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6-Aminoquinoxaline

Product Name
6-Aminoquinoxaline
CAS No.
6298-37-9
Chemical Name
6-Aminoquinoxaline
Synonyms
quinoxalin-6-amine;6-aminooxoline;6-AminoquinoxaL;6-QUINOXALINAMINE;6-Quinoxalineamine;6-AMINOQUINOXALINE;6-aminoquinazaline;Quinoxaline-6-amine;6-QUINOXALINYLAMINE;QUINOXALIN-6-YLAMINE
CBNumber
CB3712935
Molecular Formula
C8H7N3
Formula Weight
145.16
MOL File
6298-37-9.mol
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6-Aminoquinoxaline Property

Melting point:
159 °C
Boiling point:
254.27°C (rough estimate)
Density 
1.2109 (rough estimate)
refractive index 
1.5400 (estimate)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
2.57±0.30(Predicted)
color 
Yellow to Dark Yellow
InChI
InChI=1S/C8H7N3/c9-6-1-2-7-8(5-6)11-4-3-10-7/h1-5H,9H2
InChIKey
MSGRFBKVMUKEGZ-UHFFFAOYSA-N
SMILES
N1C2C(=CC(N)=CC=2)N=CC=1
CAS DataBase Reference
6298-37-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-36/38-22
Safety Statements 
24/25-36/39-26
WGK Germany 
1
HazardClass 
IRRITANT
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
730505
Product name
6-Aminoquinoxaline
Purity
95%
Packaging
250mg
Price
$91.4
Updated
2022/05/15
TCI Chemical
Product number
A2490
Product name
6-Aminoquinoxaline
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$44
Updated
2025/07/31
TCI Chemical
Product number
A2490
Product name
6-Aminoquinoxaline
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$132
Updated
2025/07/31
TRC
Product number
Q750010
Product name
6-Quinoxalinamine
Packaging
5G
Price
$125
Updated
2021/12/16
TRC
Product number
Q750010
Product name
6-Quinoxalinamine
Packaging
1g
Price
$55
Updated
2021/12/16
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6-Aminoquinoxaline Chemical Properties,Usage,Production

Chemical Properties

Yellow solid

Uses

6-Quinoxalinamine is used in the synthetic preparation and evaluation of novel nitroheterocyclic hypoxic markers for solid tumor.

Definition

ChEBI: 6-Quinoxalinamine is a quinoxaline derivative.

Synthesis

6639-87-8

6298-37-9

General procedure for the synthesis of 6-aminoquinoxaline from 6-nitroquinoxaline: 10% palladium carbon (50 mg) was added to a solution of 6-nitroquinoxaline (500 mg, 2.86 mmol) in methanol (20 mL) and the reaction mixture was stirred for 4 hr. under an atmosphere of hydrogen at 1 atm. Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration and the filtrate was evaporated to remove the solvent. The residue was purified by silica column chromatography followed by evaporation of the solvent to afford 6-aminoquinoxaline as a yellow solid (342 mg, 82% yield) with a thin layer chromatography (TLC) Rf value of 0.32 (unfolding agent: ethyl acetate). The product was characterized by 1H NMR (CDCl3): δ 8.65 (1H, d, J=1.7 Hz), 8.55 (1H, d, J=1.7 Hz), 7.87 (1H, d, J=8.9 Hz), 7.18 (1H, dd, J=8.9,2.5 Hz), 7.13 (1H, d, J=2.5 Hz), 4.20 (2H, br. s, -NH2).

References

[1] Patent: US2012/178748, 2012, A1. Location in patent: Page/Page column 43
[2] Patent: WO2013/6792, 2013, A1. Location in patent: Paragraph 0170
[3] Patent: WO2005/42513, 2005, A1. Location in patent: Page/Page column 71
[4] Heterocycles, 2007, vol. 72, p. 353 - 361
[5] Journal of Medicinal Chemistry, 2016, vol. 59, # 13, p. 6169 - 6186

6-Aminoquinoxaline Preparation Products And Raw materials

Raw materials

GLYOXAL SODIUM BISULFITE 4-Nitro-o-phenylenediamine Ethanol Palladium

Preparation Products

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6-Aminoquinoxaline Suppliers

Americas 1 Belgium 1 China 234 Czech Republic 2 Europe 1 France 1 Germany 2 Hungary 1 India 27 Japan 3 Russia 2 Switzerland 1 The Netherlands 1 United Kingdom 14 United States 25 Global 316
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
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View Lastest Price from 6-Aminoquinoxaline manufacturers

Zhengzhou Anbu Chem Co.,Ltd
Product
6-Aminoquinoxaline 6298-37-9
Price
US $0.00/KG
Min. Order
0.1KG
Purity
98%
Supply Ability
1000KGS
Release date
2023-07-14
Hebei Zhanyao Biotechnology Co. Ltd
Product
6-Aminoquinoxaline 6298-37-9
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 Tons
Release date
2021-10-13
Zhuozhou Wenxi import and Export Co., Ltd
Product
6-Aminoquinoxaline 6298-37-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

6298-37-9, 6-AminoquinoxalineRelated Search:

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  • Building Blocks
  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • Quinoxalines
  • Quinolines, Quinazolines and derivatives
  • pharmacetical
  • Amines
  • Quinolines, Isoquinolines & Quinoxalines
  • Quinolines, Isoquinolines & Quinoxalines