Chelerythrine

ChemicalBook > CAS DataBase List > Chelerythrine

Description References

Product Name: Chelerythrine
CAS No.: 34316-15-9
Chemical Name: Chelerythrine
Synonyms: Cheleritrine;helerythrine;CHELERYTHRINE;Einecs 251-930-0;Broussonpapyrine;Chelerythrine (6CI);478-03-5 (Hydroxide);3895-92-9 (Chloride);Chelerythrine chlori;Chelerythrine chloride
CBNumber: CB3506907
Molecular Formula: C21H18NO4+
Formula Weight: 348.37192
MOL File: 34316-15-9.mol

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Chelerythrine Property

Melting point:: 195-205°C
Boiling point:: 496.37°C (rough estimate)
Density: 1.2985 (rough estimate)
refractive index: 1.5614 (estimate)
storage temp.: Desiccate at -20°C
solubility: Chloroform (Slightly, Sonicated), DMSO (Slightly, Sonicated), Methanol (Slightly）
form: Solid
color: Light Yellow to Dark Orange
Stability:: Hygroscopic
LogP: -0.401 (est)
CAS DataBase Reference: 34316-15-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22
Safety Statements: 36/37

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris

Product number: 1330
Product name: Chelerythrine chloride
Purity: ≥98%(HPLC)
Packaging: 5
Price: $159
Updated: 2021/12/16

Usbiological

Product number: C3889-10
Product name: Chelerythrine Chloride
Packaging: 5mg
Price: $216
Updated: 2021/12/16

Usbiological

Product number: 044663
Product name: Chelerythrine chloride
Packaging: 1mg
Price: $269
Updated: 2021/12/16

Usbiological

Product number: 169656
Product name: Chelerythrine Chloride
Packaging: 5mg
Price: $340
Updated: 2021/12/16

Usbiological

Product number: 254958
Product name: Chelerythrine chloride
Packaging: 5mg
Price: $403
Updated: 2021/12/16

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Chelerythrine Chemical Properties,Usage,Production

Description

Chelerythrine chloride is the chloride form of Chelerythrine chloride which is a benzophenanthridine alkaloid isolated from the plant Chelidonium majus (greater celandine). It is a kind of potent, selective, and cell-permeable protein kinase C inhibitor, an efficient antagonist of G-protein-coupled CB1 receptors, and an independent activator of MAPK pathways. It has a wide range of biological activities including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. It has reported of that it is capable of inducing apoptosis in HL-60 human promyelocytic leukemia cells and several other cancer cell lines. The underlying mechanism is through its effects of inhibiting the binding of BclXL to Bax or Bad.

References

https://en.wikipedia.org/wiki/Chelerythrine
https://www.scbt.com/scbt/product/chelerythrine-chloride-3895-92-9
https://www.tocris.com/dispprod.php?ItemId=2342#.WQmZVVNsgZQ

Uses

Chelerythrine Chloride is a cell permeable protein kinase C (PKC) inhibitor.

Definition

ChEBI: A benzophenanthridine alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae.

Biological Activity

Potent, cell-permeable inhibitor of protein kinase C (IC 50 = 660 nM); competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Has a wide range of biological activities, including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. Activates MAPK pathways, independent of PKC inhibition. Inhibits binding of BclXL to Bak (IC 50 = 1.5 μ M) or Bad proteins and stimulates apoptosis.

Purification Methods

Chelerythrine crystallises from CHCl3 on addition of MeOH [Manske Can J Res 21B 140 1943, UV: Hruban et al. Coll Czech Chem Commun 35 3420 1970]. The pseudo base is colourless while the salts are yellow in aqueous solution and are fluorescent.

Chelerythrine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Chelerythrine manufacturers

Changsha Staherb Natural Ingredients Co., Ltd.

Product: Chelerythrine; Chelerythrine chloride 34316-15-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 1%-98% HPLC
Supply Ability: 1000KG
Release date: 2022-09-30

Shanghai Standard Technology Co., Ltd.

Product: Chelerythrine 34316-15-9
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-09-27

Zhuozhou Wenxi import and Export Co., Ltd

Product: chelerythrine 34316-15-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

34316-15-9, ChelerythrineRelated Search:

METSULFURON METHYL Methylparaben Zinc chloride Choline chloride Potassium chloride Sodium chloride Methyl acetate Methyl acrylate Calcium chloride Bensulfuron methyl Oxalyl chloride Thiophanate-methyl Kresoxim-methyl Thionyl chloride Ammonium chloride Methyl Parathion-methyl CHELERYTHRINE CHLORIDE(RG)

1,2-Dimethoxy-N-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride

Chelerythrine chloride

CHELERYTHRINE(TODDALINE)(RG)

1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium

chelerythrine/toddaline

1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium

2,3-(Epoxymethanoxy)-5-methyl-7,8-dimethoxybenzo[c]phenanthridine-5-ium

Cheleritrine

3895-92-9 (Chloride)

478-03-5 (Hydroxide)

Einecs 251-930-0

Broussonpapyrine

helerythrine

17,18-DIMETHOXY-21-METHYL-5,7-DIOXA-21-AZAPENTACYCLO[11.8.0.0^{2,10}.0^{4,8}.0^{14,19}]HENICOSA-1(13),2,4(8),9,11,14,16,18,20-NONAEN-21-IUM

Chelerythrine, 98%, from Macleaya cordata (Willd.) R. Br.

CHELERYTHRINE

Chelerythrine USP/EP/BP

Chelerythrine DISCONTINUED. Please see C291880.

[1,3]Dioxolo[4',5':4,5]benzo[1,2-c]phenanthridinium,1,2-dimethoxy-12-methyl-

Chelerythrine chlori

1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin...

Chelerythrine (6CI)

1,2-Dimethoxy-12-methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-12-ium

Sibutramine Impurity 7

34316-15-9

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Natural Plant Extract