ChemicalBook > CAS DataBase List > SCOPARONE

SCOPARONE

Product Name
SCOPARONE
CAS No.
120-08-1
Chemical Name
SCOPARONE
Synonyms
scoparon;SCOPARONE;escoparone;AKOS 236-43;Scoparone-RM;SCOPARONE(RG);DIMETHYLESCULETIN;DIMETHOXYCOUMARIN;Scoparone 120-08-1;SCOPARONE(RG) 10mg
CBNumber
CB3486326
Molecular Formula
C11H10O4
Formula Weight
206.19
MOL File
120-08-1.mol
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SCOPARONE Property

Melting point:
143-145 °C (lit.)
Boiling point:
265.04°C (rough estimate)
Density 
1.0858 (rough estimate)
refractive index 
1.4389 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
>8.4mg/mL in DMSO
form 
Powder
color 
Light yellow to yellow
Merck 
13,8479
LogP
1.331 (est)
CAS DataBase Reference
120-08-1(CAS DataBase Reference)
NIST Chemistry Reference
2H-1-benzopyran-2-one, 6,7-dimethoxy-(120-08-1)
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Safety

Hazard Codes 
Xn
Risk Statements 
23/24/25-36-22
Safety Statements 
27/28-36/37/39-45-26
RIDADR 
2811
WGK Germany 
3
RTECS 
GN6550000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29322090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
254886
Product name
6,7-Dimethoxycoumarin
Purity
98%
Packaging
250mg
Price
$170
Updated
2024/03/01
Sigma-Aldrich
Product number
254886
Product name
6,7-Dimethoxycoumarin
Purity
98%
Packaging
1g
Price
$377
Updated
2024/03/01
Cayman Chemical
Product number
20046
Product name
Scoparone
Purity
≥98%
Packaging
10mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
20046
Product name
Scoparone
Purity
≥98%
Packaging
25mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
20046
Product name
Scoparone
Purity
≥98%
Packaging
50mg
Price
$214
Updated
2024/03/01
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SCOPARONE Chemical Properties,Usage,Production

Uses

Scoparone-13C2D6 is a by-product in the synthesis of Scopoletin-13C,d3 (S200502). Scopoletin-13C,d3, is the labeled analogue of Scopoletin (S200500), used for cosmetics, topical formulations, and foods. Scoparone-13C2D6 is also the labeled form of Scoparone (S199980), which regulates the expression of Th1/Th2 cytokines and IgE and is effective in treating allergic rhinitis.

Definition

ChEBI: Scoparone is a member of the class of coumarins that is esculetin in which the two hydroxy groups at positions 6 and 7 are replaced by methoxy groups. It is a major constituent of the Chinese herbal medicine Yin Chen Hao, and exhibits a variety of pharmacological activities such as anti-inflammatory, anti-allergic, and anti-tumor activities. It has a role as a plant metabolite, an anti-inflammatory agent, an antilipemic drug, an immunosuppressive agent, an antihypertensive agent and an anti-allergic agent. It is a member of coumarins and an aromatic ether. It is functionally related to an esculetin.

Synthesis Reference(s)

Synthesis, p. 1026, 1986 DOI: 10.1055/s-1986-31859

General Description

6,7-Dimethoxycoumarin inhibits the in vitro growth of Phytophthora citrophthora, Verticillium dahliae, Penicillium digitatum, P. italicum, Colletotrichum gloeosporioides, Diplodia natalensis and Hendersonula toruloidea. Determination and pharmacokinetic study of 6,7-dimethoxycoumarin in rat plasma after intragastric administration of different decoctions of Yinchenhao Tang by reversed-phase HPLC method with UV detection has been reported.

Safety Profile

Poison by ingestion and intraperitoneal routes. Experimental reproductive effects. An anthypertensive agent. When heated to decomposition it emits acrid smoke and irritating fumes.

SCOPARONE Preparation Products And Raw materials

Raw materials

Esculetin Dimethyl sulfate

Preparation Products

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View Lastest Price from SCOPARONE manufacturers

Shanghai Standard Technology Co., Ltd.
Product
6,7-Dimethoxycoumarin 120-08-1
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-09-27
Shanghai Standard Technology Co., Ltd.
Product
6,7-Dimethoxycoumarin 120-08-1
Price
US $0.00/mg
Min. Order
5mg
Purity
Analytical Standard
Supply Ability
10 g
Release date
2019-09-27
NanJing Spring & Autumn Biological Engineering CO., LTD.
Product
Scoparone 120-08-1 120-08-1
Price
US $10.50/mg
Min. Order
20mg
Purity
≥98%
Supply Ability
1000.00 KGS
Release date
2019-07-10

120-08-1, SCOPARONERelated Search:

6,7-Diethoxy-4-(trifluoromethyl)coumarin 6,7-DIMETHOXY-4-METHYLCOUMARIN 6,7,8-TRIMETHOXYCOUMARIN ESCULETIN DIBENZYL ETHER Oxamarin 8-ACETYL DIMETHOXYCOUMARIN SCOPARONE 4-BROMOMETHYL-6,7-DIMETHOXYCOUMARIN FRAXIDIN 5,7-Dimethoxycoumarin Dimethyl ether Coumarin Esculetin 6,7-DIMETHOXY-4-ETHYLCOUMARIN 6,7-DIACETOXY-4-METHYLCOUMARIN scopolin 6,7-DIMETHOXY-4-(TRIFLUOROMETHYL)COUMARIN 6,7-DIMETHOXYCOUMARIN-4-ACETIC ACID

  • Scoparone 120-08-1
  • 6,7-dihydroxy-3,4-dimethyl-1-benzopyran-2-one
  • 6,7-dimethoxy-coumari
  • 6,7-Dimethoxycoumarine
  • aesculetindimethylether
  • escoparone
  • scoparon
  • 6,7-DIMETHOXY-CHROMEN-2-ONE
  • 6,7-DIMETHOXYCOUMARIN
  • 6,7-DIMETHYLESCULETIN
  • AKOS 236-43
  • ESCULETIN DIMETHYL ETHER
  • DIMETHYLESCULETIN
  • SCOPARONE
  • 6,7-Dimethoxycoumarin, 98%, from Ligusticum chuanxiong Hort.
  • 6,7-Dimethoxy-2H-1-benzopyran-2-one
  • 6,7-dimethoxy-benzopyran-2-on
  • 6,7-dimethoxybenzopyran-2-one
  • 6,7-dimethoxy-2-benzopyrone
  • SCOPARONE, 98% BY HPLC
  • SCOPARONE(RG)
  • DIMETHOXYCOUMARIN
  • 6,7-DIMETHYLESCULETIN WITH HPLC
  • 2H-1-Benzopyran-2-one, 6,7-dimethoxy-
  • Scoparone，6,7-dimethoxycoumarin，6,7-dimethylesculetin
  • 6,7-Dimethoxy-2H-chromen-2-one
  • Scopoletin Methyl ether
  • Scoparone,escoparone6,7-diMethoxycouMarin
  • 6,7-Dimethoxycoumarin,Scoparone
  • 6,7-Dimethoxycoumarin 6,7-Dimethoxy-2H-chromen-2-one
  • SCOPARONE ISO 9001：2015 REACH
  • 6,7-Dimethylesculetin (Scoparone)
  • TIANFU CHEM-- SCOPARONE
  • scoparone,escoparone6
  • SCOPARONE(RG) 10mg
  • Scoparone-RM
  • 120-08-1
  • 128-08-1
  • C11H10O4
  • Fluorescent Probes, Labels, Particles and Stains
  • Fluorescent Labels
  • Other Fluorescent Labels
  • Biochemicals and Reagents
  • BioChemical
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Inhibitors
  • Coumarins
  • API intermediates