2,4-Dichloropyrido[2,3-d]pyrimidine
- Product Name
- 2,4-Dichloropyrido[2,3-d]pyrimidine
- CAS No.
- 126728-20-9
- Chemical Name
- 2,4-Dichloropyrido[2,3-d]pyrimidine
- Synonyms
- 2,4-dichloropyrido[2,3-d]...;2,4-DICHLOROPYRIDO[2,3-D]PYRIMIDINE;Pyrido[2,3-d]pyrimidine,2,4-dichloro-;2,4-Dichloro-pyrido[2,3-d]pyrimidine2,4-Dichloro-pyrido[2,3-d]pyrimidine
- CBNumber
- CB3696084
- Molecular Formula
- C7H3Cl2N3
- Formula Weight
- 200.02
- MOL File
- 126728-20-9.mol
2,4-Dichloropyrido[2,3-d]pyrimidine Property
- Melting point:
- 157-158 °C (decomp)
- Density
- 1.573±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.38±0.30(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D435393
- Product name
- 2,4-Dichloropyrido[2,3-d]pyrimidine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- Y7342
- Product name
- 2,4-Dichloropyrido[2,3-d]pyrimidine
- Packaging
- 1g
- Price
- $77
- Updated
- 2021/12/16
- Product number
- FD31600
- Product name
- 2,4-Dichloropyrido [2,3-D] pyrimidine
- Packaging
- 1g
- Price
- $115
- Updated
- 2021/12/16
- Product number
- CS-W003411
- Product name
- 2,4-Dichloropyrido[2,3-d]pyrimidine
- Packaging
- 10g
- Price
- $343
- Updated
- 2021/12/16
- Product number
- FD31600
- Product name
- 2,4-Dichloropyrido [2,3-D] pyrimidine
- Packaging
- 5G
- Price
- $375
- Updated
- 2021/12/16
2,4-Dichloropyrido[2,3-d]pyrimidine Chemical Properties,Usage,Production
Reactivity Profile
Selective disubstitution of 2,4-dichloropyrido[2,3-d]pyrimidine with various nucleophiles was investigated by Lavecchia et al. Suzuki and Stille cross-coupling reactions on monosubstituted compound 4-tert-butylamino-2-chloro-pyrido[2,3-d]pyrimidine were performed in high yields. ,4-dichloropyrido[2,3-d]pyrimidine was easily substituted at position 4 with different nucleophiles. This position was more reactive than position 2, as in simple pyrimidinic systems. 2,4-dichloropyrido[2,3-d]pyrimidine 3 was prepared from 2-aminonicotinic acid 1 via 2,4-dihydroxypyrido[2,3-d]pyrimidine 2 following Robin and Hitchings method.
Synthesis
2,4-dichloropyrido[2,3-d]pyrimidine 3 was prepared from 2-aminonicotinic acid 1 via 2,4-dihydroxypyrido[2,3-d]pyrimidine 2 following Robin and Hitchings method[1].
References
[1] G. Lavecchia, G. Guillaumet, S. Berteina-Raboin. “Selective bifunctionalization of pyrido[2,3-d]pyrimidines in positions 2 and 4 by SNAr and palladium-catalyzed coupling reactions.” Tetrahedron Letters 46 35 (2005): Pages 5851-5855.
2,4-Dichloropyrido[2,3-d]pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-Dichloropyrido[2,3-d]pyrimidine manufacturers
- Product
- 2,4-Dichloropyrido[2,3-d]pyrimidine 126728-20-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-14
- Product
- 2,4-DICHLOROPYRIDO[2,3-D]PYRIMIDINE 126728-20-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 2,4-DICHLOROPYRIDO[2,3-D]PYRIMIDINE 126728-20-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09