ChemicalBook > CAS DataBase List > 2,4-Dichloropyrido[2,3-d]pyrimidine

2,4-Dichloropyrido[2,3-d]pyrimidine

Product Name
2,4-Dichloropyrido[2,3-d]pyrimidine
CAS No.
126728-20-9
Chemical Name
2,4-Dichloropyrido[2,3-d]pyrimidine
Synonyms
2,4-dichloropyrido[2,3-d]...;2,4-DICHLOROPYRIDO[2,3-D]PYRIMIDINE;Pyrido[2,3-d]pyrimidine,2,4-dichloro-;2,4-Dichloro-pyrido[2,3-d]pyrimidine2,4-Dichloro-pyrido[2,3-d]pyrimidine
CBNumber
CB3696084
Molecular Formula
C7H3Cl2N3
Formula Weight
200.02
MOL File
126728-20-9.mol
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2,4-Dichloropyrido[2,3-d]pyrimidine Property

Melting point:
157-158 °C (decomp)
Density 
1.573±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-0.38±0.30(Predicted)
Appearance
White to off-white Solid
InChI
InChI=1S/C7H3Cl2N3/c8-5-4-2-1-3-10-6(4)12-7(9)11-5/h1-3H
InChIKey
QSNSZGYDLUPWSV-UHFFFAOYSA-N
SMILES
C1(Cl)=NC(Cl)=C2C=CC=NC2=N1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
D435393
Product name
2,4-Dichloropyrido[2,3-d]pyrimidine
Packaging
50mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
Y7342
Product name
2,4-Dichloropyrido[2,3-d]pyrimidine
Packaging
1g
Price
$77
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD31600
Product name
2,4-Dichloropyrido [2,3-D] pyrimidine
Packaging
1g
Price
$115
Updated
2021/12/16
ChemScene
Product number
CS-W003411
Product name
2,4-Dichloropyrido[2,3-d]pyrimidine
Packaging
10g
Price
$343
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD31600
Product name
2,4-Dichloropyrido [2,3-D] pyrimidine
Packaging
5G
Price
$375
Updated
2021/12/16
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2,4-Dichloropyrido[2,3-d]pyrimidine Chemical Properties,Usage,Production

Reactivity Profile

Selective disubstitution of 2,4-dichloropyrido[2,3-d]pyrimidine with various nucleophiles was investigated by Lavecchia et al. Suzuki and Stille cross-coupling reactions on monosubstituted compound 4-tert-butylamino-2-chloro-pyrido[2,3-d]pyrimidine were performed in high yields. ,4-dichloropyrido[2,3-d]pyrimidine was easily substituted at position 4 with different nucleophiles. This position was more reactive than position 2, as in simple pyrimidinic systems. 2,4-dichloropyrido[2,3-d]pyrimidine 3 was prepared from 2-aminonicotinic acid 1 via 2,4-dihydroxypyrido[2,3-d]pyrimidine 2 following Robin and Hitchings method.

Synthesis

2,4-dichloropyrido[2,3-d]pyrimidine 3 was prepared from 2-aminonicotinic acid 1 via 2,4-dihydroxypyrido[2,3-d]pyrimidine 2 following Robin and Hitchings method[1].

References

[1] G. Lavecchia, G. Guillaumet, S. Berteina-Raboin. “Selective bifunctionalization of pyrido[2,3-d]pyrimidines in positions 2 and 4 by SNAr and palladium-catalyzed coupling reactions.” Tetrahedron Letters 46 35 (2005): Pages 5851-5855.

2,4-Dichloropyrido[2,3-d]pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,4-Dichloropyrido[2,3-d]pyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2,4-Dichloropyrido[2,3-d]pyrimidine 126728-20-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-14
Zhuozhou Wenxi import and Export Co., Ltd
Product
2,4-DICHLOROPYRIDO[2,3-D]PYRIMIDINE 126728-20-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
2,4-DICHLOROPYRIDO[2,3-D]PYRIMIDINE 126728-20-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

126728-20-9, 2,4-Dichloropyrido[2,3-d]pyrimidineRelated Search:

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  • 2,4-dichloropyrido[2,3-d]...
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  • 2,4-DICHLOROPYRIDO[2,3-D]PYRIMIDINE
  • 2,4-Dichloro-pyrido[2,3-d]pyrimidine2,4-Dichloro-pyrido[2,3-d]pyrimidine
  • 126728-20-9
  • C7H3Cl2N3