JAK INHIBITOR I
- Product Name
- JAK INHIBITOR I
- CAS No.
- 457081-03-7
- Chemical Name
- JAK INHIBITOR I
- Synonyms
- Pyridone 6;7H-Benz[h]imidazo[4,5-f]isoquinolin-7-one, 2-(1,1-dimethylethyl)-9-fluoro-1,6-dihydro-;CMP 6;CS-665;MERk-5;Merck-5;JAK Inhibitor;MERCK 5;MERCK5;JAK INHIBITOR I;Pyridone 6, >=98%
- CBNumber
- CB3670758
- Molecular Formula
- C18H16FN3O
- Formula Weight
- 309.34
- MOL File
- Mol file
JAK INHIBITOR I Property
- Melting point:
- >178°C (dec.)
- Boiling point:
- 646.5±55.0 °C(Predicted)
- Density
- 1.328
- storage temp.
- -20C
- solubility
- Soluble in DMSO (30 mg/ml)
- form
- Off-white solid
- pka
- 11.35±0.20(Predicted)
- color
- Off-white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 420099
- Product name
- JAK Inhibitor I - CAS 457081-03-7 - Calbiochem
- Purity
- JAK Inhibitor I, CAS 457081-03-7, is a potent, reversible, cell-permeable, and ATP-competitive inhibitor of JAK 1 (IC?? = 15 nM), JAK2 (IC?? = 1 nM), JAK3 (Ki = 5 nM) and Tyk2 (IC?? = 1 nM).
- Packaging
- 500μg
- Price
- $187
- Updated
- 2024/03/01
- Product number
- 420099
- Product name
- JAK Inhibitor I - CAS 457081-03-7 - Calbiochem<br />JAK Inhibitor I, CAS 457081-03-7, is a potent, reversible, cell-permeable, and ATP-competitive inhibitor of JAK 1 (IC = 15 nM), JAK2 (IC = 1 nM), JAK3 (Ki = 5 nM) and Tyk2 (IC = 1 nM).
- Packaging
- 1mg
- Price
- $245
- Updated
- 2024/03/01
- Product number
- 420097
- Product name
- InSolutionJAKInhibitorI-CAS457081-03-7-Calbiochem
- Purity
- TheInSolutionJAKInhibitorI,alsoreferencedunderCAS457081-03-7,controls
- Packaging
- 500μg
- Price
- $159
- Updated
- 2024/03/01
- Product number
- 15146
- Product name
- JAK Inhibitor I
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $29
- Updated
- 2024/03/01
- Product number
- 15146
- Product name
- JAK Inhibitor I
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $70
- Updated
- 2023/06/20
JAK INHIBITOR I Chemical Properties,Usage,Production
Description
Pyridone 6 (457081-03-7) is a potent, ATP-competitive pan-JAK inhibitor. Inhibits 1, 2 and 3 (IC50=1, 5 and 15 nM respectively) as well as JAK family member Tyk2 (IC50=1 nM).1 Also tested against 21 other kinases with inhibition ranging from 130 nm to >10 mM. Inhibits IL2 and IL4-dependent proliferation of CTLL cells.1 Induces intermediate mesoderm differentiation from embryonic stem cells in a cocktail with LY-294002, CCG-1423 and retinoic acid.2 Potently inhibits STAT1, STAT5 and STAT6 phosphorylation and ameliorates allergic skin inflammation in a mouse model.3 Suppresses asthmatic responses in a mouse allergic asthma model.4
Uses
Pyridone 6 is a ATP-competitive JAK inhibitor in clinical development for the treatment of myeloproliferative neoplasms and B cell acute lymphoblastic leukemia.
Definition
ChEBI: 2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one is an organic heterotetracyclic compound that is 1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one bearing additional tert-butyl and fluoro substituents at positions 2 and 9 respectively. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is an organic heterotetracyclic compound and an organofluorine compound.
storage
Store at -20°C
References
Thompson et al. (2002) Photochemical preparation of a pyridine containing tetracycle: a JAK protein kinase inhibitor Med. Chem. Lett. 12 1219 Mae et al. (2010) Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells; Biochem. Biophys. Res. Commun. 393 877 Nakagawa et al. (2011) Pyridone 6, a pan-JAK inhibitor, ameliorates allergic skin inflammation of NC/Nga mice via suppression of Th2 and enhancement of Th17; Immunol. 187 4611 Moriwaki et al. (2011) IL-13 suppresses double-stranded RNA-induced IFN-l production in lung cells; Biochem. Biophys. Res. Commun. 404 922
JAK INHIBITOR I Preparation Products And Raw materials
Raw materials
Preparation Products
JAK INHIBITOR I Suppliers
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View Lastest Price from JAK INHIBITOR I manufacturers
- Product
- Pyridone 6 457081-03-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-30