1,4-Dioxaspiro[4.5]decan-8-one

Product Name: 1,4-Dioxaspiro[4.5]decan-8-one
CAS No.: 4746-97-8
Chemical Name: 1,4-Dioxaspiro[4.5]decan-8-one
Synonyms: 1,4-CYCLOHEXANEDIONE MONOETHYLENE ACETAL;1,4-CYCLOHEXANEDIONE MONOETHYLENE KETAL;cyclohexanedione monoethylene ketal;1,4-Cyclohexanedione ethylene ketal;KEHK;4-Cyclohexanedione Mo;cyclohexanedione monoacetal;4-Dioxaspiro[4.5]decan-8-one;1,4-Dioxiro[4.5]decan-8-one.;1,4-Cyclohexanedion Monoethyl
CBNumber: CB3496677
Molecular Formula: C8H12O3
Formula Weight: 156.18
MOL File: 4746-97-8.mol

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1,4-Dioxaspiro[4.5]decan-8-one Property

Melting point:: 70-73 °C (lit.)
Boiling point:: 112C
Density: 1.0887 (rough estimate)
refractive index: 1.4430 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Soluble in chloroform & methanol.
form: Crystalline Powder or Crystals
color: White to beige
Sensitive: Moisture Sensitive
BRN: 117631
InChI: InChI=1S/C8H12O3/c9-7-1-3-8(4-2-7)10-5-6-11-8/h1-6H2
InChIKey: VKRKCBWIVLSRBJ-UHFFFAOYSA-N
SMILES: O1C2(CCC(=O)CC2)OCC1
CAS DataBase Reference: 4746-97-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25-36/37/39-26
WGK Germany: 3
F: 8-10-21
Hazard Note: Irritant
HS Code: 29110000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 274879
Product name: 1,4-Cyclohexanedione monoethylene acetal
Purity: 97%
Packaging: 5g
Price: $42
Updated: 2024/03/01

Sigma-Aldrich

Product number: 274879
Product name: 1,4-Cyclohexanedione monoethylene acetal
Purity: 97%
Packaging: 25g
Price: $77.6
Updated: 2024/03/01

TCI Chemical

Product number: C1292
Product name: 1,4-Cyclohexanedione Monoethyleneketal
Purity: >98.0%(GC)
Packaging: 5g
Price: $17
Updated: 2024/03/01

TCI Chemical

Product number: C1292
Product name: 1,4-Cyclohexanedione Monoethyleneketal
Purity: >98.0%(GC)
Packaging: 25g
Price: $42
Updated: 2024/03/01

Alfa Aesar

Product number: A10408
Product name: 1,4-Cyclohexanedione monoethylene acetal, 97%
Packaging: 5g
Price: $40.65
Updated: 2024/03/01

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1,4-Dioxaspiro[4.5]decan-8-one Chemical Properties,Usage,Production

Chemical Properties

1,4-Dioxaspiro[4.5]decan-8-one is white to beige crystalline powder or crystals

Uses

1,4-Dioxaspiro[4.5]decan-8-one is used in the preparation of series of potent analgesic compounds. 1,4-Cyclohexanedione Monoethylene Acetal is also used as a building block in the synthesis of tritium labelled probes for the autoradiography study of the dopamine reuptake complex.

Uses

Intermediates of Liquid Crystals

Uses

1,4-Cyclohexanedione is used in the preparation of series of potent analgesic compounds. 1,4-Cyclohexanedione is also used as a building block in the synthesis of tritium labelled probes for the autoradiography study of the dopamine reuptake complex.

Application

1,4-Dioxaspiro[4.5]decan-8-one can be used:
(1) Used in a study of microwave-assisted reductive amination.
(2) Via a novel aromatization process, this bicyclic frame can be converted into a series of 5-alkoxytryptamine derivatives including serotonin, melatonin and bufotenin.

Purification Methods

Recrystallise it from pet ether. It sublimes slowly on attempted distillation. Also purify it by dissolving it in Et2O and adding pet ether (b 60-80o) until turbid and cooling. [Gardner et al. J Am Chem Soc 22 1206 1957, Britten & Lockwood J Chem Soc Perkin Trans 1 1824 1974.] [Beilstein 19/4 V 93.]

1,4-Dioxaspiro[4.5]decan-8-one Preparation Products And Raw materials

Raw materials

Preparation Products

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1,4-Dioxaspiro[4.5]decan-8-one Suppliers

Americas 1 Belgium 6 Canada 2 China 422 Europe 4 France 1 Germany 9 India 32 Japan 11 South Korea 1 Switzerland 2 The Netherlands 1 Ukraine 2 United Kingdom 15 United States 53 Global 562

Hebei Maison Chemical Co.,Ltd.

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Beijing Ouhe Technology Co., Ltd

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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

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BTC Pharmaceutical CO. Ltd

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Nanjing Jubai Biomedical Technology Co., Ltd.

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J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
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View Lastest Price from 1,4-Dioxaspiro[4.5]decan-8-one manufacturers

Speranza Chemical Co., Ltd.

Product: 1,4-Cyclohexanedione monoethyleneacetal 4746-97-8
Price: US $20.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 300 Tons/ year
Release date: 2019-12-25

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: 1,4-Dioxaspiro[4.5]decan-8-one 4746-97-8
Price: US $30.00/kg
Min. Order: 1kg
Purity: 99.7%
Supply Ability: 200000kg
Release date: 2024-04-22

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: cyclohexanedione monoacetal 4746-97-8
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99.7%
Supply Ability: 200000kg
Release date: 2024-04-22

4746-97-8, 1,4-Dioxaspiro[4.5]decan-8-oneRelated Search:

Diethylene glycol DIOXOPROMETHAZINE HCL 2-Bromomethyl-1,3-dioxolane Decane Cyclohexanone 1,4-Cyclohexanedione Buspirone Selenium dioxide 1,4-Dioxane 2,2-DIMETHYL-1,3-DIOXOLANE 4-HYDROXYCYCLOHEXANONE 1,1-DIMETHOXYCYCLOHEXANE 2-METHYL-1,3-DIOXOLANE DIOXOPROMETHAZINE HEXANAL DIMETHYL ACETAL 1,3-Dioxolane 2-ETHYL-2-METHYL-1,3-DIOXOLANE 3,3-DIMETHOXYHEXANE

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Cyclohexane-1,4-dione monoethylene acetal

KEHK

1,4-Dioxaspiro[4.5]decan-8-one ,99%

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1,4-cyclohexanedione monoethylene ketal 4746-97-8

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1,4-Dioxaspiro[4.5]decan-8-one(4746-97-8)

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1,4-Dioxaspiro[4.5]decan-8-one (6CI, 7CI, 8CI, 9CI, ACI)

1,4-CYCLOHEXANEDIONE MONOETHYLENE KETAL > 97% puriss for synthesis

1,4-Cyclohexanedione monoethylene

cyclohexanedione monoacetal

4746-97-8

4740-97-8

C8H12O3

Acetals/Ketals/Ortho Esters

Organic Building Blocks

Oxygen Compounds