Description References
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Chelerythrine

Description References
Product Name
Chelerythrine
CAS No.
34316-15-9
Chemical Name
Chelerythrine
Synonyms
Cheleritrine;helerythrine;CHELERYTHRINE;Einecs 251-930-0;Broussonpapyrine;Chelerythrine (6CI);478-03-5 (Hydroxide);3895-92-9 (Chloride);Chelerythrine chlori;Chelerythrine chloride
CBNumber
CB3506907
Molecular Formula
C21H18NO4+
Formula Weight
348.37192
MOL File
34316-15-9.mol
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Chelerythrine Property

Melting point:
195-205°C
Boiling point:
496.37°C (rough estimate)
Density 
1.2985 (rough estimate)
refractive index 
1.5614 (estimate)
storage temp. 
Desiccate at -20°C
solubility 
Chloroform (Slightly, Sonicated), DMSO (Slightly, Sonicated), Methanol (Slightly)
form 
Solid
color 
Light Yellow to Dark Orange
Stability:
Hygroscopic
LogP
-0.401 (est)
CAS DataBase Reference
34316-15-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
36/37
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris
Product number
1330
Product name
Chelerythrine chloride
Purity
≥98%(HPLC)
Packaging
5
Price
$159
Updated
2021/12/16
Usbiological
Product number
044663
Product name
Chelerythrine chloride
Packaging
1mg
Price
$269
Updated
2021/12/16
Usbiological
Product number
169656
Product name
Chelerythrine Chloride
Packaging
5mg
Price
$340
Updated
2021/12/16
Usbiological
Product number
254958
Product name
Chelerythrine chloride
Packaging
5mg
Price
$403
Updated
2021/12/16
Usbiological
Product number
C3889-10
Product name
Chelerythrine Chloride
Packaging
5mg
Price
$216
Updated
2021/12/16
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Chelerythrine Chemical Properties,Usage,Production

Description

Chelerythrine chloride is the chloride form of Chelerythrine chloride which is a benzophenanthridine alkaloid isolated from the plant Chelidonium majus (greater celandine). It is a kind of potent, selective, and cell-permeable protein kinase C inhibitor, an efficient antagonist of G-protein-coupled CB1 receptors, and an independent activator of MAPK pathways. It has a wide range of biological activities including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. It has reported of that it is capable of inducing apoptosis in HL-60 human promyelocytic leukemia cells and several other cancer cell lines. The underlying mechanism is through its effects of inhibiting the binding of BclXL to Bax or Bad.

References

https://en.wikipedia.org/wiki/Chelerythrine
https://www.scbt.com/scbt/product/chelerythrine-chloride-3895-92-9
https://www.tocris.com/dispprod.php?ItemId=2342#.WQmZVVNsgZQ

Uses

Chelerythrine Chloride is a cell permeable protein kinase C (PKC) inhibitor.

Definition

ChEBI: A benzophenanthridine alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae.

Biological Activity

Potent, cell-permeable inhibitor of protein kinase C (IC 50 = 660 nM); competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Has a wide range of biological activities, including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. Activates MAPK pathways, independent of PKC inhibition. Inhibits binding of BclXL to Bak (IC 50 = 1.5 μ M) or Bad proteins and stimulates apoptosis.

Purification Methods

Chelerythrine crystallises from CHCl3 on addition of MeOH [Manske Can J Res 21B 140 1943, UV: Hruban et al. Coll Czech Chem Commun 35 3420 1970]. The pseudo base is colourless while the salts are yellow in aqueous solution and are fluorescent.

Chelerythrine Preparation Products And Raw materials

Raw materials

Preparation Products

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Chelerythrine Suppliers

Chengdu Herbpurify Co.Ltd.
Tel
18302802153 18981717076
Fax
086-28-85377358
Email
2355253619@qq.com
Country
China
ProdList
1104
Advantage
58
Nanjing Dasf Biotechnology Co., Ltd.
Tel
025-+86-02585846866 +86-18094231287
Fax
025-83144123
Email
eric@dasfbio.com
Country
China
ProdList
1988
Advantage
58
Nanjing puyi biotechnology co., LTD
Tel
025-58886740; 13814510036
Email
927565933@qq.com
Country
China
ProdList
1931
Advantage
58
Huzhou ZhanShu Biotechnology Co.,Ltd
Tel
0572-8889530 18167260939
Email
zsubio@163.com
Country
China
ProdList
361
Advantage
58
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8418
Advantage
55
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
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View Lastest Price from Chelerythrine manufacturers

Changsha Staherb Natural Ingredients Co., Ltd.
Product
Chelerythrine; Chelerythrine chloride 34316-15-9
Price
US $0.00/KG
Min. Order
1KG
Purity
1%-98% HPLC
Supply Ability
1000KG
Release date
2022-09-30
Shanghai Standard Technology Co., Ltd.
Product
Chelerythrine 34316-15-9
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-09-27
Zhuozhou Wenxi import and Export Co., Ltd
Product
chelerythrine 34316-15-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-26

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