5,7-Dihydroxy-4-phenylcoumarin
- Product Name
- 5,7-Dihydroxy-4-phenylcoumarin
- CAS No.
- 7758-73-8
- Chemical Name
- 5,7-Dihydroxy-4-phenylcoumarin
- Synonyms
- Serratin;LC3-mHTT-IN-AN2, 10 mM in DMSO;5,7-DIHYDROXY-4-PHENYLCOUMARIN;5,7-dihydroxy-4-phenyl-2-chromenone;5,7-dihydroxy-4-phenylchromen-2-one;5,7-Dihydroxy-4-phenyl-chromen-2-one;5,7-Dihydroxy-4-phenyl-2H-chromen-2-one;5,7-dihydroxy-4-phenyl-1-benzopyran-2-one;5,7-Dihydroxy-4-phenyl-2H-1-benzopyran-2-one;2H-1-Benzopyran-2-one, 5,7-dihydroxy-4-phenyl-
- CBNumber
- CB3505122
- Molecular Formula
- C15H10O4
- Formula Weight
- 254.24
- MOL File
- 7758-73-8.mol
5,7-Dihydroxy-4-phenylcoumarin Property
- Melting point:
- 227-233 °C (lit.)
- Boiling point:
- 535.5±19.0 °C(Predicted)
- Density
- 1.443
- storage temp.
- Store at -20°C
- solubility
- DMSO: 250 mg/mL (983.32 mM)
- pka
- 7.09±0.20(Predicted)
- form
- Solid
- color
- Light yellow to yellow
- InChI
- InChI=1S/C15H10O4/c16-10-6-12(17)15-11(9-4-2-1-3-5-9)8-14(18)19-13(15)7-10/h1-8,16-17H
- InChIKey
- HUQKUJNSVHEHIH-UHFFFAOYSA-N
- SMILES
- C1(=O)OC2=CC(O)=CC(O)=C2C(C2=CC=CC=C2)=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 578320
- Product name
- 5,7-Dihydroxy-4-phenylcoumarin
- Packaging
- 1g
- Price
- $40.75
- Updated
- 2025/07/31
- Product number
- FD124397
- Product name
- 5,7-Dihydroxy-4-phenyl-2H-chromen-2-one
- Packaging
- 250mg
- Price
- $57.5
- Updated
- 2021/12/16
- Product number
- FD124397
- Product name
- 5,7-Dihydroxy-4-phenyl-2H-chromen-2-one
- Packaging
- 500mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- CS-0106129
- Product name
- LC3-mHTT-IN-AN2
- Packaging
- 50mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 064833
- Product name
- 5,7-Dihydroxy-4-phenyl-2H-chromen-2-one
- Packaging
- 500mg
- Price
- $158
- Updated
- 2021/12/16
5,7-Dihydroxy-4-phenylcoumarin Chemical Properties,Usage,Production
Uses
LC3-mHTT-IN-AN2 (Compound AN2) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN2 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons[1].
References
[1] Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Oct 30. DOI:10.1038/s41586-019-1722-1
5,7-Dihydroxy-4-phenylcoumarin Preparation Products And Raw materials
Raw materials
Preparation Products
5,7-Dihydroxy-4-phenylcoumarin Suppliers
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- Country
- Switzerland
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