JAK INHIBITOR I

Product Name: JAK INHIBITOR I
CAS No.: 457081-03-7
Chemical Name: JAK INHIBITOR I
Synonyms: Pyridone 6;7H-Benz[h]imidazo[4,5-f]isoquinolin-7-one, 2-(1,1-dimethylethyl)-9-fluoro-1,6-dihydro-;CMP 6;CS-665;MERk-5;Merck-5;JAK Inhibitor;MERCK 5;MERCK5;JAK INHIBITOR I;Pyridone 6, >=98%
CBNumber: CB3670758
Molecular Formula: C18H16FN3O
Formula Weight: 309.34
MOL File: Mol file

More

Less

JAK INHIBITOR I Property

Melting point:: >178°C (dec.)
Boiling point:: 646.5±55.0 °C(Predicted)
Density: 1.328
storage temp.: -20C
solubility: Soluble in DMSO (30 mg/ml)
form: Off-white solid
pka: 11.35±0.20(Predicted)
color: Off-white
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 420099
Product name: JAK Inhibitor I - CAS 457081-03-7 - Calbiochem
Purity: JAK Inhibitor I, CAS 457081-03-7, is a potent, reversible, cell-permeable, and ATP-competitive inhibitor of JAK 1 (IC?? = 15 nM), JAK2 (IC?? = 1 nM), JAK3 (Ki = 5 nM) and Tyk2 (IC?? = 1 nM).
Packaging: 500μg
Price: $187
Updated: 2024/03/01

Sigma-Aldrich

Product number: 420099
Product name: JAK Inhibitor I - CAS 457081-03-7 - Calbiochem<br />JAK Inhibitor I, CAS 457081-03-7, is a potent, reversible, cell-permeable, and ATP-competitive inhibitor of JAK 1 (IC = 15 nM), JAK2 (IC = 1 nM), JAK3 (Ki = 5 nM) and Tyk2 (IC = 1 nM).
Packaging: 1mg
Price: $245
Updated: 2024/03/01

Sigma-Aldrich

Product number: 420097
Product name: InSolutionJAKInhibitorI-CAS457081-03-7-Calbiochem
Purity: TheInSolutionJAKInhibitorI,alsoreferencedunderCAS457081-03-7,controls
Packaging: 500μg
Price: $159
Updated: 2024/03/01

Cayman Chemical

Product number: 15146
Product name: JAK Inhibitor I
Purity: ≥98%
Packaging: 1mg
Price: $29
Updated: 2024/03/01

Cayman Chemical

Product number: 15146
Product name: JAK Inhibitor I
Purity: ≥98%
Packaging: 500μg
Price: $70
Updated: 2023/06/20

More

Less

JAK INHIBITOR I Chemical Properties,Usage,Production

Description

Pyridone 6 (457081-03-7) is a potent, ATP-competitive pan-JAK inhibitor. Inhibits 1, 2 and 3 (IC50=1, 5 and 15 nM respectively) as well as JAK family member Tyk2 (IC50=1 nM).1 Also tested against 21 other kinases with inhibition ranging from 130 nm to >10 mM. Inhibits IL2 and IL4-dependent proliferation of CTLL cells.1 Induces intermediate mesoderm differentiation from embryonic stem cells in a cocktail with LY-294002, CCG-1423 and retinoic acid.2 Potently inhibits STAT1, STAT5 and STAT6 phosphorylation and ameliorates allergic skin inflammation in a mouse model.3 Suppresses asthmatic responses in a mouse allergic asthma model.4

Uses

Pyridone 6 is a ATP-competitive JAK inhibitor in clinical development for the treatment of myeloproliferative neoplasms and B cell acute lymphoblastic leukemia.

Definition

ChEBI: 2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one is an organic heterotetracyclic compound that is 1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one bearing additional tert-butyl and fluoro substituents at positions 2 and 9 respectively. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is an organic heterotetracyclic compound and an organofluorine compound.

storage

Store at -20°C

References

Thompson et al. (2002) Photochemical preparation of a pyridine containing tetracycle: a JAK protein kinase inhibitor Med. Chem. Lett. 12 1219 Mae et al. (2010) Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells; Biochem. Biophys. Res. Commun. 393 877 Nakagawa et al. (2011) Pyridone 6, a pan-JAK inhibitor, ameliorates allergic skin inflammation of NC/Nga mice via suppression of Th2 and enhancement of Th17; Immunol. 187 4611 Moriwaki et al. (2011) IL-13 suppresses double-stranded RNA-induced IFN-l production in lung cells; Biochem. Biophys. Res. Commun. 404 922

JAK INHIBITOR I Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

JAK INHIBITOR I Suppliers

Canada 1 China 88 India 1 United Kingdom 2 United States 22 Global 114

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2923
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6011
Advantage: 61

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 17987
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

Xi’an chemsoar Medical Technology Co., ltd

Tel: 029-86538357
Fax: 029-87871708
Country: China
ProdList: 234
Advantage: 57

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1494
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

SYN|thesis med chem P/L

Tel: +86-021-50720296
Fax: +86-021-50720297
Email: service@synkinase.com
Country: China
ProdList: 266
Advantage: 58

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
Advantage: 58

More

Less

View Lastest Price from JAK INHIBITOR I manufacturers

Career Henan Chemical Co

Product: Pyridone 6 457081-03-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2019-12-30

457081-03-7, JAK INHIBITOR IRelated Search:

KU57788(NU7441) Elafibranor(GFT505) N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1) NORFLUOXETINE HYDROCHLORIDE Zinc pyrithione

Merck-5

MERk-5

2-(tert-butyl)-9-fluoro-3H-benzo[h]iMidazo[4,5-f]isoquinolin-7(6H)-one

Pyridone 6（JAK INHIBITOR I）

JAK Inhibitor I - CAS 457081-03-7 - Calbiochem

JAK Inhibitor I(Merck 5)

MERCK 5;MERCK5

CS-665

CMP 6

2-(1,1-Dimethylethyl)-9-fluoro-1,6-dihydro-7H-benz[h]imidazo[4,5-f]isoquinolin-7-one

Pyridone 6, >=98%

2-(1,1-DIMETHYLETHYL)-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F] ISOQUINOLIN-7-ONE

JAK INHIBITOR I

Merck-5 ,JAK INHIBITOR I

JAK Inhibitor

Pyridone 6

CMP 6 2-(1,1-Dimethylethyl)-9-fluoro-1,6-dihydro-7H-benz[h]imidazo[4,5-f]isoquinolin-7-one

Pyridone 6(CMP 6)

InSolution(TM) JAK Inhibitor I

Janus-Associated Kinase Inhibitor I

7H-Benz[h]imidazo[4,5-f]isoquinolin-7-one, 2-(1,1-dimethylethyl)-9-fluoro-1,6-dihydro-

JAK Inhibitor I(Merck 5, Pyridone 6)

InSolution JAK Inhibitor I

2-(tert-butyl)-9-fluoro-1,6-dihydro-7H-benzo[h]imidazo[4,5-f]isoquinolin-7-one

9-Fluoro-2-(2-methyl-2-propanyl)-1,6-dihydro-7H-benzo[h]imid...

4-tert-butyl-15-fluoro-3,5,10-triazatetracyclo[11.4.0.02,?.0?,12]heptadeca-1(13),2(6),4,7(12),8,14,16-heptaen-11-one

2-(tert-butyl)-9-fluoro-1H-benzo[h]imidazo[4,5-f]isoquinolin-7(6H)-one

457081-03-7

457091-03-7

Inhibitors