ETHYL 2-CHLORO-4-METHYLPYRIMIDINE-5-CARBOXYLATE

Product Name: ETHYL 2-CHLORO-4-METHYLPYRIMIDINE-5-CARBOXYLATE
CAS No.: 188781-08-0
Chemical Name: ETHYL 2-CHLORO-4-METHYLPYRIMIDINE-5-CARBOXYLATE
Synonyms: 2-Chloro-5-(ethoxycarbonyl)-4-methylpyrimidine;ETHYL 2-CHLORO-4-METHYLPYRIMIDINE-5-CARBOXYLATE;Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate ,97%;2-Chloro-4-methyl-5-pyrimidinecarboxylic acid ethyl ester;5-Pyrimidinecarboxylic acid, 2-chloro-4-methyl-, ethyl ester;2-chloro-4-methyl-5-Pyrimidinecarboxylic acid ethyl ester (9CI ACI);5-Pyrimidinecarboxylic acid, 2-chloro-4-methyl-, ethyl ester (9CI, ACI);2-Chloro-5-(ethoxycarbonyl)-4-methylpyrimidine, 2-Chloro-5-(ethoxycarbonyl)-4-methyl-1,3-diazine
CBNumber: CB3523447
Molecular Formula: C8H9ClN2O2
Formula Weight: 200.62
MOL File: Mol file

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ETHYL 2-CHLORO-4-METHYLPYRIMIDINE-5-CARBOXYLATE Property

Boiling point:: 302.7±22.0 °C(Predicted)
Density: 1.265
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
pka: -2.56±0.29(Predicted)
color: white
Water Solubility: Slightly soluble in water.

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Usbiological

Product number: 296121
Product name: Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate
Packaging: 50mg
Price: $359
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NE57420
Product name: Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate
Packaging: 100mg
Price: $126
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NE57420
Product name: Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate
Packaging: 500mg
Price: $315
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NE57420
Product name: Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate
Packaging: 1g
Price: $506
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NE57420
Product name: Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate
Packaging: 250mg
Price: $157.5
Updated: 2021/12/16

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ETHYL 2-CHLORO-4-METHYLPYRIMIDINE-5-CARBOXYLATE Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

It is an active pharmaceutical intermediates.

Synthesis

6214-64-8

188781-08-0

The general procedure for the synthesis of ethyl 4-methyl-2-chloropyrimidine-5-carboxylate from ethyl 4-methyl-2-hydroxypyrimidine-5-carboxylate was as follows: ethyl 4-methyl-2-hydroxypyrimidine-5-carboxylate (10 mmol) was dissolved in phosphorochloride (10 mL), and heated and refluxed for 30 min. Upon completion of the reaction, the excess phosphorus trichloride was removed by distillation under reduced pressure. Subsequently, residual phosphorous trichloride was removed by azeotropic distillation with dried benzene. Finally, the crude product was purified by column chromatography to afford pure ethyl 4-methyl-2-chloropyrimidine-5-carboxylate.

References

[1] European Journal of Medicinal Chemistry, 2011, vol. 46, # 6, p. 2290 - 2294
[2] Patent: WO2016/37578, 2016, A1. Location in patent: Page/Page column 70
[3] European Journal of Medicinal Chemistry, 2013, vol. 66, p. 314 - 323

ETHYL 2-CHLORO-4-METHYLPYRIMIDINE-5-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Ethanol Triethyl orthoformate Sodium Phosphorus oxitrichloride Chloroform Urea

Preparation Products

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ETHYL 2-CHLORO-4-METHYLPYRIMIDINE-5-CARBOXYLATE Suppliers

China 93 India 1 United Kingdom 2 United States 14 Global 110

Pure Chemistry Scientific Inc.

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View Lastest Price from ETHYL 2-CHLORO-4-METHYLPYRIMIDINE-5-CARBOXYLATE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate 188781-08-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-15

Career Henan Chemical Co

Product: ETHYL 2-CHLORO-4-METHYLPYRIMIDINE-5-CARBOXYLATE 188781-08-0
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 200kg
Release date: 2018-12-24

188781-08-0, ETHYL 2-CHLORO-4-METHYLPYRIMIDINE-5-CARBOXYLATERelated Search:

Ethyl (triphenylphosphoranylidene)acetate 3-(4-BROMO-PHENYL)-PROPIONIC ACID ETHYL ESTER ETHYL-D5 CARBAMATE Ectoine 4-Hydroxy-2-(trifluoromethyl)pyrimidine 4-methyl-2-hydroxy-pyrimidine-5-carboxylic acid ETHYL 2-CHLORO-4-PHENYLPYRIMIDINE-5-CARBOXYLATE ETHYL 2-HYDROXY-4-PHENYLPYRIMIDINE-5-CARBOXYLATE Ethyl 2-hydroxy-4-methyl-5-pyrimidinecarboxylate 2-Chloropyrimidine-5-carboxylic acid 2-Chloro-4-methylpyrimidine

ETHYL 2-CHLORO-4-METHYLPYRIMIDINE-5-CARBOXYLATE

2-Chloro-5-(ethoxycarbonyl)-4-methylpyrimidine

2-Chloro-4-methyl-5-pyrimidinecarboxylic acid ethyl ester

Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate ,97%

2-Chloro-5-(ethoxycarbonyl)-4-methylpyrimidine, 2-Chloro-5-(ethoxycarbonyl)-4-methyl-1,3-diazine

5-Pyrimidinecarboxylic acid, 2-chloro-4-methyl-, ethyl ester

5-Pyrimidinecarboxylic acid, 2-chloro-4-methyl-, ethyl ester (9CI, ACI)

2-chloro-4-methyl-5-Pyrimidinecarboxylic acid ethyl ester (9CI ACI)

188781-08-0

pyrimidine

Heterocycle-Pyrimidine series