2-Thiopheneglyoxylic acid
- Product Name
- 2-Thiopheneglyoxylic acid
- CAS No.
- 4075-59-6
- Chemical Name
- 2-Thiopheneglyoxylic acid
- Synonyms
- 2-thioylformic acid;RARECHEM AL BO 2203;2-Thiopheneglyoxylic;2-THIENYLGLYOXYLIC ACID;2-Thienylglyoxalic acid;a-Thienylglyoxalic acid;2-THIOPHENEGLYOXYLIC ACID;(2-Thienyl)oxoacetic acid;Oxo(2-thienyl)acetic acid;Thiophen-2-glyoxylic acid
- CBNumber
- CB3485314
- Molecular Formula
- C6H4O3S
- Formula Weight
- 156.16
- MOL File
- 4075-59-6.mol
2-Thiopheneglyoxylic acid Property
- Melting point:
- 88-91 °C (lit.)
- Boiling point:
- 250.38°C (rough estimate)
- Density
- 1.404 (estimate)
- refractive index
- 1.5151 (estimate)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- solid
- pka
- 2.09±0.54(Predicted)
- Sensitive
- Hygroscopic
- BRN
- 115791
- CAS DataBase Reference
- 4075-59-6(CAS DataBase Reference)
Safety
- Hazard Codes
- C,Xi
- Risk Statements
- 34
- Safety Statements
- 26-27-28-36/37/39-45
- RIDADR
- UN 3261 8/PG 2
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
N-Bromosuccinimide Price
- Product number
- 222275
- Product name
- 2-Thiopheneglyoxylic acid
- Purity
- 95%
- Packaging
- 1g
- Price
- $96.6
- Updated
- 2025/07/31
- Product number
- T344805
- Product name
- α-oxo-2-ThiopheneaceticAcid
- Packaging
- 10g
- Price
- $470
- Updated
- 2021/12/16
- Product number
- C254
- Product name
- 2-Thiopheneglyoxylic acid
- Packaging
- 4x25g
- Price
- $494
- Updated
- 2021/12/16
- Product number
- CHM0021685
- Product name
- 2-OXO-2-(2-THIENYL)ACETIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $606.38
- Updated
- 2021/12/16
- Product number
- 72643
- Product name
- α-oxo-2-ThiopheneaceticAcid
- Packaging
- 2.5g
- Price
- $650
- Updated
- 2021/12/16
2-Thiopheneglyoxylic acid Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
2-Thiopheneglyoxylic acid was used in the synthesis of europium complexes.
Synthesis
4075-58-5
4075-59-6
The general procedure for the synthesis of 2-thiophene glyoxalate from ethyl thiophene-2-glyoxalate was as follows: to a solution of ethyl thiophene-2-glyoxalate (4 mL, 27.17 mmol) in ethanol (60 mL) was added an aqueous 4N sodium hydroxide solution (10.2 mL, 40.76 mmol). The reaction mixture was stirred at room temperature for 18 hours. Upon completion of the reaction, the reaction solution was acidified with 2N aqueous hydrochloric acid to pH 2. Subsequently, the solvent was removed by vacuum distillation to afford 2-thiophene glyoxalic acid as a yellow solid product (quantitative yield). The resulting residue was used directly in the subsequent reaction without further purification.LCMS analysis (Method 2): [MH-] = 155 with a retention time of 0.71 min.
References
[1] Patent: WO2016/193244, 2016, A1. Location in patent: Page/Page column 80
[2] Chemical Communications, 2014, vol. 50, # 34, p. 4489 - 4491
[3] Patent: WO2016/177849, 2016, A1. Location in patent: Page/Page column 60
[4] Advanced Synthesis and Catalysis, 2018, vol. 360, # 21, p. 4184 - 4190
2-Thiopheneglyoxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Thiopheneglyoxylic acid manufacturers
- Product
- 2-Thiopheneglyoxylic acid 4075-59-6
- Price
- US $0.10-0.10/KG
- Min. Order
- 10KG
- Purity
- 99%+
- Supply Ability
- 10000KG
- Release date
- 2024-04-24
- Product
- 2-Thiopheneglyoxylic acid 4075-59-6
- Price
- US $8.00/KG
- Min. Order
- 1KG
- Purity
- ＞98% HPLC
- Supply Ability
- 20 tons
- Release date
- 2020-02-17