ChemicalBook > CAS DataBase List > 1,4-Dioxaspiro[4.5]decan-8-one

1,4-Dioxaspiro[4.5]decan-8-one

Product Name
1,4-Dioxaspiro[4.5]decan-8-one
CAS No.
4746-97-8
Chemical Name
1,4-Dioxaspiro[4.5]decan-8-one
Synonyms
1,4-CYCLOHEXANEDIONE MONOETHYLENE ACETAL;1,4-CYCLOHEXANEDIONE MONOETHYLENE KETAL;cyclohexanedione monoethylene ketal;1,4-Cyclohexanedione ethylene ketal;KEHK;4-Cyclohexanedione Mo;cyclohexanedione monoacetal;4-Dioxaspiro[4.5]decan-8-one;1,4-Dioxiro[4.5]decan-8-one.;1,4-Cyclohexanedion Monoethyl
CBNumber
CB3496677
Molecular Formula
C8H12O3
Formula Weight
156.18
MOL File
4746-97-8.mol
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1,4-Dioxaspiro[4.5]decan-8-one Property

Melting point:
70-73 °C (lit.)
Boiling point:
112C
Density 
1.0887 (rough estimate)
refractive index 
1.4430 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Soluble in chloroform & methanol.
form 
Crystalline Powder or Crystals
color 
White to beige
Sensitive 
Moisture Sensitive
BRN 
117631
InChI
InChI=1S/C8H12O3/c9-7-1-3-8(4-2-7)10-5-6-11-8/h1-6H2
InChIKey
VKRKCBWIVLSRBJ-UHFFFAOYSA-N
SMILES
O1C2(CCC(=O)CC2)OCC1
CAS DataBase Reference
4746-97-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-36/37/39-26
WGK Germany 
3
F 
8-10-21
Hazard Note 
Irritant
HS Code 
29110000
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
274879
Product name
1,4-Cyclohexanedione monoethylene acetal
Purity
97%
Packaging
5g
Price
$43.3
Updated
2025/07/31
Sigma-Aldrich
Product number
274879
Product name
1,4-Cyclohexanedione monoethylene acetal
Purity
97%
Packaging
25g
Price
$80
Updated
2025/07/31
TCI Chemical
Product number
C1292
Product name
1,4-Cyclohexanedione Monoethyleneketal
Purity
>98.0%(GC)
Packaging
5g
Price
$17
Updated
2025/07/31
TCI Chemical
Product number
C1292
Product name
1,4-Cyclohexanedione Monoethyleneketal
Purity
>98.0%(GC)
Packaging
25g
Price
$42
Updated
2025/07/31
Sigma-Aldrich
Product number
274879
Product name
1,4-Cyclohexanedione monoethylene acetal
Purity
97%
Packaging
100g
Price
$200
Updated
2025/07/31
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1,4-Dioxaspiro[4.5]decan-8-one Chemical Properties,Usage,Production

Chemical Properties

1,4-Dioxaspiro[4.5]decan-8-one is white to beige crystalline powder or crystals

Uses

1,4-Dioxaspiro[4.5]decan-8-one is used in the preparation of series of potent analgesic compounds. 1,4-Cyclohexanedione Monoethylene Acetal is also used as a building block in the synthesis of tritium labelled probes for the autoradiography study of the dopamine reuptake complex.

Uses

Intermediates of Liquid Crystals

Uses

1,4-Cyclohexanedione is used in the preparation of series of potent analgesic compounds. 1,4-Cyclohexanedione is also used as a building block in the synthesis of tritium labelled probes for the autoradiography study of the dopamine reuptake complex.

Application

1,4-Dioxaspiro[4.5]decan-8-one can be used:
(1) Used in a study of microwave-assisted reductive amination.
(2) Via a novel aromatization process, this bicyclic frame can be converted into a series of 5-alkoxytryptamine derivatives including serotonin, melatonin and bufotenin.

Synthesis

In a dry Schlenk tube, [Rh(cod)Cl]2 (9.9 mg, 20.0 ??mol), (R)-Binap (27.4 mg, 44.0 ??mol), and Durum (20.0 mg, internal standard) were dissolved in CH2Cl2 (8.0 mL); then, 2 mmol of the substrate was added to the solution at room temperature under nitrogen. After stirring for 1 min, CF3CO2Ag (8.8 mg, 40.0 ??mol) was added to the mixture. The solution was stirred at 25??C under nitrogen and monitored by GC or HPLC to determine the conversion and ee values. After evaporation of the solvent, the residue was purified by chromatography using EtOAc/hexane (20/80) as eluent to give the product 1,4-cyclohexanedione monoethylene glycol ketal.

Purification Methods

Recrystallise it from pet ether. It sublimes slowly on attempted distillation. Also purify it by dissolving it in Et2O and adding pet ether (b 60-80o) until turbid and cooling. [Gardner et al. J Am Chem Soc 22 1206 1957, Britten & Lockwood J Chem Soc Perkin Trans 1 1824 1974.] [Beilstein 19/4 V 93.]

1,4-Dioxaspiro[4.5]decan-8-one Preparation Products And Raw materials

Raw materials

Preparation Products

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1,4-Dioxaspiro[4.5]decan-8-one Suppliers

Americas 1 Belgium 6 Canada 2 China 467 Europe 4 France 1 Germany 9 India 30 Japan 11 South Korea 1 Switzerland 2 The Netherlands 1 Ukraine 2 United Kingdom 15 United States 53 Global 605
Xi 'an billiton biological technology co., LTD
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18191268030
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wang.yali@xatuochao.com
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China
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Hebei Maison Chemical Co.,Ltd.
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155-11852758 15511852758
Fax
0311-83832777
Email
ruby@maisonchem.com.cn
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China
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Beijing Ouhe Technology Co., Ltd
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010-010-82967028 13522913783
Fax
+86-10-82967029
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2355560935@qq.com
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China
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
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025-66113011 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
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China
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XIANAONARUNNEWMATERIALCo.,Ltd
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029-81509060 13629280593
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China
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Xi'an Qingxiang Biotechnology Co., Ltd
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029-18192656670 18192656670
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2557411153@qq.com
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China
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J & K SCIENTIFIC LTD.
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18210857532; 18210857532
Fax
86-10-82849933
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jkinfo@jkchemical.com
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China
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96815
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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4006356688 18621169109
Fax
86-21-61259102
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market03@meryer.com
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China
ProdList
40228
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INTATRADE GmbH
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+49 3493/605464
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+49 3493/605470
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sales@intatrade.de
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Germany
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future industrial shanghai co., ltd
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400-0066400 13621662912
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021-55660885
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sales@jonln.com
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China
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View Lastest Price from 1,4-Dioxaspiro[4.5]decan-8-one manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
1,4-Dioxaspiro[4.5]decan-8-one 4746-97-8
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-18
Hebei Chuanghai Biotechnology Co., Ltd
Product
1,4-Dioxaspiro[4.5]decan-8-one 4746-97-8
Price
US $10.00/KG
Min. Order
100KG
Purity
99%
Supply Ability
100 mt
Release date
2024-12-02
Speranza Chemical Co., Ltd.
Product
1,4-Cyclohexanedione monoethyleneacetal 4746-97-8
Price
US $20.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
300 Tons/ year
Release date
2019-12-25

4746-97-8, 1,4-Dioxaspiro[4.5]decan-8-oneRelated Search:

Diethylene glycol DIOXOPROMETHAZINE HCL 2-Bromomethyl-1,3-dioxolane Decane Buspirone Cyclohexanone Selenium dioxide 1,4-Dioxane 1,4-Cyclohexanedione 2,2-DIMETHYL-1,3-DIOXOLANE 4-HYDROXYCYCLOHEXANONE 1,1-DIMETHOXYCYCLOHEXANE 2-METHYL-1,3-DIOXOLANE DIOXOPROMETHAZINE HEXANAL DIMETHYL ACETAL 1,3-Dioxolane 2-ETHYL-2-METHYL-1,3-DIOXOLANE 3,3-DIMETHOXYHEXANE

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