Emodin-3-methyl ether

Product Name: Emodin-3-methyl ether
CAS No.: 521-61-9
Chemical Name: Emodin-3-methyl ether
Synonyms: PHYSCION;parietin;PHYSCIONE;RHEOCHRYSIDIN;MethyleModin;Rheochrysidin (Physcion);Emodin-3-methyl ether 521-61-9;Physcion-RM;Physcic acid;PHYSCION(SH)
CBNumber: CB3487525
Molecular Formula: C16H12O5
Formula Weight: 284.26
MOL File: 521-61-9.mol

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Emodin-3-methyl ether Property

Melting point:: 196-206°C
Boiling point:: 560.5±50.0 °C(Predicted)
Density: 1.448±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer, Under Inert Atmosphere
solubility: Chloroform (Slightly, Heated), Ethyl Acetate (Slightly, Heated), Methanol (Slightly)
form: Solid
pka: 6.23±0.20(Predicted)
color: Yellow to Dark Yellow to Dark Orange
BRN: 6770499
Stability:: Hygroscopic
InChI: InChI=1S/C16H12O5/c1-7-3-9-13(11(17)4-7)16(20)14-10(15(9)19)5-8(21-2)6-12(14)18/h3-6,17-18H,1-2H3
InChIKey: FFWOKTFYGVYKIR-UHFFFAOYSA-N
SMILES: C1(O)=C2C(C(=O)C3=C(C2=O)C(O)=CC(C)=C3)=CC(OC)=C1
LogP: 5.078 (est)
CAS DataBase Reference: 521-61-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
RTECS: CB6720000
F: 10
HS Code: 29146990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 93893
Product name: Physcion
Purity: analytical standard
Packaging: 10mg
Price: $430
Updated: 2025/07/31

Sigma-Aldrich

Product number: 17797
Product name: Physcion
Purity: ≥98.0% (TLC)
Packaging: 100mg
Price: $682
Updated: 2025/07/31

TCI Chemical

Product number: P2931
Product name: Physcion
Packaging: 100MG
Price: $236
Updated: 2025/07/31

Cayman Chemical

Product number: 19863
Product name: Physcion
Purity: ≥98%
Packaging: 5mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19863
Product name: Physcion
Purity: ≥98%
Packaging: 10mg
Price: $57
Updated: 2024/03/01

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Emodin-3-methyl ether Chemical Properties,Usage,Production

Chemical Properties

Yellow Solid

Uses

antibacterial, cathartic

Uses

A natural anthraquinone derivative, on the infection process of Blumeria graminis on wheat. Physcion is one of the important active ingredients of ethanol extract from the roots of Chinese rhubarb (Rheum officinale) for controlling powdery mildew.

Definition

ChEBI: A dihydroxyanthraquinone that is 9,10-anthraquinone bearing hydroxy substituents at positions 1 and 8, a methoxy group at position 3, and a methyl group at position 6.

Biological Activity

Anthraquinone-derivative found in medicinal herbs.

in vivo

Physcion (20 or 40 mg/kg, p.o., once daily for 7 days) exerts neuroprotective effects by inhibiting the TLR4/NF-κB signaling pathway in an ischemia-reperfusion-induced SD rat model^[3]. Physcion (4 or 9 mg/kg, p.o., once daily for 6 days) effectively alleviates infection symptoms caused by Chlamydia psittaci 6 BCE in SPF chickens^[4].

Animal Model:	Ischemia-reperfusion (I/R)-induced focal cerebral ischemia model in SD rats^[3]
Dosage:	20 or 40 mg/kg
Administration:	Oral gavage (p.o.), once daily for 7 days
Result:	Significantly reduced the brain water content and the NSS (Neurological Severity Score) in I/R rats, compared to I/R group. Obviously decreased areas of infarction compared to I/R group.

Animal Model:	SPF chickens (21 days old) infected intra-laryngeally with Chlamydia psittaci 6 BCE^[4]
Dosage:	4 or 9 mg/kg
Administration:	Oral gavage (p.o.), once daily for 6 days
Result:	Dose-dependently alleviated respiratory distress, air sac and lung lesions, and bacterial load in the spleen in infected chickens.

IC 50

TLR4

Emodin-3-methyl ether Preparation Products And Raw materials

Raw materials

Preparation Products

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Emodin-3-methyl ether Suppliers

Canada 1 China 361 France 2 Germany 4 Switzerland 1 United Kingdom 8 United States 30 USA 1 Global 408

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View Lastest Price from Emodin-3-methyl ether manufacturers

Shaanxi Xianhe Biotech Co., Ltd

Product: Physcion 521-61-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 0.99
Supply Ability: 1000KG
Release date: 2025-04-24

Shanghai Standard Technology Co., Ltd.

Product: Physcion 521-61-9
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-10-08

Shanghai Standard Technology Co., Ltd.

Product: Physcion 521-61-9
Price: US $0.00/mg
Min. Order: 5mg
Purity: Analytical Standard
Supply Ability: 10 g
Release date: 2019-10-08

521-61-9, Emodin-3-methyl etherRelated Search:

Emodin-8-glucoside Hypericin Resveratrol Baicalin FORSYTHOSIDE A (+)-FANGCHINOLINE Osthole Aloe emodin Physcion 8-β-D-glucoside Physcion 8-o-beta-D-monoglucoside Emodin 8-glucoside Emodin Anthraquinone Emodin-3-methyl ether Steffimycin FRANGULIN B FRANGULIN A FRANGULIN A

3-methoxy-6-methyl-

1,8-Dihydroxy-3-methoxy-6-methyl-9,10-anthraquinone

EMODIN-3-METHYLETHER(RG)(CALL)

1,8-Dihydroxy-3-Methoxy-6-Methyl-

Rheochrysidin (Physcione)

MethyleModin

Physcic acid

Przewalskinone B

1,8-dihydroxy-3-Methoxy-6-Methylanthracene-9,10-dione

Physcion, froM RheuM palMatuM

Physcion, >=98%

Physcion, Emodin-3-methyl ether

1,8-DIHYDROXY-3-METHOXY-6-METHYLANTHRAQUINONE

EMODIN 3-METHYL ETHER

RHEOCHRYSIDIN

PHYSCION WITH HPLC

Physcion, 98%, from Rheum palmatum

Emodin-3-methyl ether 521-61-9

PHYSCION

PHYSCIONE

1,8-dihydroxy-3-methoxy-6-methyl-10-anthracenedione

1,8-dihydroxy-3-methoxy-6-methyl-9,10-anthracenedione

1,8-dihydroxy-3-methoxy-6-methyl-anthraquinon

1,8-dihydroxy-3-methyl-6-methoxy-9,10-anthraquinone

parietin

1,8-dihydroxy-3-methoxy-6-methylanthraquinone emodin 3-methyl ether

Physcion Physcion

PHYSCION(SH)

ANTHRAQUINONE,1,8-DIHYDROXY-3-METHOXY-6-METHYL-

EMODIN 3-METHYL ETHER hplc

Rheochrysidin (Physcion)

9,10-Anthracenedione, 1,8-dihydroxy-3-methoxy-6-methyl-

Rhubarb extract/Emodin-3-methyl ether

Rheochrysidin (Parietin

5'-Tetramethylbenzidine dihydrochloride

Emodin methyl ether

Physcione|||Parietin|||Rheochrysidin

Physcion-RM

Emodinum methylicum

521-61-9

521-61-0

Agro-Products

Aromatics

Inhibitors

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

The group of Polydatin

Anthraquinones, Hydroquinones and Quinones