(2-pyridyldithio)-PEG4-propargyl

Product Name: (2-pyridyldithio)-PEG4-propargyl
CAS No.: 2170240-99-8
Chemical Name: (2-pyridyldithio)-PEG4-propargyl
Synonyms: (2-pyridyldithio)-PEG4-propargyl;Pyridine, 2-(3,6,9,12-tetraoxapentadec-14-yn-1-yldithio)-
CBNumber: CB34849381
Molecular Formula: C16H23NO4S2
Formula Weight: 357.49
MOL File: 2170240-99-8.mol

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(2-pyridyldithio)-PEG4-propargyl Property

Boiling point:: 465.6±45.0 °C(Predicted)
Density: 1.18±0.1 g/cm3(Predicted)
storage temp.: 2-8°C, stored under nitrogen
form: Liquid
pka: 1.81±0.12(Predicted)
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-23858
Product name: (2-pyridyldithio)-PEG4-propargyl
Purity: 98%
Packaging: 100mg
Price: $320
Updated: 2021/12/16

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(2-pyridyldithio)-PEG4-propargyl Chemical Properties,Usage,Production

Description

(2-pyridyldithio)-PEG4-propargyl is a PEG linker which contains a pyridyl disulfide moiety and a propargyl group. The pyridyl disulfide group can react with thiol groups of proteins over a wide range of pH levels. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media.

Uses

(2-Pyridyldithio)-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

(2-pyridyldithio)-PEG4-propargyl Preparation Products And Raw materials

Raw materials

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(2-pyridyldithio)-PEG4-propargyl Suppliers

China 16 United States 5 Global 21

Xi'an Confluore Biological Technology Co., Ltd.

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View Lastest Price from (2-pyridyldithio)-PEG4-propargyl manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: (2-pyridyldithio)-PEG4-propargyl 2170240-99-8
Price: US $0.00/mg
Min. Order: 50mg
Purity: >99.00%
Supply Ability: 50mg
Release date: 2024-03-21

2170240-99-8, (2-pyridyldithio)-PEG4-propargylRelated Search:

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(2-pyridyldithio)-PEG4-propargyl

Pyridine, 2-(3,6,9,12-tetraoxapentadec-14-yn-1-yldithio)-

2170240-99-8