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OXIDIZED NIFEDIPINE

Product Name
OXIDIZED NIFEDIPINE
CAS No.
67035-22-7
Chemical Name
OXIDIZED NIFEDIPINE
Synonyms
B 4759;BAY-b-4759;Nifedipine-1;Dehydro Nifedipine;NIFEDIPINE EP IMP A;Nifidipine Impurity A;Nitrophenyl nifedipine;Nifedipine impurity A CRS;Nifedipine impurity A (EP);Divalproex Sodium Impurity 1
CBNumber
CB3505238
Molecular Formula
C17H16N2O6
Formula Weight
344.32
MOL File
67035-22-7.mol
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OXIDIZED NIFEDIPINE Property

Melting point:
100-105 °C
Boiling point:
443.7±45.0 °C(Predicted)
Density 
1.284±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
powder
pka
1.55±0.29(Predicted)
color 
yellow
EPA Substance Registry System
3,5-Pyridinedicarboxylic acid, 2,6-dimethyl-4-(2-nitrophenyl)-,3,5-dimethyl ester (67035-22-7)
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Safety

Hazard Codes 
Xi
Risk Statements 
41
Safety Statements 
26-39
WGK Germany 
2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
UC167
Product name
Oxidized Nifedipine
Purity
powder, ~95% (HPLC)
Packaging
5mg
Price
$469
Updated
2024/03/01
Sigma-Aldrich
Product number
1463600
Product name
Nifedipine Nitrophenylpyridine Analog
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25mg
Price
$1530
Updated
2024/03/01
Cayman Chemical
Product number
23229
Product name
Dehydro Nifedipine
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
23229
Product name
Dehydro Nifedipine
Purity
≥98%
Packaging
5mg
Price
$193
Updated
2024/03/01
Sigma-Aldrich
Product number
UC167
Product name
Oxidized Nifedipine
Purity
powder, ~95% (HPLC)
Packaging
10mg
Price
$861
Updated
2024/03/01
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OXIDIZED NIFEDIPINE Chemical Properties,Usage,Production

Description

Dehydro nifedipine is an active metabolite of nifedipine , a calcium channel blocker present in formulations used to treat hypertension and angina. Dehydro nifedipine is formed when nifedipine is metabolized by the cytochrome P450 (CYP) isomers CYP3A4 and CYP3A5. Dehydro nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 μM.

Chemical Properties

Pale Yellow Solid

Uses

Oxidized nifedipine has been used for apoptotic signaling studies in dopaminergic neurons.

Uses

The main Nifedipine metabolite in human plasma

Definition

ChEBI: Dehydronifedipine is a phenylpyridine.

Biochem/physiol Actions

CYP3A4 nifedipine metabolite. Nifedipine (parent compound) is an antianginal and antihypertensive agent.

OXIDIZED NIFEDIPINE Preparation Products And Raw materials

Raw materials

Preparation Products

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OXIDIZED NIFEDIPINE Suppliers

Canada 2 China 94 France 2 India 5 Switzerland 1 United Kingdom 4 United States 11 Global 119
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
Beijing Comparison Pharmaceutical Technology Co., Ltd
Tel
010-010-52878169 15801002657
Email
sales@bjcomparison.com
Country
China
ProdList
5004
Advantage
58
Clearsynth Labs Limited
Tel
+91-22-26355700
Fax
+91-22-26355701
Email
info@clearsynth.com
Country
India
ProdList
9679
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18070
Advantage
56
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7887
Advantage
56
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9906
Advantage
50
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
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View Lastest Price from OXIDIZED NIFEDIPINE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Oxidized Nifedipine 67035-22-7
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2019-12-27

67035-22-7, OXIDIZED NIFEDIPINERelated Search:

Nifedipine METHYL 2-(O-NITROBENZYLIDENE)-ACETOACETATE Methyl 3-aminocrotonate 2,6-Ntp Dehydro Nifedipine N-Oxide diethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Nifedipine Impurity J Hydroxydehydro Nifedipine Carboxylate methyl 2,4-bis{2-nitrophenyl}-6-methyl-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate Nifedipine Impurity 9 2,6-DIMETHYL-4-(3-NITRO-PHENYL)-PYRIDINE-3,5-DICARBOXYLIC ACID DIMETHYL ESTER Nifendipine Impurity G nifedipine iMpurity C Hydroxy Dehydro Nifedipine Lactone 3-aminocrotonamide Nifedipine impurity 10 Nifedipine EP IMpurity-B Nifedipine EP IMpurity-C

  • Nifedipine-1
  • Dimethyl 2,6-Dimethyl-4-(2-nitrophenyl)-3,5-pyridined
  • Nifedipine Impurity Ⅰ:2,6-Dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3,5-Dimethyl Ester
  • 2,6-Dimethyl-4-(2′-nitrophenyl)-3,5-pyridinecarboxylic acid dimethyl ester, Oxidized Nifedipine
  • Divalproex Sodium Impurity 1
  • Nifedipine Nitrophenylpyridine Analog
  • dimethyl 2,6-dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylate
  • Nifedipine impurity A (EP)
  • Dimethyl 4-(2-nitrophenyl)-2,6-dimethylpyridine-3,5-dicarboxylate
  • dimethyl2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate
  • 2,6-Dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3,5-Dimethyl Ester
  • B 4759
  • Dehydro Nifedipine
  • 2,6-Dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylic acid dimethyl ester
  • 4-(2-Nitrophenyl)-2,6-dimethylpyridine-3,5-dicarboxylic acid dimethyl ester
  • BAY-b-4759
  • Nitrophenyl nifedipine
  • Nifedipine Impurity Ⅰ（Dimethyl 2,6-Dimethyl-4-(2-Nitrophenyl)pyridine-3,5-Dicarboxylate）
  • Nifedipine impurity A CRS
  • Dimethyl 2,6-Dimethyl-4-(2-nitrophe
  • Nifedipine EP Impurity A/Dehydro Nifedipine
  • 3,5-Pyridinedicarboxylic acid, 2,6-dimethyl-4-(2-nitrophenyl)-, 3,5-dimethyl ester
  • Nifidipine Impurity A
  • Nifedipine EP Impurity A (Nifedipine nitrophenylpyridine analogue)
  • Azilsartan medoxomil impurity308
  • DehydronifedipineQ: What is Dehydronifedipine Q: What is the CAS Number of Dehydronifedipine Q: What is the storage condition of Dehydronifedipine Q: What are the applications of Dehydronifedipine
  • Nifedipine Impurity Ⅰ:2,6-Dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3,5-Dimethyl Ester
  • Nifedipine nitrophenylpyridine Analogue
  • dimethyl 2,6-dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylate (nitrophenylpyridine analogue)
  • _x000b_Dimethyl 2,6-Dimethyl-4-(2-nitrophenyl)-3,5-pyridined
  • NIFEDIPINE EP IMP A
  • Dehydronifedipine in Acetonitrile
  • Nifedipine EP impurity A Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)pyridine-3,5- dicarboxylate (nitrophenylpyridine analogue)
  • 67035-22-7
  • 34432
  • Various Metabolites and Impurities
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals