1,4-Dioxaspiro[4.5]decan-8-one
- Product Name
- 1,4-Dioxaspiro[4.5]decan-8-one
- CAS No.
- 4746-97-8
- Chemical Name
- 1,4-Dioxaspiro[4.5]decan-8-one
- Synonyms
- 1,4-CYCLOHEXANEDIONE MONOETHYLENE ACETAL;1,4-CYCLOHEXANEDIONE MONOETHYLENE KETAL;cyclohexanedione monoethylene ketal;1,4-Cyclohexanedione ethylene ketal;KEHK;4-Cyclohexanedione Mo;cyclohexanedione monoacetal;4-Dioxaspiro[4.5]decan-8-one;1,4-Dioxiro[4.5]decan-8-one.;1,4-Cyclohexanedion Monoethyl
- CBNumber
- CB3496677
- Molecular Formula
- C8H12O3
- Formula Weight
- 156.18
- MOL File
- 4746-97-8.mol
1,4-Dioxaspiro[4.5]decan-8-one Property
- Melting point:
- 70-73 °C (lit.)
- Boiling point:
- 112C
- Density
- 1.0887 (rough estimate)
- refractive index
- 1.4430 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Soluble in chloroform & methanol.
- form
- Crystalline Powder or Crystals
- color
- White to beige
- Sensitive
- Moisture Sensitive
- BRN
- 117631
- InChI
- InChI=1S/C8H12O3/c9-7-1-3-8(4-2-7)10-5-6-11-8/h1-6H2
- InChIKey
- VKRKCBWIVLSRBJ-UHFFFAOYSA-N
- SMILES
- O1C2(CCC(=O)CC2)OCC1
- CAS DataBase Reference
- 4746-97-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 22-24/25-36/37/39-26
- WGK Germany
- 3
- F
- 8-10-21
- Hazard Note
- Irritant
- HS Code
- 29110000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 274879
- Product name
- 1,4-Cyclohexanedione monoethylene acetal
- Purity
- 97%
- Packaging
- 5g
- Price
- $42
- Updated
- 2024/03/01
- Product number
- 274879
- Product name
- 1,4-Cyclohexanedione monoethylene acetal
- Purity
- 97%
- Packaging
- 25g
- Price
- $77.6
- Updated
- 2024/03/01
- Product number
- C1292
- Product name
- 1,4-Cyclohexanedione Monoethyleneketal
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $17
- Updated
- 2024/03/01
- Product number
- C1292
- Product name
- 1,4-Cyclohexanedione Monoethyleneketal
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $42
- Updated
- 2024/03/01
- Product number
- A10408
- Product name
- 1,4-Cyclohexanedione monoethylene acetal, 97%
- Packaging
- 5g
- Price
- $40.65
- Updated
- 2024/03/01
1,4-Dioxaspiro[4.5]decan-8-one Chemical Properties,Usage,Production
Chemical Properties
1,4-Dioxaspiro[4.5]decan-8-one is white to beige crystalline powder or crystals
Uses
1,4-Dioxaspiro[4.5]decan-8-one is used in the preparation of series of potent analgesic compounds. 1,4-Cyclohexanedione Monoethylene Acetal is also used as a building block in the synthesis of tritium labelled probes for the autoradiography study of the dopamine reuptake complex.
Uses
Intermediates of Liquid Crystals
Uses
1,4-Cyclohexanedione is used in the preparation of series of potent analgesic compounds. 1,4-Cyclohexanedione is also used as a building block in the synthesis of tritium labelled probes for the autoradiography study of the dopamine reuptake complex.
Application
1,4-Dioxaspiro[4.5]decan-8-one can be used:
(1) Used in a study of microwave-assisted reductive amination.
(2) Via a novel aromatization process, this bicyclic frame can be converted into a series of 5-alkoxytryptamine derivatives including serotonin, melatonin and bufotenin.
Purification Methods
Recrystallise it from pet ether. It sublimes slowly on attempted distillation. Also purify it by dissolving it in Et2O and adding pet ether (b 60-80o) until turbid and cooling. [Gardner et al. J Am Chem Soc 22 1206 1957, Britten & Lockwood J Chem Soc Perkin Trans 1 1824 1974.] [Beilstein 19/4 V 93.]
1,4-Dioxaspiro[4.5]decan-8-one Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,4-Dioxaspiro[4.5]decan-8-one manufacturers
- Product
- 1,4-Dioxaspiro[4.5]decan-8-one 4746-97-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-01-18
- Product
- 1,4-Cyclohexanedione monoethyleneacetal 4746-97-8
- Price
- US $20.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 300 Tons/ year
- Release date
- 2019-12-25
- Product
- 1,4-Dioxaspiro[4.5]decan-8-one 4746-97-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99.5%
- Supply Ability
- 1T
- Release date
- 2023-02-08