CHELERYTHRINE CHLORIDE
- Product Name
- CHELERYTHRINE CHLORIDE
- CAS No.
- 3895-92-9
- Chemical Name
- CHELERYTHRINE CHLORIDE
- Synonyms
- 1,2-diMethoxy-12-Methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-12-iuM chloride;TODDALIN;CHELERYTHRIN CL;Chelerythrine Cl;TODDALIN CHLORIDE;CHELERYTHRIN CHLORIDE;Chelerythrine cloride;Chelerythrine chloride;CHELERYTHRINE CHLORIDE(P);CHELERYTHRINE CHLORIDE(RG)
- CBNumber
- CB3760820
- Molecular Formula
- C21H18ClNO4
- Formula Weight
- 383.82
- MOL File
- 3895-92-9.mol
CHELERYTHRINE CHLORIDE Property
- Melting point:
- 195-205 °C
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO: ≥10 mg/mL
- form
- powder
- color
- yellow to orange
- Stability:
- Hygroscopic
- InChIKey
- WEEFNMFMNMASJY-UHFFFAOYSA-M
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22-36/37/38-36/37
- Safety Statements
- 26-36-36/37
- RIDADR
- UN 1544PSN1 6.1 / PGII
- WGK Germany
- 3
- RTECS
- FL9200000
- HS Code
- 29349990
- Toxicity
- mouse,LD50,intravenous,18500ug/kg (18.5mg/kg),Planta Medica. Vol. 43, Pg. 161, 1981.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- Y0002288
- Product name
- Chelerythrine chloride
- Purity
- CRS, European Pharmacopoeia (EP) Reference Standard
- Packaging
- Y0002288
- Price
- $152
- Updated
- 2024/03/01
- Product number
- C2932
- Product name
- Chelerythrine chloride
- Purity
- ≥95% (TLC), powder
- Packaging
- 1mg
- Price
- $66.8
- Updated
- 2024/03/01
- Product number
- 220285
- Product name
- Chelerythrine Chloride
- Purity
- Naturally-occurring alkaloid.
- Packaging
- 5mg
- Price
- $187
- Updated
- 2024/03/01
- Product number
- J62906
- Product name
- Chelerythrine chloride, 99+%
- Packaging
- 5mg
- Price
- $130.65
- Updated
- 2024/03/01
- Product number
- J62906
- Product name
- Chelerythrine chloride, 99+%
- Packaging
- 10mg
- Price
- $200.65
- Updated
- 2024/03/01
CHELERYTHRINE CHLORIDE Chemical Properties,Usage,Production
Description
Chelerythrine is a potent, cell permeable inhibitor of protein kinase C (IC50 = 660 nM) that does not inhibit tyrosine protein kinases, cAMP-
Chemical Properties
yellow to orange solid
Uses
Chelerythrine Chloride is a cell permeable protein kinase C (PKC) inhibitor.
General Description
Naturally occurring alkaloid. Cell-permeable, selective inhibitor of protein kinase C (IC50 = 660 nM). Acts on the catalytic domain irrespective of the attachment of the regulatory domain. Material is a competitive inhibitor with respect to the phosphate acceptor and a non-competitive inhibitor with respect to ATP. Over ten-fold more potent than H-7, HCl (Cat. No. 371955). Inhibits thromboxane formation and phosphoinositide metabolism in platelets. Also induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells.
Biochem/physiol Actions
Cell permeable: yes
storage
-20°C (desiccate)
References
1. j. m. herbert, j. m. augereau, j. gleye and j. p. maffrand, biochem biophys res commun 1990, 172, 993-999. 2. w. d. jarvis, a. j. turner, l. f. povirk, r. s. traylor and s. grant, cancer res 1994, 54, 1707-1714. 3. j. vrba, p. dolezel, j. vicar, m. modriansky and j. ulrichova, toxicol in vitro 2008, 22, 1008-1017. 4. m. vogler, k. weber, d. dinsdale, i. schmitz, k. schulze-osthoff, m. j. dyer and g. m. cohen, cell death differ 2009, 16, 1030-1039. 5. r. yu, s. mandlekar, t. h. tan and a. n. kong, j biol chem 2000, 275, 9612-9619. 6. s. yamamoto, k. seta, c. morisco, s. f. vatner and j. sadoshima, j mol cell cardiol 2001, 33, 1829-1848.
CHELERYTHRINE CHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from CHELERYTHRINE CHLORIDE manufacturers
- Product
- CHELERYTHRINE CHLORIDE 3895-92-9
- Price
- US $1.00-1.00/kg
- Min. Order
- 1 mg
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-12-25