Docetaxel trihydrate

Pharmacology Tolerability

Product Name: Docetaxel trihydrate
CAS No.: 148408-66-6
Chemical Name: Docetaxel trihydrate
Synonyms: Xrp6976;Taxespira;Unii-15H5577cqd;DOCETAXEL HYDRATE;Docetaxel (200 mg);Taxotere Trihydrate;Docetaxel (1224551);Docetaxel trihydrate;Docetaxel Tryhydrate;Docetaxel(trihydrous)
CBNumber: CB3511420
Molecular Formula: C43H55NO15
Formula Weight: 825.91
MOL File: 148408-66-6.mol

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Docetaxel trihydrate Property

Melting point:: 186-192°C
storage temp.: 2-8°C
solubility: Practically insoluble in water, freely soluble in anhydrous ethanol, soluble in methylene chloride.
form: Solid
color: White to OFf-White
Stability:: Hygroscopic
InChIKey: XCDIRYDKECHIPE-KHDBCEGQSA-N
CAS DataBase Reference: 148408-66-6(CAS DataBase Reference)

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Safety

WGK Germany: 3
HS Code: 2932996560

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0001155
Product name: Docetaxel for system suitability
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 15 mg
Price: $156
Updated: 2025/07/31

Sigma-Aldrich

Product number: Y0001133
Product name: Docetaxel trihydrate
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 160 mg
Price: $236
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHR1883
Product name: Docetaxel trihydrate
Packaging: 200mg
Price: $349.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1224551
Product name: Docetaxel for system suitability
Packaging: 200mg
Price: $3050
Updated: 2025/07/31

Sigma-Aldrich

Product number: Y0001155
Product name: Docetaxel for system suitability
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0001155
Price: $153
Updated: 2024/03/01

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Docetaxel trihydrate Chemical Properties,Usage,Production

Pharmacology

Docetaxel principally exerts its cytotoxic activity by promoting and stabilising microtubule assembly while simultaneously preventing microtubule depolymerisation. This results in inhibition of normal cell division. In vitro and in vivo, docetaxel has antineoplastic activity against a wide range of cancer cells, demonstrates synergistic activity with several antineoplastic agents and often has greater cytotoxic activity against human breast cancer cell lines than paclitaxel. Docetaxel, binds to and stabilizes tubulin, which prevents physiological microtubule depolymerization/disassembly and results in cell-cycle arrest at the G2/M phase and cell death. This agent also is known to inhibit the anti-apoptotic gene Bcl2 and to encourage the expression of p27, a cell-cycle inhibitor, and further pro-angiogenic factors such as vascular endothelial growth factor (VEGF). Docetaxel is mainly metabolized in the liver by the cytochrome P450 CYP3A4 and CYP3A5 subfamilies of isoenzymes, and its clearance has been shown to be related to body surface area and hepatic enzyme and alpha1 acid glycoprotein plasma levels.

Tolerability

The tolerability of docetaxel in comparative clinical trials was generally acceptable. Severe neutropenia affects most docetaxel recipients, with febrile neutropenia occurring in approximately one-eighth of patients. Dose-cumulative severe fluid retention was reported in docetaxel recipients, despite premedication with prophylactic corticosteroids. Other adverse events include asthenia, stomatitis, infections, neurosensory, cutaneous or gastrointestinal events, nail changes, severe fever in the absence of infection, myalgia and hypersensitivity reactions.

Chemical Properties

White Crystalline Powder

Uses

An antineoplastic. An antimitotic agent that promotes the assembly of microtublules and inhibits their depolymerization to free tubulin

Uses

Docetaxel Trihydrate is an anti-cancer drugs; Semisynthetic analog of the taxane paclitaxel.

Definition

ChEBI: The trihydrate form of docetaxel. It is used for the treatment of breast, ovarian, and non-small cell lung cancer, and with prednisone or prednisolone in hormone-refractory metastatic prostate cancer.

brand name

Taxotere (Sanofi Aventis).

in vivo

In female mice, the Docetaxel Trihydrate (RP-56976 Trihydrate)-induced intestinal apoptosis in the 14-hours after light on (HALO) group is significantly greater than that in the 2-HALO group. Bax expression is significantly elevated by Docetaxel in the 2-HALO group, but not in the 14-HALO group. On the other hand, cleaved Caspase-3 expression is significantly elevated by Docetaxel in the 14-HALO group, but not in the 2-HALO group. The expressions of Wee1 and phosphorylated CKD1 are significantly elevated after dosing of Docetaxel at 14 HALO, but not at 2 HALO. In addition, Docetaxel significantly reduces survivin expression in the 14-HALO group but not in the 2-HALO group. The survivin expression level in the Docetaxel-treated 14-HALO group is significantly smaller than that in the drug-treated 2-HALO group^[3]. Piperine (PIP) is administrated via intravenous bolus at 3.5 mg/kg and via oral administration at 35 mg/kg and 3.5 mg/kg, while Docetaxel (DOX) is intravenously administrated at 7 mg/kg to Sprague-Daley rats. The co-administrations of PIP at 35 mg/kg via oral administration and Docetaxel at 7 mg/kg via intravenous bolus administration in Sprague-Dawley rats. The combination use of PIP and Docetaxel results in a synergic increase of both their in vivo exposure^[4].

Docetaxel trihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Docetaxel trihydrate Suppliers

Canada 1 China 241 China Hong Kong 1 Europe 2 France 2 India 24 Italy 2 South Korea 2 United Kingdom 3 United States 27 Global 305

Hefei NaNo Biological Technology Co., Ltd.

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Jiangsu Yew Pharmaceutical Co., Ltd.

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Guangzhou Tomums Life Science Co., Ltd.

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Fujian South Pharmaceutical Co., Ltd.

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Taizhou Creating Bio-pharm Co.,Ltd.

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Jinan Good Medical &Technology Ltd Co.,

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Shanghai Boyle Chemical Co., Ltd.

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Chembest Research Laboratories Limited

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Jia Xing Isenchem Co.,Ltd

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Shanghai Longsheng chemical Co.,Ltd.

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View Lastest Price from Docetaxel trihydrate manufacturers

Fuzhou Lista Biotechnology Co.,Ltd

Product: Docetaxel·Trihydrate 148408-66-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99.99%
Supply Ability: 2000kgs
Release date: 2025-06-13

Wuhan JiyunZen Tech Co., Ltd.

Product: Docetaxel trihydrate 148408-66-6
Price: US $5.00-0.50/KG
Min. Order: 0.10000000149011612KG
Purity: 99% hplc
Supply Ability: 5000kg
Release date: 2025-06-06

Shaanxi Xianhe Biotech Co., Ltd

Product: Docetaxel Trihydrate 148408-66-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 0.99
Supply Ability: 1000KG
Release date: 2025-04-17

148408-66-6, Docetaxel trihydrateRelated Search:

(2R,3S)-Boc-3-Phenylisoserine Methyl (2R,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-3-phenylpropionate Docetaxel 7,11-methano-5h-cyclodeca[3,4]benz[1,2-b]oxete benzenepropanoic acid deriv. Docetaxel (3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetidinone 10-Oxo Docetaxel Docetaxel Metabolite M4 TYRPHOSTIN AG 1024 AVP-AEW541 NOCODAZOLE (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol Crizotinib Olaparib 13-O-(Triethylsilyl) Baccatin III 2-Debenzoyl-2-pentenoyl Docetaxel Docetaxel Impurity 5 Docetaxel Impurity 15

(αR,βS)-β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-benzenepropanoic acid, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-

Docetaxel/Docetaxel Trihydrate

Docetaxel (200 mg)

Taxotere Trihydrate

(αR,βS)-β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-benzenepropanoic acid, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester,hydrate (1:3)

RP56976 (NSC 628503) Trihydrate

Docetaxel(trihydrous)

(2AR,4S,4aS,6R,9S,11S,12S,12aS,12bS)-12b-acetoxy-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-

DOCETAXEL HYDRATE

Benzenepropanoic acid, beta-(((1,1-dimethylethoxy)carbonyl)amino)-alpha-hydroxy-, (2ar,4S,4as,6R,9S,11S,12S,12ar,12bs)-12B-(acetyloxy)-12-(benzoyloxy)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-dodecahydro-4,6,11-trihydroxy-4A,8,1313-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-B)oxet-9-yl ester, trihydrate, (alphar,betas)-

Unii-15H5577cqd

Xrp6976

7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.

Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyc

Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester trihydrate, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-

Docetaxel trihydrate

Docetaxel for system suitability CRS

Docetaxel trihydrate CRS

RP-56976 (Trihydrate)

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9-((3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate trihydrate

Docetaxel Trihydrate DISCONTINUED PLEASE SEE D494420

Docetaxel Trihydrate (RP 56976)

Docetaxel for system suitability (Y0001155)

Docetaxel TrihydrateQ: What is Docetaxel Trihydrate Q: What is the CAS Number of Docetaxel Trihydrate Q: What is the storage condition of Docetaxel Trihydrate Q: What are the applications of Docetaxel Trihydrate

Docetaxel (1224551)

Taxespira

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca3,4benzo1,2-boxet-12-yl benzoate trihydrate

Docetaxel Tryhydrate

Docetaxel (200 mg) ((2R,3S)-N-Carboxy-3-phenylisoserine, N-tert-butyl ester, 13-ester with 5Beta,20-epoxy-1,2alpha,4,7Beta,10Beta,13alpha-hexahydroxytax-11-en-9-one 4-acetate 2-benzoate trihydrate)

Docetaxel trihydrate, 10 mM in DMSO

Docetaxel trihydrate - Bio-X ?

148408-66-6

14848-66-6

C43H59NO17

C43H53NO143H2O

C43H59NO7

Anticancer

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Herb extract

TAXOTERE

Anti-cancer&immunity

Plant extract

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