OXIDIZED NIFEDIPINE

Product Name: OXIDIZED NIFEDIPINE
CAS No.: 67035-22-7
Chemical Name: OXIDIZED NIFEDIPINE
Synonyms: B 4759;BAY-b-4759;Nifedipine-1;Dehydro Nifedipine;NIFEDIPINE EP IMP A;Nifidipine Impurity A;Nitrophenyl nifedipine;Nifedipine impurity A CRS;Nifedipine impurity A (EP);Divalproex Sodium Impurity 1
CBNumber: CB3505238
Molecular Formula: C17H16N2O6
Formula Weight: 344.32
MOL File: 67035-22-7.mol

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OXIDIZED NIFEDIPINE Property

Melting point:: 100-105 °C
Boiling point:: 443.7±45.0 °C(Predicted)
Density: 1.284±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: powder
pka: 1.55±0.29(Predicted)
color: yellow
EPA Substance Registry System: 3,5-Pyridinedicarboxylic acid, 2,6-dimethyl-4-(2-nitrophenyl)-,3,5-dimethyl ester (67035-22-7)

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Safety

Hazard Codes: Xi
Risk Statements: 41
Safety Statements: 26-39
WGK Germany: 2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H318Causes serious eye damage
Precautionary statements: P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: UC167
Product name: Oxidized Nifedipine
Purity: powder, ~95% (HPLC)
Packaging: 5mg
Price: $482
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHR3778
Product name: Nifedipine Nitrophenylpyridine Analog
Purity: certified reference material, pharmaceutical secondary standard
Packaging: 50MG
Price: $541
Updated: 2025/07/31

Sigma-Aldrich

Product number: N0750010
Product name: Nifedipine impurity A
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 25 mg
Price: $156
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1463600
Product name: Nifedipine Nitrophenylpyridine Analog
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 25mg
Price: $1330
Updated: 2025/07/31

Cayman Chemical

Product number: 23229
Product name: Dehydro Nifedipine
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

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OXIDIZED NIFEDIPINE Chemical Properties,Usage,Production

Description

Dehydro nifedipine is an active metabolite of nifedipine , a calcium channel blocker present in formulations used to treat hypertension and angina. Dehydro nifedipine is formed when nifedipine is metabolized by the cytochrome P450 (CYP) isomers CYP3A4 and CYP3A5. Dehydro nifedipine inhibits glucose uptake in PC-12 cells with an IC₅₀ value of 130 μM.

Chemical Properties

Pale Yellow Solid

Uses

Oxidized nifedipine has been used for apoptotic signaling studies in dopaminergic neurons.

Uses

The main Nifedipine metabolite in human plasma

Definition

ChEBI: Dehydronifedipine is a phenylpyridine.

Biochem/physiol Actions

CYP3A4 nifedipine metabolite. Nifedipine (parent compound) is an antianginal and antihypertensive agent.

References

[1] T. D. ARDIZZONE D D Xiao Hong Lu. Calcium-independent inhibition of glucose transport in PC-12 and L6 cells by calcium channel antagonists.[J]. American journal of physiology. Cell physiology, 2002, 27 1: C579-86. DOI: 10.1152/ajpcell.00451.2001
[2] KIRAN C PATKI D J G Lisa L Von Moltke. In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5.[J]. Drug Metabolism and Disposition, 2003, 31 7: 938-944. DOI: 10.1124/dmd.31.7.938
[3] TETSURO AGO. Nifedipine inhibits cardiac hypertrophy and left ventricular dysfunction in response to pressure overload.[J]. Journal of Cardiovascular Translational Research, 2010, 3 4: 304-313. DOI: 10.1007/s12265-010-9182-x
[4] J. LEMAY. Regression of Neointimal Lesions in the Carotid Artery of Nifedipine-Treated SHR and WKY Rats: Possible Role of Apoptosis[J]. Journal of Vascular Research, 2001, 38 1: 462-470. DOI: 10.1159/000051079

OXIDIZED NIFEDIPINE Preparation Products And Raw materials

Raw materials

Preparation Products

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OXIDIZED NIFEDIPINE Suppliers

Canada 2 China 113 France 2 India 5 Switzerland 1 United Kingdom 4 United States 10 Global 137

Shanghai Weijiahe Biotechnology Co., Ltd

Tel: 17502176150
Email: 861873257@qq.com
Country: China
ProdList: 1654
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Clearsynth Labs Limited

Tel: +91-22-26355700
Fax: +91-22-26355701
Email: info@clearsynth.com
Country: India
ProdList: 9679
Advantage: 58

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18333
Advantage: 56

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
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Country: China
ProdList: 7778
Advantage: 56

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9906
Advantage: 50

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Nanjing XiZe Biotechnology CO., Ltd.

Tel: 025-58362220 0086-15250997978
Fax: 025-58362220
Email: sale@njxizebio.com
Country: China
ProdList: 4855
Advantage: 55

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View Lastest Price from OXIDIZED NIFEDIPINE manufacturers

Moxin Chemicals

Product: Nifedipine EP Impurity A 67035-22-7
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 99%+ HPLC
Supply Ability: 1000
Release date: 2025-06-30

Shaanxi Dideu Medichem Co. Ltd

Product: Oxidized Nifedipine 67035-22-7
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2019-12-27

67035-22-7, OXIDIZED NIFEDIPINERelated Search:

Nifedipine METHYL 2-(O-NITROBENZYLIDENE)-ACETOACETATE Methyl 3-aminocrotonate 2,6-Ntp Dehydro Nifedipine N-Oxide diethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Nifedipine Impurity J Hydroxydehydro Nifedipine Carboxylate methyl 2,4-bis{2-nitrophenyl}-6-methyl-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate Nifedipine Impurity 9 2,6-DIMETHYL-4-(3-NITRO-PHENYL)-PYRIDINE-3,5-DICARBOXYLIC ACID DIMETHYL ESTER Nifendipine Impurity G nifedipine iMpurity C Hydroxy Dehydro Nifedipine Lactone 3-aminocrotonamide Nifedipine impurity 10 Nifedipine EP IMpurity-B Nifedipine EP IMpurity-C

Nifedipine-1

Dimethyl 2,6-Dimethyl-4-(2-nitrophenyl)-3,5-pyridined

Nifedipine Impurity Ⅰ:2,6-Dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3,5-Dimethyl Ester

2,6-Dimethyl-4-(2′-nitrophenyl)-3,5-pyridinecarboxylic acid dimethyl ester, Oxidized Nifedipine

Divalproex Sodium Impurity 1

Nifedipine Nitrophenylpyridine Analog

dimethyl 2,6-dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylate

Nifedipine impurity A (EP)

Dimethyl 4-(2-nitrophenyl)-2,6-dimethylpyridine-3,5-dicarboxylate

dimethyl2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate

2,6-Dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3,5-Dimethyl Ester

B 4759

Dehydro Nifedipine

2,6-Dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylic acid dimethyl ester

4-(2-Nitrophenyl)-2,6-dimethylpyridine-3,5-dicarboxylic acid dimethyl ester

BAY-b-4759

Nitrophenyl nifedipine

Nifedipine Impurity Ⅰ（Dimethyl 2,6-Dimethyl-4-(2-Nitrophenyl)pyridine-3,5-Dicarboxylate）

Nifedipine impurity A CRS

Dimethyl 2,6-Dimethyl-4-(2-nitrophe

Nifedipine EP Impurity A/Dehydro Nifedipine

3,5-Pyridinedicarboxylic acid, 2,6-dimethyl-4-(2-nitrophenyl)-, 3,5-dimethyl ester

Nifidipine Impurity A

Nifedipine EP Impurity A (Nifedipine nitrophenylpyridine analogue)

Azilsartan medoxomil impurity308

DehydronifedipineQ: What is Dehydronifedipine Q: What is the CAS Number of Dehydronifedipine Q: What is the storage condition of Dehydronifedipine Q: What are the applications of Dehydronifedipine

Nifedipine nitrophenylpyridine Analogue

dimethyl 2,6-dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylate (nitrophenylpyridine analogue)

_x000b_Dimethyl 2,6-Dimethyl-4-(2-nitrophenyl)-3,5-pyridined

NIFEDIPINE EP IMP A

Dehydronifedipine in Acetonitrile

Nifedipine EP impurity A Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)pyridine-3,5- dicarboxylate (nitrophenylpyridine analogue)

Dimethyl 2,6-Dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylate (Nitrophenylpyridine Analogue of N

Dimethyl 2,6-Dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylate (Nitrophenylpyridine Analogue of Nifedipine)

Dehydronifedipine 100 μg/mL in Acetonitrile

67035-22-7

34432

Various Metabolites and Impurities

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals