Sulfacarbamide
- Product Name
- Sulfacarbamide
- CAS No.
- 547-44-4
- Chemical Name
- Sulfacarbamide
- Synonyms
- a435;A 435;Uramid;Urenil;Uractyl;Euvernil;Sulfaurea;Urosulfan;NSC 78438;Sulphaurea
- CBNumber
- CB3711796
- Molecular Formula
- C7H9N3O3S
- Formula Weight
- 215.23
- MOL File
- 547-44-4.mol
Sulfacarbamide Property
- Melting point:
- 146-148° (slight dec)
- Density
- 1.4565 (rough estimate)
- refractive index
- 1.6630 (estimate)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- DMSO : ≥ 28 mg/mL (130.09 mM)
- form
- Solid
- pka
- pKa 1.78(H2O t = 25 I = 0.05) (Uncertain);5.42(H2O t = 25 I = 0.05) (Uncertain)
- color
- White to off-white
- Water Solubility
- 2.333g/L(20 ºC)
- InChI
- InChI=1S/C7H9N3O3S/c8-5-1-3-6(4-2-5)14(12,13)10-7(9)11/h1-4H,8H2,(H3,9,10,11)
- InChIKey
- WVAKABMNNSMCDK-UHFFFAOYSA-N
- SMILES
- C1(S(NC(N)=O)(=O)=O)=CC=C(N)C=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- S441104
- Product name
- 1-SULFANILYLUREA
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $179
- Updated
- 2024/03/01
- Product number
- S688945
- Product name
- Sulfacarbamide
- Packaging
- 1g
- Price
- $115
- Updated
- 2021/12/16
- Product number
- S688947
- Product name
- Sulfacarbamide-d4
- Packaging
- 1mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 7956AB
- Product name
- 4-Amino-N-carbamoylbenzenesulfonamide
- Packaging
- 25mg
- Price
- $96
- Updated
- 2021/12/16
- Product number
- 7956AB
- Product name
- 4-Amino-N-carbamoylbenzenesulfonamide
- Packaging
- 100mg
- Price
- $126
- Updated
- 2021/12/16
Sulfacarbamide Chemical Properties,Usage,Production
Description
Sulfacarbamide is a blood sugar-lowering drug, also acting on the vegetative nervous system.
Chemical Properties
White solid
Uses
Sulfacarbamide-d4 is the labeled analogue of Sulfacarbamide (S688945), an antibiotic which is rapidly absorbed in blister fluid.
Uses
antibacterial
Definition
ChEBI: Sulfacarbamide is a sulfonamide and a member of benzenes.
World Health Organization (WHO)
Sulfacarbamide, a sulfonamide anti-infective agent, was introduced in the 1940's for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing bacterial resistance and their replacement by antibiotics which are generally more active and less toxic. The Sulfacarbamide are known to cause serious adverse effects such as renal toxicity, sometimes fatal exfoliative dermatitis and erythema multiforma and dangerous adverse reactions affecting blood formation such as agranulocytosis and haemolytic or aplastic anaemia. Sulfacarbamide still remains available in at least one country for the treatment of urinary infections.
Mechanism of action
Sulfonylureas bind to and inhibit the ATP-sensitive potassium channels (K) on the pancreatic beta cells. As a result, potassium efflux decreases, and the beta-cell membrane depolarizes. Membrane depolarization causes calcium channels to open, leading to calcium influx and increased intracellular calcium, which stimulates insulin secretion from the pancreatic beta cells. Sulfonylureas cause insulin release regardless of blood glucose levels.
Sulfacarbamide Preparation Products And Raw materials
Raw materials
Preparation Products
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