KYNURENIC ACID
- Product Name
- KYNURENIC ACID
- CAS No.
- 492-27-3
- Chemical Name
- KYNURENIC ACID
- Synonyms
- NSC 58973;AKOS 235-06;KYNURENIC ACID;Quinurenic acid.;TIMTEC-BB SBB003671;KYNURENIC ACID PURE;2H5]-Kynurenic acid;4-HYDROXYQUINALDIC ACID;KynurenicAcidHydrate>Difelikefalin Impurity 9
- CBNumber
- CB3711231
- Molecular Formula
- C10H7NO3
- Formula Weight
- 189.17
- MOL File
- 492-27-3.mol
KYNURENIC ACID Property
- Melting point:
- 275 °C (dec.)(lit.)
- Boiling point:
- 324.41°C (rough estimate)
- Density
- 1.3175 (rough estimate)
- refractive index
- 1.5400 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO : 9 mg/mL (47.58 mM; Need ultrasonic and warming)
- form
- Off-white to tan powder.
- pka
- 1.08±0.30(Predicted)
- color
- White to Gray to Brown
- Water Solubility
- 8.92g/L(100 ºC)
- Merck
- 14,5327
- BRN
- 147451
- CAS DataBase Reference
- 492-27-3(CAS DataBase Reference)
- EPA Substance Registry System
- 2-Quinolinecarboxylic acid, 4-hydroxy- (492-27-3)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- K3375
- Product name
- Kynurenic acid
- Purity
- ≥98%
- Packaging
- 250mg
- Price
- $20.6
- Updated
- 2024/03/01
- Product number
- K3375
- Product name
- Kynurenic acid
- Purity
- ≥98%
- Packaging
- 5g
- Price
- $163
- Updated
- 2024/03/01
- Product number
- H0303
- Product name
- Kynurenic Acid Hydrate
- Purity
- >98.0%(T)(HPLC)
- Packaging
- 1g
- Price
- $52
- Updated
- 2023/06/20
- Product number
- H0303
- Product name
- Kynurenic Acid Hydrate
- Purity
- >98.0%(T)(HPLC)
- Packaging
- 5g
- Price
- $140
- Updated
- 2023/06/20
- Product number
- K3375
- Product name
- Kynurenic acid
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $47.1
- Updated
- 2024/03/01
KYNURENIC ACID Chemical Properties,Usage,Production
Uses
An antagonist of NMDA and AMPA/kainate receptors
Uses
Kynurenic acid has been used as a constituent in dissection saline solution for embryonic cerebral cortical cells and human primary astrocytes. It has also been used as a medium supplement for murine intestinal epithelial cell line, MODE-K and induced pluripotent stem cell (iPSC)-derived neurons cells.
Uses
A product of L-Tryptophan metabolism, possessing neruoactive activity having antiexcitotoxic and anticonvulsant properties.
Definition
ChEBI: Kynurenic acid is a quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4. It has a role as a G-protein-coupled receptor agonist, a NMDA receptor antagonist, a nicotinic antagonist, a neuroprotective agent, a human metabolite and a Saccharomyces cerevisiae metabolite. It is a monohydroxyquinoline and a quinolinemonocarboxylic acid. It is a conjugate acid of a kynurenate.
Biological Activity
Broad spectrum EAA antagonist.
Biochem/physiol Actions
Kynurenic acid (KynA) is a non-selective antagonist of N-methyl-d-aspartate (NMDA), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainate receptors. It blocks kainic acid neurotoxicity. Kynurenic acid also blocks nicotinic acetylcholine receptors. It is a by-product of tryptophan catabolic pathway. Kynurenic acid is a neuromodulator and controls the levels of glutamate, dopamine, acetylcholine and α-aminobutyric acid (GABA). KynA controls neuroendocrine functions and altered levels of KynA is a potential marker in depression, schizophrenia Alzheimer′s and Huntington′s diseases. Normal levels of KynA in the brain is crucial for the cognitive function.
storage
Room temperature
Purification Methods
Crystallise the acid from absolute EtOH. The methyl ester crystallises from MeOH with m 224-226o. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p2723 1961, Beilstein 22 II 174, 22 III/IV 2245, 22/6 V 280.]
KYNURENIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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