CHELERYTHRINE CHLORIDE

Product Name: CHELERYTHRINE CHLORIDE
CAS No.: 3895-92-9
Chemical Name: CHELERYTHRINE CHLORIDE
Synonyms: 1,2-diMethoxy-12-Methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-12-iuM chloride;TODDALIN;CHELERYTHRIN CL;Chelerythrine Cl;TODDALIN CHLORIDE;CHELERYTHRIN CHLORIDE;Chelerythrine cloride;Chelerythrine chloride;CHELERYTHRINE CHLORIDE(P);CHELERYTHRINE CHLORIDE(RG)
CBNumber: CB3760820
Molecular Formula: C21H18ClNO4
Formula Weight: 383.82
MOL File: 3895-92-9.mol

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CHELERYTHRINE CHLORIDE Property

Melting point:: 195-205 °C
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO: ≥10 mg/mL
form: powder
color: yellow to orange
Stability:: Hygroscopic
InChIKey: WEEFNMFMNMASJY-UHFFFAOYSA-M

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 20/21/22-36/37/38-36/37
Safety Statements: 26-36-36/37
RIDADR: UN 1544PSN1 6.1 / PGII
WGK Germany: 3
RTECS: FL9200000
HS Code: 29349990
Toxicity: mouse,LD50,intravenous,18500ug/kg (18.5mg/kg),Planta Medica. Vol. 43, Pg. 161, 1981.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0002288
Product name: Chelerythrine chloride
Purity: CRS, European Pharmacopoeia (EP) Reference Standard
Packaging: Y0002288
Price: $152
Updated: 2024/03/01

Sigma-Aldrich

Product number: C2932
Product name: Chelerythrine chloride
Purity: ≥95% (TLC), powder
Packaging: 1mg
Price: $66.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: 220285
Product name: Chelerythrine Chloride
Purity: Naturally-occurring alkaloid.
Packaging: 5mg
Price: $187
Updated: 2024/03/01

Alfa Aesar

Product number: J62906
Product name: Chelerythrine chloride, 99+%
Packaging: 5mg
Price: $130.65
Updated: 2024/03/01

Alfa Aesar

Product number: J62906
Product name: Chelerythrine chloride, 99+%
Packaging: 10mg
Price: $200.65
Updated: 2024/03/01

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CHELERYTHRINE CHLORIDE Chemical Properties,Usage,Production

Description

Chelerythrine is a potent, cell permeable inhibitor of protein kinase C (IC₅₀ = 660 nM) that does not inhibit tyrosine protein kinases, cAMP-dependent protein kinase, or calcium/calmodulin-dependent protein kinase. Chelerythrine also inhibits Bcl-xL function (IC₅₀ = 1.5 μM) by displacing Bax binding, inducing apoptosis in several cancer cell lines. Chelerythrine can also have PKC-independent effects, activate p38 MAP kinase and JUNK signaling pathways, and induce apoptosis in cancer cells both in vitro and in vivo.

Chemical Properties

yellow to orange solid

Uses

Chelerythrine Chloride is a cell permeable protein kinase C (PKC) inhibitor.

General Description

Naturally occurring alkaloid. Cell-permeable, selective inhibitor of protein kinase C (IC₅₀ = 660 nM). Acts on the catalytic domain irrespective of the attachment of the regulatory domain. Material is a competitive inhibitor with respect to the phosphate acceptor and a non-competitive inhibitor with respect to ATP. Over ten-fold more potent than H-7, HCl (Cat. No. 371955). Inhibits thromboxane formation and phosphoinositide metabolism in platelets. Also induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells.

Biochem/physiol Actions

Cell permeable: yes

storage

-20°C (desiccate)

References

1. j. m. herbert, j. m. augereau, j. gleye and j. p. maffrand, biochem biophys res commun 1990, 172, 993-999. 2. w. d. jarvis, a. j. turner, l. f. povirk, r. s. traylor and s. grant, cancer res 1994, 54, 1707-1714. 3. j. vrba, p. dolezel, j. vicar, m. modriansky and j. ulrichova, toxicol in vitro 2008, 22, 1008-1017. 4. m. vogler, k. weber, d. dinsdale, i. schmitz, k. schulze-osthoff, m. j. dyer and g. m. cohen, cell death differ 2009, 16, 1030-1039. 5. r. yu, s. mandlekar, t. h. tan and a. n. kong, j biol chem 2000, 275, 9612-9619. 6. s. yamamoto, k. seta, c. morisco, s. f. vatner and j. sadoshima, j mol cell cardiol 2001, 33, 1829-1848.

CHELERYTHRINE CHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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CHELERYTHRINE CHLORIDE Suppliers

Australia 1 Belgium 1 China 150 Europe 2 France 2 Germany 8 India 6 Japan 3 Switzerland 2 United Kingdom 13 United States 38 Global 226

J & K SCIENTIFIC LTD.

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Spectrum Chemical Manufacturing Corp.

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Dalian Meilun Biotech Co., Ltd.

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Chengdu Biopurify Phytochemicals Ltd.

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View Lastest Price from CHELERYTHRINE CHLORIDE manufacturers

Career Henan Chemical Co

Product: CHELERYTHRINE CHLORIDE 3895-92-9
Price: US $1.00-1.00/kg
Min. Order: 1 mg
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-25

3895-92-9, CHELERYTHRINE CHLORIDERelated Search:

GF109203X GO 6976 D-ERYTHRO-SPHINGOSINE GANGLIOSIDE GD1A DISODIUM SALT BISINDOLYLMALEIMIDE II BISINDOLYLMALEIMIDE VII 2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether Chloromethane Chrysene Chelerythrine 2,3-Dihydroxynaphthalene 8-Isoquinolinol 7-Hydroxyisoquinoline Phenanthridine CHELERYTHRINE CHLORIDE 7,8-BENZOQUINOLINE 7-METHOXY-ISOQUINOLINE 8-Methoxyisoquinoline

TODDALIN

TODDALIN CHLORIDE

3)benzodioxolo(5,6-c)phenanthridinium,1,2-dimethoxy-12-methyl-(chloride

chelerythrinehydrochloride

1,2-DIMETHOXY-12,[1,3]-BENZODIOXOLO[5,6-C]PHENANTHRIDINIUM CHLORIDE

1,2-DIMETHOXY-12-METHYL[1,3]BENZODIOXOLO[5,6-C]PHENANTHRIDINIUM CHLORIDE

CHELERYTHRIN CHLORIDE

CHELERYTHRIN CL

Chelerythrine cloride

[1,3]Benzodioxolo[5,6-c]phenanthridinium, 1,2-dimethoxy-12-methyl-, chloride (1:1)

CHELERYTHRINE CHLORIDE(RG)

Chelerythrine Chloride - CAS 3895-92-9 - Calbiochem

Chelerythrine chloride,98%

Chelerythrine chloride1,2-Dimethoxy-N-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride

Chelerythrine chloride

1,2-Dimethoxy-N-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride

[1,3]Benzodioxolo[5,6-c]phenanthridiniuM, 1,2-diMethoxy-12-Methyl-, chloride

CHELERYTHRINE CHLORIDE(P)

1,2-diMethoxy-12-Methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-12-iuM chloride

Chelerythrine Cl

17,18-dimethoxy-21-methyl-5,7-dioxa-21-azapentacyclo[11.8.0.02,1.0,.01,1]henicosa-1(13),2,4(8),9,11,14,16,18,20-nonaen-21-ium chloride

1,2-Dimethoxy-12-methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-12-ium chloride

3895-92-9

16732-75-2

C21H18ClNO4

C12H18NO4

C21H18NO4Cl

BioChemical

Cell Biology

Cell Signaling and Neuroscience

Kinase/Phosphatase Biology

Protein Kinase C (PKC)

Serine/Threonine Kinase Inhibitors

antibiotic

Herb extract

Alkaloids

Protein Kinase