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ETHYL 2-CHLORO-4-METHYLPYRIMIDINE-5-CARBOXYLATE

Product Name
ETHYL 2-CHLORO-4-METHYLPYRIMIDINE-5-CARBOXYLATE
CAS No.
188781-08-0
Chemical Name
ETHYL 2-CHLORO-4-METHYLPYRIMIDINE-5-CARBOXYLATE
Synonyms
2-Chloro-5-(ethoxycarbonyl)-4-methylpyrimidine;ETHYL 2-CHLORO-4-METHYLPYRIMIDINE-5-CARBOXYLATE;Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate ,97%;2-Chloro-4-methyl-5-pyrimidinecarboxylic acid ethyl ester;5-Pyrimidinecarboxylic acid, 2-chloro-4-methyl-, ethyl ester;2-chloro-4-methyl-5-Pyrimidinecarboxylic acid ethyl ester (9CI ACI);5-Pyrimidinecarboxylic acid, 2-chloro-4-methyl-, ethyl ester (9CI, ACI);2-Chloro-5-(ethoxycarbonyl)-4-methylpyrimidine, 2-Chloro-5-(ethoxycarbonyl)-4-methyl-1,3-diazine
CBNumber
CB3523447
Molecular Formula
C8H9ClN2O2
Formula Weight
200.62
MOL File
Mol file
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ETHYL 2-CHLORO-4-METHYLPYRIMIDINE-5-CARBOXYLATE Property

Boiling point:
302.7±22.0 °C(Predicted)
Density 
1.265
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
solid
pka
-2.56±0.29(Predicted)
color 
white
Water Solubility 
Slightly soluble in water.
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Usbiological
Product number
296121
Product name
Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate
Packaging
50mg
Price
$359
Updated
2021/12/16
Biosynth Carbosynth
Product number
NE57420
Product name
Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate
Packaging
100mg
Price
$126
Updated
2021/12/16
Biosynth Carbosynth
Product number
NE57420
Product name
Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate
Packaging
500mg
Price
$315
Updated
2021/12/16
Biosynth Carbosynth
Product number
NE57420
Product name
Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate
Packaging
1g
Price
$506
Updated
2021/12/16
Biosynth Carbosynth
Product number
NE57420
Product name
Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate
Packaging
250mg
Price
$157.5
Updated
2021/12/16
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ETHYL 2-CHLORO-4-METHYLPYRIMIDINE-5-CARBOXYLATE Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

It is an active pharmaceutical intermediates.

Synthesis

6214-64-8

188781-08-0

The general procedure for the synthesis of ethyl 4-methyl-2-chloropyrimidine-5-carboxylate from ethyl 4-methyl-2-hydroxypyrimidine-5-carboxylate was as follows: ethyl 4-methyl-2-hydroxypyrimidine-5-carboxylate (10 mmol) was dissolved in phosphorochloride (10 mL), and heated and refluxed for 30 min. Upon completion of the reaction, the excess phosphorus trichloride was removed by distillation under reduced pressure. Subsequently, residual phosphorous trichloride was removed by azeotropic distillation with dried benzene. Finally, the crude product was purified by column chromatography to afford pure ethyl 4-methyl-2-chloropyrimidine-5-carboxylate.

References

[1] European Journal of Medicinal Chemistry, 2011, vol. 46, # 6, p. 2290 - 2294
[2] Patent: WO2016/37578, 2016, A1. Location in patent: Page/Page column 70
[3] European Journal of Medicinal Chemistry, 2013, vol. 66, p. 314 - 323

ETHYL 2-CHLORO-4-METHYLPYRIMIDINE-5-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Ethanol Triethyl orthoformate Sodium Phosphorus oxitrichloride Chloroform Urea

Preparation Products

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ETHYL 2-CHLORO-4-METHYLPYRIMIDINE-5-CARBOXYLATE Suppliers

China 93 India 1 United Kingdom 2 United States 14 Global 110
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
Apollo Scientific Ltd.
Tel
--
Fax
--
Email
sales@apolloscientific.co.uk
Country
United Kingdom
ProdList
6084
Advantage
88
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View Lastest Price from ETHYL 2-CHLORO-4-METHYLPYRIMIDINE-5-CARBOXYLATE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate 188781-08-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-15
Career Henan Chemical Co
Product
ETHYL 2-CHLORO-4-METHYLPYRIMIDINE-5-CARBOXYLATE 188781-08-0
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
200kg
Release date
2018-12-24

188781-08-0, ETHYL 2-CHLORO-4-METHYLPYRIMIDINE-5-CARBOXYLATERelated Search:

Ethyl (triphenylphosphoranylidene)acetate 3-(4-BROMO-PHENYL)-PROPIONIC ACID ETHYL ESTER ETHYL-D5 CARBAMATE Ectoine 4-Hydroxy-2-(trifluoromethyl)pyrimidine 4-methyl-2-hydroxy-pyrimidine-5-carboxylic acid ETHYL 2-CHLORO-4-PHENYLPYRIMIDINE-5-CARBOXYLATE ETHYL 2-HYDROXY-4-PHENYLPYRIMIDINE-5-CARBOXYLATE Ethyl 2-hydroxy-4-methyl-5-pyrimidinecarboxylate 2-Chloropyrimidine-5-carboxylic acid 2-Chloro-4-methylpyrimidine

  • ETHYL 2-CHLORO-4-METHYLPYRIMIDINE-5-CARBOXYLATE
  • 2-Chloro-5-(ethoxycarbonyl)-4-methylpyrimidine
  • 2-Chloro-4-methyl-5-pyrimidinecarboxylic acid ethyl ester
  • Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate ,97%
  • 2-Chloro-5-(ethoxycarbonyl)-4-methylpyrimidine, 2-Chloro-5-(ethoxycarbonyl)-4-methyl-1,3-diazine
  • 5-Pyrimidinecarboxylic acid, 2-chloro-4-methyl-, ethyl ester
  • 5-Pyrimidinecarboxylic acid, 2-chloro-4-methyl-, ethyl ester (9CI, ACI)
  • 2-chloro-4-methyl-5-Pyrimidinecarboxylic acid ethyl ester (9CI ACI)
  • 188781-08-0
  • pyrimidine
  • Heterocycle-Pyrimidine series