Background and overview Pharmacological effects Pharmacokinetics Indications Adverse reactions Medicine interactions Precautions Contraindication Elderly patients medication
ChemicalBook > CAS DataBase List > Ranitidine Hydrochloride

Ranitidine Hydrochloride

Background and overview Pharmacological effects Pharmacokinetics Indications Adverse reactions Medicine interactions Precautions Contraindication Elderly patients medication
Product Name
Ranitidine Hydrochloride
CAS No.
66357-59-3
Chemical Name
Ranitidine Hydrochloride
Synonyms
Zamec;ZANTAC;Melfax;Zintac;noctone;ranidil;ah19065;NoCLone;Azantac;Raniben
CBNumber
CB3685534
Molecular Formula
C13H23ClN4O3S
Formula Weight
350.86
MOL File
66357-59-3.mol
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Ranitidine Hydrochloride Property

Melting point:
134°C (dec.)
storage temp. 
2-8°C
solubility 
H2O: 1.8 mg/mL
form 
solid
color 
tan
Water Solubility 
Soluble in water, 2-hydroxypropyl-beta-cyclodextrin, acetic acid, methanol, ethanol and dimethyl sulfoxide. Insoluble in chloroform.
Sensitive 
Hygroscopic
Merck 
14,8110
BCS Class
3/1
Stability:
Hygroscopic
CAS DataBase Reference
66357-59-3(CAS DataBase Reference)
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Safety

Hazard Codes 
F,T
Risk Statements 
20/21/22-39/23/24/25-23/24/25-11
Safety Statements 
22-24/25-45-36/37-16-7
WGK Germany 
2
RTECS 
KM6557000
HS Code 
2932190002
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR1026
Product name
Ranitidine hydrochloride
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
500mg
Price
$117
Updated
2024/03/01
Sigma-Aldrich
Product number
1598405
Product name
Ranitidine hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$261.6
Updated
2024/03/01
Sigma-Aldrich
Product number
BP471
Product name
Ranitidine hydrochloride
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$231
Updated
2023/06/20
TCI Chemical
Product number
R0073
Product name
Ranitidine Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$70
Updated
2024/03/01
TCI Chemical
Product number
R0073
Product name
Ranitidine Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$181
Updated
2024/03/01
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Ranitidine Hydrochloride Chemical Properties,Usage,Production

Background and overview

Ranitidine Hydrochloride (RHCl) is a kind of histamine H2 receptor antagonist. Since its listing in 1981, ranitidine hydrochloride has been widely used in nearly one hundred countries in the world, including China. It is clinically used for the treatment of duodenal ulcer, reflux esophagitis and Zollinger-Ellison syndrome. It is also used for the prevention of gastrointestinal bleeding caused by stress ulcer and recurrent hemorrhage of peptic ulcer. In recent decade, through the combination of ranitidine and other drugs, it has found that it has high efficiency and remarkable features in the treatment of Helicobacter pylori-positive duodenal ulcer, urticaria and post-cerebral hemorrhage stress ulcer with better efficacy than other similar drugs. Owing to its rapid effect, good potency and low price, ranitidine hydrochloride plays an important role in the anti-ulcer drug market today. Therefore, strict quality control plays important roles in guiding patients with reasonable, safe medication.

Pharmacological effects

This product is a H2 receptor inhibitor, being capable of inhibiting the gastric acid secretion. After oral administration, it is absorbed through the gastrointestinal tract quickly. Synthetic route [4]
The intermediates (3) and (5) were synthesized as follows. The intermediates (3) and (5) were then reacted to produce (6) ranitidine. The (6) is subject to purification and salt formation to generate ranitidine hydrochloride, as shown:

Pharmacokinetics

After oral administration, it is absorbed rapidly from the gastrointestinal tract with a bioavailability (F) of about 50% and peak plasma concentration (tmax) reaching within 1 to 2 hours. Plasma protein binding rate is 15% ± 3%; effective blood concentration is 100ng / ml, widely distributed in the body with the apparent volume of distribution (Vd) of 1.1 ~ 1.9L / Kg. It can penetrate through the blood brain barrier with the drug concentration in cerebrospinal fluid being 1/30 ~ 1 / 20 of blood concentration. 30% is subject to liver metabolism with the metabolites including N-oxide, S-oxide and demethylation metabolites. 50% of the prototype is subject to urine excretion through kidney. Half-life (t1 / 2) is 2 to 3 hours, which is similar to cimetidine. Renal failure causes corresponding increase in the half-life. The goods can be transplanted via the placenta with the milk concentration being higher than the plasma concentration of drugs.

Indications

For the treatment of duodenal ulcer, gastric ulcer, reflux esophagitis, Zollinger-Ellison syndrome and other high acid secretion disorders.

Adverse reactions

  • Common reactions are: nausea, rash, constipation, fatigue, headache, dizziness and so on.
  • Light adverse reactions on the renal function, gonadal function and central nervous system.
  • A small number of patients get mild liver damage after taking the drug with the symptoms disappearing after stopping, liver function returned to normal.

Medicine interactions

  • Combination with procainamide reduces the clearance rate of the later one.
  • Drug interactions may occur if used with other medications, consult physician or pharmacist for details.

Precautions

  • This product mustn’t be used continuously for more than 7 days, the symptom is not relieved, consult your physician or pharmacist.
  • Elderly patients or patients with liver and kidney dysfunction use with caution.
  • If overdose or serious adverse reactions, should seek medical treatment immediately.
  • Disable it for people who are allergic to this product; allergies should use with caution.
  • This product is not allowed for administration upon change of its traits.
  • Please put this product where children cannot touch.
  • Children must be under adult guardianship. 
  • If you are using other drugs, please consult your physician or pharmacist before using this product.

Contraindication

  • Children under 8 years should be disabled.
  • Pregnant and lactating women should be disabled.

Elderly patients medication

The elderly have reduced liver and kidney function; in order to ensure drug safety, dosage should be adjusted.

Chemical Properties

Off-White Crystalline Solid

Uses

A histamine H2-receptor antagonist which inhibits gastric acid secretion. Antiulcerative.

Uses

antifungal

Uses

An H-2 histamine receptor antagonistRanitidine hydrochloride is mainly used as an H2-receptor antagonist and helps in the treatment of gastrointestinal lesions because of excessive gastric acid secretion. It also serves as an antiulcer drug.

brand name

Zantac (GlaxoSmithKline).

Biological Activity

ranitidine is a histamine h2-receptor antagonist that inhibits stomach acid production.ranitidine (zantac) is a histamine h2-receptor antagonist with ic50 of 3.3 ± 1.4 um. it inhibits stomach acid production. it is also used alongside fexofenadine and oth

Biochem/physiol Actions

H2 histamine receptor antagonist; anti-ulcer agent.

Contact allergens

Ranitidine, an H2-receptor antagonist, can cause contact dermatitis within the pharmaceutical industry and in health care workers, or may induce systemic drug reactions in patients.

storage

+4°C (desiccate)

Ranitidine Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Ranitidine Hydrochloride Suppliers

Australia 1 Austria 1 Belgium 2 Brazil 2 Canada 4 China 236 Czech Republic 1 Europe 2 France 1 Germany 8 Greece 1 India 71 Italy 3 Japan 3 Jordan 1 Malaysia 1 Mexico 1 Nigeria 1 Philippines 1 Poland 2 Russia 1 Singapore 1 Slovenia 1 South Africa 1 South Korea 3 Spain 3 Switzerland 4 The Netherlands 2 Ukraine 1 United Arab Emirates 1 United Kingdom 11 United States 53 Global 425
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View Lastest Price from Ranitidine Hydrochloride manufacturers

Hebei ZB Gamay Biological Technology Co.,Ltd
Product
Ranitidine 66357-59-3
Price
US $0.00-0.00/kg
Min. Order
25kg
Purity
98.00%
Supply Ability
1000kg
Release date
2022-12-22
airuikechemical co., ltd.
Product
Ranitidine hydrochloride 66357-59-3
Price
US $0.00-0.00/g
Min. Order
1g
Purity
99.9%
Supply Ability
20tons
Release date
2024-04-03
Hebei Chuanghai Biotechnology Co,.LTD
Product
Ranitidine Hydrochloride 66357-59-3
Price
US $10.50/KG
Min. Order
1KG
Purity
99%
Supply Ability
1 ton
Release date
2024-08-21

66357-59-3, Ranitidine HydrochlorideRelated Search:

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