] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1989, vol. 38, # 8.2, p. 1677 - 1682
[3] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1989, # 8, p. 1829 - 1835
[4] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1989, vol. 38, # 8.2, p. 1677 - 1682
[5] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1989, # 8, p. 1829 - 1835

Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate Suppliers

Americas 1 China 149 Europe 2 France 1 Germany 2 India 5 Japan 1 Slovakia 1 United Kingdom 7 United States 14 USA 1 Global 184

XiaoGan ShenYuan ChemPharm co,ltd

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Energy Chemical

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View Lastest Price from Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 3,5-di-tert-butyl-4-hydroxyphenyl 6386-38-5
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-12-16

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3,5-di-tert-butyl-4-hydroxyphenyl 6386-38-5
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-25

Hebei Yanxi Chemical Co., Ltd.

Product: 3,5-di-tert-butyl-4-hydroxyphenyl 6386-38-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-11-21

6386-38-5, Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionateRelated Search:

Kresoxim-methyl Methanol Butylated hydroxyanisole Methyl propionate Butylated Hydroxytoluene METSULFURON METHYL tert-Butylchlorodiphenylsilane Methyl acrylate Methyl cellulose Bensulfuron methyl Methyl 3,5-dihydroxybenzoate Calcium Propionate Methylparaben Di-tert-butyl peroxide Methyl Methyl bromide Antioxidant 1035 Antioxidant 1010

3,5-DI-TERT-BUTYL-4-HYDROXYPHENYLPROPIONIC ACID METHYL ESTER

Benzenepropanoicacid,3,5-bis(1,1-dimethylethyl)-4-hydroxy-,methylester

Hydrocinnamicacid,3,5-di-tert-butyl-4-hydroxy-,methylester

ralox35

METHYL 3,5-DI-TERT-BUTYL-4-HYDROXYHYDROCINNAMATE

METHYL 3,5-DI-TERT-BUTYL-4-HYDROXYPHENYLPROPIONATE

METHYL 3-[3,5-DI(TERT-BUTYL)-4-HYDROXYPHENYL]PROPANOATE

METHYL 3-(3,5-DI-TERT-BUTYL-4-HYDROXYPHENYL)PROPIONATE

3,5-Methyl Ester

3,5-Bis(1,1-dimethylethyl)-4-hydroxybenzenepropanoic acid methyl ester

3-(3,5-DI-TERT-BUTYL-4-HYDROXY-PHENYL)-PROPIONIC ACID METHYL ESTER

Methyl 3-(3,5-tertbutyl-4-hydroxyphenyl)propionate

3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXYBENZENEPROPIONIC ACID METHYL ESTER

Methyl-3(3,5-di-tert.-butyl-4-hydroxyphenyl)propionat

3,5-bis(1,1-dimethylethyl)-4-hydroxy-, methyl ester

3-(3,5-Ditert-butyl-4-hydroxyphenyl)propanoic acid methyl ester

3-(4-Hydroxy-3,5-di-tert-butylphenyl)propanoic acid methyl ester

3-(4-Hydroxy-3,5-di-tert-butylphenyl)propionic acid methyl ester

3,5-bis(1,1-dimethylethyl)-4-hydroxy-benzenepropanoicacimethylester

METHY(3,5-DI-TERT-BUTYL-4-HYDROXYPHENYL) PROPIONATE

3,5-Di-tert-butyl-4-hydroxybenzenepropionic acid methyl ester

3-[4-Hydroxy-3,5-bis(tert-butyl)phenyl]propanoic acid methyl ester

4-Hydroxy-3,5-bis(tert-butyl)benzenepropanoic acid methyl ester

methyl 3-(3',5'-di-t-butyl-4'-hydroxyphenyl)propionate

Methyl 3-(4-hydroxy-3,5-di-t-butylphenyl) propionate

Methyl 3-(3,5-di-ter

3 - (3, 5-2 tertiary butyl - 4 - hydroxy phenyl) propionic acid Methyl ester

Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate, >=99%

methyl di-tert-butyl hydroxyhydrocinnamate

Metilox

Propofol Related Compound 3

5-di-tert-butyl-4-hydroxyphenyl)propionate

Methyl 3-(3

METHYL DI-t-BUTYL HYDROXYHYDROCINNAMATE

3,5-Bis(1,1-dimethylethyl)-4-hydroxybenzenepropanoic acid me...

3,5-di-tert-butyl-4-hydroxyphenyl

Propofol Impurity 35

Cefditoren Pivoxil Impurity 22 Sodium Salt

Methylβ-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate

6386-38-5

6386-35-5

Carboxylic

Aromatic Esters

Industrial/Fine Chemicals