TCO4-PEG3-NHS

Product Name: TCO4-PEG3-NHS
CAS No.: 2141981-88-4
Chemical Name: TCO4-PEG3-NHS
Synonyms: TCO4-PEG3-NHS;2,5-Dioxopyrrolidin-1-yl (E)-1-(cyclooct-4-en-1-yloxy)-1-oxo-5,8,11-trioxa-2-azatetradecan-14-oate;2,5-dioxopyrrolidin-1-yl (Z)-1-(cyclooct-4-en-1-yloxy)-1-oxo-5,8,11-trioxa-2-azatetradecan-14-oate;5,8,11-Trioxa-2-azatetradecanedioic acid, 1-(4-cycloocten-1-yl) 14-(2,5-dioxo-1-pyrrolidinyl) ester
CBNumber: CB35857163
Molecular Formula: C22H34N2O9
Formula Weight: 470.51
MOL File: 2141981-88-4.mol

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TCO4-PEG3-NHS Property

Density: 1.24±0.1 g/cm3(Predicted)
solubility: Soluble in DMSO, DCM, DMF
pka: 11.95±0.46(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-24147
Product name: TCO-PEG3-NHSester
Purity: 95%
Packaging: 25mg
Price: $180
Updated: 2021/12/16

BroadPharm

Product number: BP-24147
Product name: TCO-PEG3-NHSester
Purity: 95%
Packaging: 100mg
Price: $490
Updated: 2021/12/16

BroadPharm

Product number: BP-24147
Product name: TCO-PEG3-NHSester
Purity: 95%
Packaging: 250mg
Price: $980
Updated: 2021/12/16

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TCO4-PEG3-NHS Chemical Properties,Usage,Production

Description

TCO-PEG3-NHS Ester is a PEG linker containing a TCO moiety and a NHS ester. The hydrophilic PEG spacer increases water-solubility and a decreases steric hindrance during ligation. This reagent can be used to label antibodies, proteins and other primary amine-containing macromolecules with TCO moiety.

Uses

TCO-PEG3-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238. DOI:10.1016/j.apsb.2019.08.001

TCO4-PEG3-NHS Preparation Products And Raw materials

Raw materials

Preparation Products

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TCO4-PEG3-NHS Suppliers

China 21 United States 2 Global 23

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2141981-88-4, TCO4-PEG3-NHSRelated Search:

TCO4-PEG8-NHS TCO4-PEG8-COOH TCO4-PEG2-Maleimide (4E)-TCO-PEG3-amine TCO4-PEG3-Maleimide TCO-PEG4-Acid TCO4-PEG7-NH2 TCO-PEG3-acid TCO4-PEG7-Maleimide TCO4-PEG2-NH2 TCO-PEG4-NHS Ester

TCO4-PEG3-NHS

5,8,11-Trioxa-2-azatetradecanedioic acid, 1-(4-cycloocten-1-yl) 14-(2,5-dioxo-1-pyrrolidinyl) ester

2,5-dioxopyrrolidin-1-yl (Z)-1-(cyclooct-4-en-1-yloxy)-1-oxo-5,8,11-trioxa-2-azatetradecan-14-oate

2,5-Dioxopyrrolidin-1-yl (E)-1-(cyclooct-4-en-1-yloxy)-1-oxo-5,8,11-trioxa-2-azatetradecan-14-oate

2141981-88-4

C22H34N2O9

SiChem