ChemicalBook > CAS DataBase List > Tripeptide-1

Tripeptide-1

Product Name
Tripeptide-1
CAS No.
72957-37-0
Chemical Name
Tripeptide-1
Synonyms
GHK-HAC;Aldenine;Hilurlip;Prezatide;ArkTide N31;Liporeductyl;TRIPEPTIDE-1;GHK, Prezatide;Gly-His-Lys-OEt;Tripeptide-1/GHK
CBNumber
CB3702341
Molecular Formula
C16H28N6O6
Formula Weight
400.44
MOL File
72957-37-0.mol
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Tripeptide-1 Property

storage temp. 
-20°C
form 
powder
color 
white
Sequence
Gly-His-Lys
InChI
InChI=1/C14H24N6O4.C2H4O2/c15-4-2-1-3-10(14(23)24)20-13(22)11(19-12(21)6-16)5-9-7-17-8-18-9;1-2(3)4/h7-8,10-11H,1-6,15-16H2,(H,17,18)(H,19,21)(H,20,22)(H,23,24);1H3,(H,3,4)/t10-,11-;/s3
InChIKey
MGNUTAFMLGJBGV-ACMTZBLWSA-N
SMILES
C(=O)(O)C.[C@@H](NC(=O)CN)(C(=O)N[C@H](C(=O)O)CCCCN)CC1N=CNC=1 |&1:4,13,r|
CAS DataBase Reference
72957-37-0(CAS DataBase Reference)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
G7387
Product name
Gly-His-Lys acetate salt
Purity
BioXtra, γ-irradiated, suitable for cell culture
Packaging
0.5mg
Price
$184
Updated
2024/03/01
Sigma-Aldrich
Product number
G1887
Product name
Gly-His-Lys acetate salt
Purity
≥97% (TLC)
Packaging
10mg
Price
$210
Updated
2024/03/01
Sigma-Aldrich
Product number
G1887
Product name
Gly-His-Lys acetate salt
Purity
≥97% (TLC)
Packaging
50mg
Price
$791
Updated
2024/03/01
Alfa Aesar
Product number
J64138
Product name
Liver Cell Growth Factor acetate salt, BT-242
Packaging
1mg
Price
$39.2
Updated
2021/12/16
Usbiological
Product number
L3150-10
Product name
Liver Cell Growth Factor
Packaging
1mg
Price
$531
Updated
2021/12/16
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Tripeptide-1 Chemical Properties,Usage,Production

Description

Tripeptide-1 is a small peptide composed of three amino acids  (glycine-histidine-lysine or GHK) and is known for type I collagen fragments. When collagen fragment peptides (GHK) are added, it may mistakenly lead the skin to think that collagen has been broken down, resulting in more collagen. Therefore, tripeptide-1 is believed to stimulate collagen production in the skin. More collagen will reduce wrinkles on the face, which will improve the condition of the skin.

Chemical Properties

White powder

Uses

Liver Cell Growth Factor

Uses

Gly-His-Lys acetate salt has been used:

  • individually or as a complex with copper to test its effect on cytokines production in the human normal fibroblasts cell lines
  • as a model peptide in N,N-dimethyl-N-methacryloxyethyl-N-(3-sulfopropyl)ammonium betaine based capillary electrophoresis separation studies
  • as a component of Coon′s modified Ham′s F-12 medium for culturing Fischer rat thyroid follicular cell line, FRTL-5

General Description

Gly-His-Lys is a tripeptide present at ～200ng/ml in association with α-globulin and albumin, in human blood plasma.

Biochem/physiol Actions

Gly-His-Lys (GHK) acetate salt displays affinity towards copper(II) ions. This property enables GHK to modulate the copper intake into cells. GHK is also involved in quenching toxic by-products generated by lipid peroxidation.

in vitro

In an enzyme assay, the liver growth factor, Tripeptide-1, was hydrolyzed by an aminotripeptidase purified from rat brain cytosol[1].

in vivo

Tripeptide-1 (1% in saline; dose = 10 mg/kg) was injected into the tail vein of male rats (number not specified). Blood samples were collected prior to dosing and for up to 60 minutes post-dosing. Plasma concentration-time profiles of Tripeptide-1 and its l-histidyl-l-lysine metabolite indicated that neither was detected in predose plasma samples. However, after intravenous (IV) injection, Tripeptide-1 was rapidly degraded to l histidyl-l-lysine, rapidly eliminated from circulating blood. It has been reported that Tripeptide-1 is unstable in human plasma and is rapidly degraded by aminopeptidases[1].

References

[1] Wilbur Johnson. “Safety Assessment of Tripeptide-1, Hexapeptide-12, Their Metal Salts and Fatty Acyl Derivatives, and Palmitoyl Tetrapeptide-7 as Used in Cosmetics.” International Journal of Toxicology 37 1 (2018): 102S–90S.

Tripeptide-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Tripeptide-1 manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
Tripeptide-1 72957-37-0
Price
US $30.00/box
Min. Order
1box
Purity
98%
Supply Ability
5000box
Release date
2024-03-20
Strong peptide cross-border e-commerce Co. LTD
Product
Tripeptide-1 72957-37-0
Price
US $80.00-75.00/box
Min. Order
1box
Purity
99+
Supply Ability
2000box
Release date
2024-05-27
Strong peptide cross-border e-commerce Co. LTD
Product
Tripeptide-1 72957-37-0
Price
US $80.00-75.00/box
Min. Order
1box
Purity
99+
Supply Ability
2000box
Release date
2024-05-27

72957-37-0, Tripeptide-1Related Search:

TRIPEPTIDE-1 Biotinoyl tripeptide-1 Nonapeptide-1 Acetyltetrapeptide 11 histidyl-arginyl-alanyl-tryptophyl-phenylalanyl-lysinamide Tripeptide-10 citrulline Acetyl Hexapeptide-1 L-Carnosine Copper Peptide Tripeptide-3 L-Lysyl-L-alpha-aspartyl-L-valyl-N5-(aminocarbonyl)-L-ornithine H-GLY-PRO-HYP-OH Tripeptide-41 collagen tripeptide(CTP) PAL-GHK Pal-Tripeptide-1 PalmitoylTripeptide L-Lysine monoacetate

  • H-GLY-HIS-LYS-OH ACETATE SALT
  • H-GLY-HIS-LYS-OH ACOH
  • GLY-HIS-LYS ACETATE
  • GLY-HIS-LYS ACETATE SALT
  • GLY-HIS-LYS ACOH H2O
  • GLYCYL-L-HISTIDYL-L-LYSINE ACETATE
  • LIVER CELL GROWTH FACTOR
  • LIVER CELL GROWTH FACTOR ACETATE SALT
  • LIVER-CELL GROWTH FACTOR ACOH H2O
  • N2-(N-glycyl-L-histidyl)-L-lysine monoacetate
  • GLY-HIS-LYS ACETATE CELL CULTURE TESTED
  • GLYCYL-L-HISTIDYL-L-LYSIN ACETAT HYDRAT
  • GLYCINE-L-HISTIDINE-L-LYSINE extrapure
  • sh-oligopeptide-1 EGF
  • NanoLiposomal OLIGOPEPTIDE-1(TRIPEPTIDE-1)
  • Gly-His-Lys-OEt
  • Liver Cell Growth Factor Gly-His-Lys
  • (2S)-6-amino-2-[[(2S)-2-(glycylamino)-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoic acid
  • (2S)-6-azanyl-2-[[(2S)-2-(2-azanylethanoylamino)-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoic acid
  • Glycine-L-histidine-L-lysine(orHOAcsalt)
  • Gly-L-His-L-Lys acetate salt
  • Kollaren / Tripeptide-1/Gly-His-Lys acetate salt
  • GHK(Tripeptide-1)
  • GHK, Prezatide
  • (S)-6-Amino-2-((S)-2-(2-aminoacetamido)-3-(1H-imidazol-4-yl)propanamido)hexanoic acid compound with acetic acid (1:1)
  • Gly-His-Lys-OH·AcOH≥ 98% (Assay)
  • Tripeptide-1/Copper peptide
  • Aldenine
  • Tripeptide-1, Aldenine, Kollaren, Prezatide
  • Hilurlip
  • Liporeductyl
  • Prezatide
  • Tripeptide -1/ oligopeptide -1
  • Tripeptide-1/GHK
  • Gly-His-Lysacetatesal
  • GLY-HIS-LYS ACETATE SALT USP/EP/BP
  • Tripeptide-1/Kollaren/GHK
  • Peptide Tripeptide-1
  • Tripeptide-1 (HOAc)
  • Cosmetics Peptides Kollaren / Tripeptide-1/Gly-His-Lys Acetate Salt CAS 72957-37-0
  • Tripeptide-1 (HCl)
  • 72957-37-0 GLY-HIS-LYS ACETATE SALT
  • (S)-6-Amino-2-((S)-2-(2-aminoacetamido)-3-(1H-imidazol-4-yl)propanamido)hexanoic acid acetic acid salt
  • glycyl-L-histidyl-L-lysine compound with acetic acid (1:1)
  • GHK-HAC
  • Glycyl-histidyl-lysine monoacetate
  • Tripeptide-1/GHK CAS 72957-37-0
  • TRIPEPTIDE-1
  • GHK Tripeptide-1 Oligopeptide-1
  • Gly-His-Lys acetate salt >=97% (TLC)
  • ArkTide N31
  • 72957-37-0
  • 951-78-8
  • C16H28N6O6
  • C14H24N6O4C2H4O2
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience