6-Aminoquinoxaline
- Product Name
- 6-Aminoquinoxaline
- CAS No.
- 6298-37-9
- Chemical Name
- 6-Aminoquinoxaline
- Synonyms
- quinoxalin-6-amine;6-aminooxoline;6-AminoquinoxaL;6-QUINOXALINAMINE;6-Quinoxalineamine;6-AMINOQUINOXALINE;6-aminoquinazaline;Quinoxaline-6-amine;6-QUINOXALINYLAMINE;QUINOXALIN-6-YLAMINE
- CBNumber
- CB3712935
- Molecular Formula
- C8H7N3
- Formula Weight
- 145.16
- MOL File
- 6298-37-9.mol
6-Aminoquinoxaline Property
- Melting point:
- 159 °C
- Boiling point:
- 254.27°C (rough estimate)
- Density
- 1.2109 (rough estimate)
- refractive index
- 1.5400 (estimate)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 2.57±0.30(Predicted)
- color
- Yellow to Dark Yellow
- InChI
- InChI=1S/C8H7N3/c9-6-1-2-7-8(5-6)11-4-3-10-7/h1-5H,9H2
- InChIKey
- MSGRFBKVMUKEGZ-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC(N)=CC=2)N=CC=1
- CAS DataBase Reference
- 6298-37-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-36/38-22
- Safety Statements
- 24/25-36/39-26
- WGK Germany
- 1
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 730505
- Product name
- 6-Aminoquinoxaline
- Purity
- 95%
- Packaging
- 250mg
- Price
- $91.4
- Updated
- 2022/05/15
- Product number
- A2490
- Product name
- 6-Aminoquinoxaline
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $44
- Updated
- 2025/07/31
- Product number
- A2490
- Product name
- 6-Aminoquinoxaline
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $132
- Updated
- 2025/07/31
- Product number
- Q750010
- Product name
- 6-Quinoxalinamine
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- Q750010
- Product name
- 6-Quinoxalinamine
- Packaging
- 5G
- Price
- $125
- Updated
- 2021/12/16
6-Aminoquinoxaline Chemical Properties,Usage,Production
Chemical Properties
Yellow solid
Uses
6-Quinoxalinamine is used in the synthetic preparation and evaluation of novel nitroheterocyclic hypoxic markers for solid tumor.
Definition
ChEBI: 6-Quinoxalinamine is a quinoxaline derivative.
Synthesis
6639-87-8
6298-37-9
General procedure for the synthesis of 6-aminoquinoxaline from 6-nitroquinoxaline: 10% palladium carbon (50 mg) was added to a solution of 6-nitroquinoxaline (500 mg, 2.86 mmol) in methanol (20 mL) and the reaction mixture was stirred for 4 hr. under an atmosphere of hydrogen at 1 atm. Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration and the filtrate was evaporated to remove the solvent. The residue was purified by silica column chromatography followed by evaporation of the solvent to afford 6-aminoquinoxaline as a yellow solid (342 mg, 82% yield) with a thin layer chromatography (TLC) Rf value of 0.32 (unfolding agent: ethyl acetate). The product was characterized by 1H NMR (CDCl3): δ 8.65 (1H, d, J=1.7 Hz), 8.55 (1H, d, J=1.7 Hz), 7.87 (1H, d, J=8.9 Hz), 7.18 (1H, dd, J=8.9,2.5 Hz), 7.13 (1H, d, J=2.5 Hz), 4.20 (2H, br. s, -NH2).
References
[1] Patent: US2012/178748, 2012, A1. Location in patent: Page/Page column 43
[2] Patent: WO2013/6792, 2013, A1. Location in patent: Paragraph 0170
[3] Patent: WO2005/42513, 2005, A1. Location in patent: Page/Page column 71
[4] Heterocycles, 2007, vol. 72, p. 353 - 361
[5] Journal of Medicinal Chemistry, 2016, vol. 59, # 13, p. 6169 - 6186
6-Aminoquinoxaline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Aminoquinoxaline manufacturers
- Product
- 6-Aminoquinoxaline 6298-37-9
- Price
- US $0.00/KG
- Min. Order
- 0.1KG
- Purity
- 98%
- Supply Ability
- 1000KGS
- Release date
- 2023-07-14
- Product
- 6-Aminoquinoxaline 6298-37-9
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2021-10-13
- Product
- 6-Aminoquinoxaline 6298-37-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10