5,7-Dihydroxy-4-phenylcoumarin

Product Name: 5,7-Dihydroxy-4-phenylcoumarin
CAS No.: 7758-73-8
Chemical Name: 5,7-Dihydroxy-4-phenylcoumarin
Synonyms: Serratin;LC3-mHTT-IN-AN2, 10 mM in DMSO;5,7-DIHYDROXY-4-PHENYLCOUMARIN;5,7-dihydroxy-4-phenyl-2-chromenone;5,7-dihydroxy-4-phenylchromen-2-one;5,7-Dihydroxy-4-phenyl-chromen-2-one;5,7-Dihydroxy-4-phenyl-2H-chromen-2-one;5,7-dihydroxy-4-phenyl-1-benzopyran-2-one;5,7-Dihydroxy-4-phenyl-2H-1-benzopyran-2-one;2H-1-Benzopyran-2-one, 5,7-dihydroxy-4-phenyl-
CBNumber: CB3505122
Molecular Formula: C15H10O4
Formula Weight: 254.24
MOL File: 7758-73-8.mol

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5,7-Dihydroxy-4-phenylcoumarin Property

Melting point:: 227-233 °C (lit.)
Boiling point:: 535.5±19.0 °C(Predicted)
Density: 1.443
storage temp.: Store at -20°C
solubility: DMSO: 250 mg/mL (983.32 mM)
pka: 7.09±0.20(Predicted)
form: Solid
color: Light yellow to yellow
InChI: InChI=1S/C15H10O4/c16-10-6-12(17)15-11(9-4-2-1-3-5-9)8-14(18)19-13(15)7-10/h1-8,16-17H
InChIKey: HUQKUJNSVHEHIH-UHFFFAOYSA-N
SMILES: C1(=O)OC2=CC(O)=CC(O)=C2C(C2=CC=CC=C2)=C1

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 578320
Product name: 5,7-Dihydroxy-4-phenylcoumarin
Packaging: 1g
Price: $40.75
Updated: 2025/07/31

Biosynth Carbosynth

Product number: FD124397
Product name: 5,7-Dihydroxy-4-phenyl-2H-chromen-2-one
Packaging: 250mg
Price: $57.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD124397
Product name: 5,7-Dihydroxy-4-phenyl-2H-chromen-2-one
Packaging: 500mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-0106129
Product name: LC3-mHTT-IN-AN2
Packaging: 50mg
Price: $150
Updated: 2021/12/16

Matrix Scientific

Product number: 064833
Product name: 5,7-Dihydroxy-4-phenyl-2H-chromen-2-one
Packaging: 500mg
Price: $158
Updated: 2021/12/16

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5,7-Dihydroxy-4-phenylcoumarin Chemical Properties,Usage,Production

Uses

LC3-mHTT-IN-AN2 (Compound AN2) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN2 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons[1].

References

[1] Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Oct 30. DOI:10.1038/s41586-019-1722-1

5,7-Dihydroxy-4-phenylcoumarin Preparation Products And Raw materials

Raw materials

Preparation Products

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5,7-Dihydroxy-4-phenylcoumarin Suppliers

China 50 Germany 1 India 4 Switzerland 1 United Kingdom 6 United States 9 Global 71

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5,7-DIHYDROXY-4-PHENYLCOUMARIN

LC3-mHTT-IN-AN2, 10 mM in DMSO

7758-73-8

Building Blocks

Coumarins

Heterocyclic Building Blocks

Coumarin

Building Blocks

Chemical Synthesis

Heterocyclic Building Blocks