2,4-Dichloropyrido[3,4-d]pyrimidine

Product Name: 2,4-Dichloropyrido[3,4-d]pyrimidine
CAS No.: 908240-50-6
Chemical Name: 2,4-Dichloropyrido[3,4-d]pyrimidine
Synonyms: oropyrido[3,4-d]pyrimidine;2,4-dichioropyrido[3,4-d]pyrimidine;2,4-dichloropyrido[3,4-d]pyrimidine;Pyrido[3,4-d]pyrimidine, 2,4-dichloro-;2,4-Dichloropyrido[3,4-d]pyrimidine 96%;2,4-Dichloropyrido[3,4-d]pyrimidine ISO 9001：2015 REACH
CBNumber: CB61856091
Molecular Formula: C7H3Cl2N3
Formula Weight: 200.02
MOL File: 908240-50-6.mol

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2,4-Dichloropyrido[3,4-d]pyrimidine Property

Boiling point:: 302.4±24.0 °C(Predicted)
Density: 1.573
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 1.30±0.30(Predicted)
Appearance: Light yellow to yellow Solid
InChI: InChI=1S/C7H3Cl2N3/c8-6-4-1-2-10-3-5(4)11-7(9)12-6/h1-3H
InChIKey: YJUVYWACDUJBDG-UHFFFAOYSA-N
SMILES: C1(Cl)=NC(Cl)=C2C=CN=CC2=N1

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

TRC

Product number: D482540
Product name: 2,4-dichloropyrido[3,4-d]pyrimidine
Packaging: 2.5mg
Price: $45
Updated: 2021/12/16

TRC

Product number: D482540
Product name: 2,4-dichloropyrido[3,4-d]pyrimidine
Packaging: 5mg
Price: $60
Updated: 2021/12/16

TRC

Product number: D482540
Product name: 2,4-dichloropyrido[3,4-d]pyrimidine
Packaging: 25mg
Price: $175
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD148760
Product name: 2,4-Dichloropyrido[3,4-d]pyrimidine
Packaging: 25mg
Price: $112.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD148760
Product name: 2,4-Dichloropyrido[3,4-d]pyrimidine
Packaging: 50mg
Price: $170
Updated: 2021/12/16

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2,4-Dichloropyrido[3,4-d]pyrimidine Chemical Properties,Usage,Production

Synthesis

21038-67-5

908240-50-6

To a mixture of pyrido[3,4-d]pyrimidine-2,4(1H,3H)-dione (2b, 20.00 g, 122.60 mmol) and phosphorus oxychloride (POCl3, 328.03 g, 2.14 mol) in toluene (200 mL) was added dropwise N,N-diisopropylethylamine (DIEA, 31.69 g, 245.20 mmol ). The reaction mixture was stirred at 25 °C for 18 h to obtain a suspension. Upon completion of the reaction, the solvent and unreacted phosphorous trichloride were removed by distillation under reduced pressure. The residue was diluted with dichloromethane (DCM, 50 mL) and neutralized with DIEA to pH=7 at -20 °C. After concentration again, the residue was purified by silica gel column chromatography (eluent: 20-50% ethyl acetate/petroleum ether) to afford the target product 2,4-dichloropyrido[3,4-d]pyrimidine (2c, 20.00 g, 99.99 mmol, 82% yield) as a yellow solid. ), as a yellow solid. The product was confirmed by 1H NMR (400 MHz, CDCl3): δ 9.52 (s, 1H), 8.92 (d, J=5.6 Hz, 1H), 8.04 (d, J=5.6 Hz, 1H). the LCMS analysis showed m/z [M+H]+ of 200.0.

References

[1] Patent: WO2018/198077, 2018, A2. Location in patent: Page/Page column 189; 197; 225; 226; 262; 263
[2] Patent: WO2014/151106, 2014, A1. Location in patent: Paragraph 00109
[3] Patent: WO2016/44429, 2016, A1. Location in patent: Paragraph 00154; 00156

2,4-Dichloropyrido[3,4-d]pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-Dichloropyrido[3,4-d]pyrimidine Suppliers

China 103 India 1 United Kingdom 2 United States 14 Global 120

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View Lastest Price from 2,4-Dichloropyrido[3,4-d]pyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2,4-Dichloropyrido[3,4-d]pyrimidine 908240-50-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2019-12-27

Dideu Industries Group Limited

Product: 2,4-Dichloropyrido[3,4-d]pyrimidine 908240-50-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-03

Career Henan Chemical Co

Product: 2,4-Dichloropyrido[3,4-d]pyrimidine 908240-50-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-24

908240-50-6, 2,4-Dichloropyrido[3,4-d]pyrimidineRelated Search:

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2,4-Dichloropyrido[3,4-d]pyrimidine 96%

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2,4-Dichloropyrido[3,4-d]pyrimidine ISO 9001：2015 REACH

908240-50-6

CHIRAL CHEMICALS