Chelerythrine
Description References- Product Name
- Chelerythrine
- CAS No.
- 34316-15-9
- Chemical Name
- Chelerythrine
- Synonyms
- Cheleritrine;helerythrine;CHELERYTHRINE;Einecs 251-930-0;Broussonpapyrine;Chelerythrine (6CI);478-03-5 (Hydroxide);3895-92-9 (Chloride);Chelerythrine chlori;Chelerythrine chloride
- CBNumber
- CB3506907
- Molecular Formula
- C21H18NO4+
- Formula Weight
- 348.37192
- MOL File
- 34316-15-9.mol
Chelerythrine Property
- Melting point:
- 195-205°C
- Boiling point:
- 496.37°C (rough estimate)
- Density
- 1.2985 (rough estimate)
- refractive index
- 1.5614 (estimate)
- storage temp.
- Desiccate at -20°C
- solubility
- Chloroform (Slightly, Sonicated), DMSO (Slightly, Sonicated), Methanol (Slightly）
- form
- Solid
- color
- Light Yellow to Dark Orange
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C21H18NO4/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22/h4-10H,11H2,1-3H3/q+1
- InChIKey
- LLEJIEBFSOEYIV-UHFFFAOYSA-N
- SMILES
- C[N+]1=CC2=C(C(OC)=CC=C2C2C=CC3C=C4OCOC4=CC=3C1=2)OC
- LogP
- -0.401 (est)
- CAS DataBase Reference
- 34316-15-9(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 1330
- Product name
- Chelerythrine chloride
- Purity
- ≥98%(HPLC)
- Packaging
- 5
- Price
- $159
- Updated
- 2021/12/16
- Product number
- 044663
- Product name
- Chelerythrine chloride
- Packaging
- 1mg
- Price
- $269
- Updated
- 2021/12/16
- Product number
- 169656
- Product name
- Chelerythrine Chloride
- Packaging
- 5mg
- Price
- $340
- Updated
- 2021/12/16
- Product number
- 254958
- Product name
- Chelerythrine chloride
- Packaging
- 5mg
- Price
- $403
- Updated
- 2021/12/16
- Product number
- C3889-10
- Product name
- Chelerythrine Chloride
- Packaging
- 5mg
- Price
- $216
- Updated
- 2021/12/16
Chelerythrine Chemical Properties,Usage,Production
Description
Chelerythrine chloride is the chloride form of Chelerythrine chloride which is a benzophenanthridine alkaloid isolated from the plant Chelidonium majus (greater celandine). It is a kind of potent, selective, and cell-permeable protein kinase C inhibitor, an efficient antagonist of G-protein-coupled CB1 receptors, and an independent activator of MAPK pathways. It has a wide range of biological activities including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. It has reported of that it is capable of inducing apoptosis in HL-60 human promyelocytic leukemia cells and several other cancer cell lines. The underlying mechanism is through its effects of inhibiting the binding of BclXL to Bax or Bad.
References
https://en.wikipedia.org/wiki/Chelerythrine
https://www.scbt.com/scbt/product/chelerythrine-chloride-3895-92-9
https://www.tocris.com/dispprod.php?ItemId=2342#.WQmZVVNsgZQ
Chemical Properties
Soluble in methanol and ethanol, with some solubility in water, insoluble in petroleum ether, chloroform and other solvents. Derived from the roots and leaves of Flying Dragon's Palm Blood [Toddalia asiatica (L.) Lam.
Uses
Chelerythrine Chloride is a cell permeable protein kinase C (PKC) inhibitor.
Definition
ChEBI: A benzophenanthridine alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae.
Biological Activity
Potent, cell-permeable inhibitor of protein kinase C (IC 50 = 660 nM); competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Has a wide range of biological activities, including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. Activates MAPK pathways, independent of PKC inhibition. Inhibits binding of BclXL to Bak (IC 50 = 1.5 μ M) or Bad proteins and stimulates apoptosis.
in vivo
Chelerythrine (5 mg/kg, i.p., daily) attenuates partial unilateral ureteral obstruction (UUO) induced kidney injury, and restores renal function in neonatal rats[2].
Chelerythrine (1-10 mg/kg, i.p., at 24 and 1 h before injection of 100 μg/kg LPS) shows anti-inflammatory effects (increased survival rate, decreased serum nitrite and TNF-α level) in LPS induced mice endotoxic shock model[5].
| Animal Model: | Unilateral ureteral obstruction (UUO) induced neonatal rats[2] |
| Dosage: | 5 mg/kg |
| Administration: | i.p., daily |
| Result: | Attenuated kidney injury (Increased kidney weight and restored renal function). Inhibited UUO-induced upregulated kidney injury molecule-1 expression, apoptosis, and renal fibrosis. |
IC 50
PKC: 0.7 μM (IC50)
Purification Methods
Chelerythrine crystallises from CHCl3 on addition of MeOH [Manske Can J Res 21B 140 1943, UV: Hruban et al. Coll Czech Chem Commun 35 3420 1970]. The pseudo base is colourless while the salts are yellow in aqueous solution and are fluorescent.
Chelerythrine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Chelerythrine manufacturers
- Product
- Chelerythrine; Chelerythrine chloride 34316-15-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 1%-98% HPLC
- Supply Ability
- 1000KG
- Release date
- 2022-09-30
- Product
- Chelerythrine 34316-15-9
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2019-09-27
- Product
- chelerythrine 34316-15-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-26