Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate
- Product Name
- Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate
- CAS No.
- 887267-53-0
- Chemical Name
- Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate
- Synonyms
- Ethyl 3-(2,5-difluorophenyl);ETHYL 2,5-DIFLUOROBENZOYLACETATE;Ethyl 2,5-difluoro-β-oxobenzenepropanoate;ETHYL 3-(2,5-DIFLUOROPHENYL)-3-OXOPROPANOATE;Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate 95+%;Benzenepropanoic acid, 2,5-difluoro-β-oxo-, ethyl ester;3-(2,5-Difluoro-phenyl)-3-oxo-propionic acid ethyl ester;2-fluoro-3-(3-fluorophenyl)-3-oxopropanoic acid ethyl ester
- CBNumber
- CB3689431
- Molecular Formula
- C11H10F2O3
- Formula Weight
- 228.19
- MOL File
- 887267-53-0.mol
Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate Property
- Boiling point:
- 275.7±25.0 °C(Predicted)
- Density
- 1.251±0.06 g/cm3(Predicted)
- pka
- 10.28±0.50(Predicted)
Safety
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- E916705
- Product name
- Ethyl3-(2,5-Difluorophenyl)-3-oxopropanoate
- Packaging
- 500mg
- Price
- $285
- Updated
- 2021/12/16
- Product number
- 2629-3-30
- Product name
- Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $291
- Updated
- 2021/12/16
- Product number
- 2629-3-30
- Product name
- Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate
- Purity
- 97%
- Packaging
- 1g
- Price
- $795
- Updated
- 2021/12/16
- Product number
- HCH0007231
- Product name
- ETHYL 3-(2,5-DIFLUOROPHENYL)-3-OXOPROPANOATE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $909.56
- Updated
- 2021/12/16
- Product number
- 4567AC
- Product name
- Ethyl3-(2,5-difluorophenyl)-3-oxopropanoate
- Packaging
- 5g
- Price
- $1063
- Updated
- 2021/12/16
Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate Chemical Properties,Usage,Production
Uses
Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate is commonly utilized in organic synthesis as C-nucleophiles. One specific example is its reaction with the N-terminal electrophile CF3CHN2, resulting in the formation of CF3-heterocycles, namely ethyl 6-fluoro-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydrocinnoline-3-carboxylate[1].
References
[1] Arkhipov A, et al. Unexpected Reactivity of Trifluoromethyl Diazomethane (CF3CHN2): Electrophilicity of the Terminal N?Atom. Organic Letters, 2016; 18: 3406–3409.