(2-pyridyldithio)-PEG4-propargyl
- Product Name
- (2-pyridyldithio)-PEG4-propargyl
- CAS No.
- 2170240-99-8
- Chemical Name
- (2-pyridyldithio)-PEG4-propargyl
- Synonyms
- (2-pyridyldithio)-PEG4-propargyl;Pyridine, 2-(3,6,9,12-tetraoxapentadec-14-yn-1-yldithio)-
- CBNumber
- CB34849381
- Molecular Formula
- C16H23NO4S2
- Formula Weight
- 357.49
- MOL File
- 2170240-99-8.mol
(2-pyridyldithio)-PEG4-propargyl Property
- Boiling point:
- 465.6±45.0 °C(Predicted)
- Density
- 1.18±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C, stored under nitrogen
- form
- Liquid
- pka
- 1.81±0.12(Predicted)
- color
- Colorless to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- BP-23858
- Product name
- (2-pyridyldithio)-PEG4-propargyl
- Purity
- 98%
- Packaging
- 100mg
- Price
- $320
- Updated
- 2021/12/16
(2-pyridyldithio)-PEG4-propargyl Chemical Properties,Usage,Production
Description
(2-pyridyldithio)-PEG4-propargyl is a PEG linker which contains a pyridyl disulfide moiety and a propargyl group. The pyridyl disulfide group can react with thiol groups of proteins over a wide range of pH levels. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media.
Uses
(2-Pyridyldithio)-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
(2-pyridyldithio)-PEG4-propargyl Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (2-pyridyldithio)-PEG4-propargyl manufacturers
- Product
- (2-pyridyldithio)-PEG4-propargyl 2170240-99-8
- Price
- US $0.00/mg
- Min. Order
- 50mg
- Purity
- >99.00%
- Supply Ability
- 50mg
- Release date
- 2024-03-21