4-(2-CHLORO-4-PYRIMIDINYL)MORPHOLINE
- Product Name
- 4-(2-CHLORO-4-PYRIMIDINYL)MORPHOLINE
- CAS No.
- 62968-37-0
- Chemical Name
- 4-(2-CHLORO-4-PYRIMIDINYL)MORPHOLINE
- Synonyms
- 4-(2-Chloropyrimidin-4-yl);2-Chloro-4-morpholine pyrimidine;4-(2-CHLORO-4-PYRIMIDINYL)MORPHOLINE;4-(2-CHLORO-PYRIMIDIN-4-YL)-MORPHOLINE;Morpholine, 4-(2-chloro-4-pyrimidinyl)-
- CBNumber
- CB3689411
- Molecular Formula
- C8H10ClN3O
- Formula Weight
- 199.64
- MOL File
- 62968-37-0.mol
4-(2-CHLORO-4-PYRIMIDINYL)MORPHOLINE Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C598203
- Product name
- 4-(2-Chloropyrimidin-4-yl)morpholine
- Packaging
- 500mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- FC140787
- Product name
- 4-(2-Chloropyrimidin-4-yl)morpholine
- Packaging
- 1g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- 083952
- Product name
- 4-(2-Chloropyrimidin-4-yl)morpholine
- Purity
- 97%
- Packaging
- 1g
- Price
- $341
- Updated
- 2021/12/16
- Product number
- FC140787
- Product name
- 4-(2-Chloropyrimidin-4-yl)morpholine
- Packaging
- 2g
- Price
- $425
- Updated
- 2021/12/16
- Product number
- HCH0128196
- Product name
- 2-CHLORO-4-MORPHOLINOPYRIMIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.04
- Updated
- 2021/12/16
4-(2-CHLORO-4-PYRIMIDINYL)MORPHOLINE Chemical Properties,Usage,Production
Synthesis
110-91-8
3934-20-1
62968-37-0
General procedure: 2,4-Dichloropyrimidine (1.0 g, 6.7 mmol) was suspended in ethanol (20 ml) under inert atmosphere, cooled to 0°C and stirred. To this suspension triethylamine (1.4 ml, 10.1 mmol) and morpholine (0.59 ml, 6.7 mmol) were added sequentially. The reaction mixture was stirred at 0°C for 3 hours. After completion of the reaction, the mixture was concentrated in vacuum, diluted with 1 M NaOH solution (20 ml) and extracted with ethyl acetate (3 x 20 ml). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated in vacuum to give a colorless solid. The crude product was recrystallized by ethyl acetate/hexane to give 2-chloro-4-morpholino pyrimidine (1.21 g, 90% yield) as a colorless solid, which did not require further purification.LC-MS (ESP) analysis showed m/z 200 [M+H]+ and retention time (R/T) = 3.26 min.
References
[1] Patent: US2006/199804, 2006, A1. Location in patent: Page/Page column 27
[2] Tetrahedron, 2015, vol. 71, # 29, p. 4859 - 4867
[3] Organic Letters, 2018, vol. 20, # 2, p. 473 - 476
[4] Patent: WO2017/58503, 2017, A1. Location in patent: Page/Page column 419-421
[5] European Journal of Medicinal Chemistry, 1991, vol. 26, # 7, p. 729 - 733
4-(2-CHLORO-4-PYRIMIDINYL)MORPHOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
4-(2-CHLORO-4-PYRIMIDINYL)MORPHOLINE Suppliers
- Tel
- --
- Fax
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- info@specs.net
- Country
- The Netherlands
- ProdList
- 6833
- Advantage
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View Lastest Price from 4-(2-CHLORO-4-PYRIMIDINYL)MORPHOLINE manufacturers
- Product
- 4-(2-chloropyrimidin-4-yl)morpholine 62968-37-0
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-11-13