PNU 37883 hydrochloride

Product Name: PNU 37883 hydrochloride
CAS No.: 57568-80-6
Chemical Name: PNU 37883 hydrochloride
Synonyms: U-37883A;PNU 37883 HCl;PNU 37883 hydrochlor;PNU 37883 HYDROCHLORIDE;U-37883A, ATP-sensitive K+ channel blocker;N-CYCLOHEXYL-N'-TRICYCLO[3.3.1.1(3,7)]DEC-1-YL-4-MORPHOLINECARBOXIMIDAMIDE HYDROCHLORIDE
CBNumber: CB3714151
Molecular Formula: C21H36ClN3O
Formula Weight: 381.98
MOL File: 57568-80-6.mol

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PNU 37883 hydrochloride Property

RTECS: QD9865500
storage temp.: 2-8°C
solubility: DMSO: ~23 mg/mL
form: powder
color: white

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 2095
Product name: PNU37883hydrochloride
Purity: ≥99%(HPLC)
Packaging: 10
Price: $169
Updated: 2021/12/16

Tocris

Product number: 2095
Product name: PNU37883hydrochloride
Purity: ≥99%(HPLC)
Packaging: 50
Price: $711
Updated: 2021/12/16

Usbiological

Product number: 256296
Product name: PNU 37883 hydrochloride
Packaging: 10mg
Price: $423
Updated: 2021/12/16

ApexBio Technology

Product number: B6948
Product name: PNU37883hydrochloride
Packaging: 50mg
Price: $1053
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BRS0000190
Product name: PNU-37883
Purity: 95.00%
Packaging: 50MG
Price: $1170.31
Updated: 2021/12/16

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PNU 37883 hydrochloride Chemical Properties,Usage,Production

Uses

PNU 37883 hydrochloride (PNU 37883A) is a selective vascular ATP-sensitive potassium (Kir6, KATP) channels blocker. PNU 37883 hydrochloride has diuretic effects with specific binding in kidney and vascular smooth muscle rather than in brain or pancreatic beta cells[1][2].

Biological Activity

Novel antagonist selective for the vascular form of K ATP channel; inhibits K ATP currents in isolated mesenteric artery smooth muscle cells (K d = 65 nM) but not in cardiac or skeletal myocytes. In vivo, inhibits blood vessel relaxation and hypotension induced by pinacidil. Displays weak diuretic effects.

storage

room temperature (desiccate)

References

[1] Yi Cui, et al. Different molecular sites of action for the KATP channel inhibitors, PNU-99963 and PNU-37883A. Br J Pharmacol. 2003 May;139(1):122-8. DOI:10.1038/sj.bjp.0705228
[2] Noriyoshi Teramoto. Pharmacological Profile of U-37883A, a Channel Blocker of Smooth Muscle-Type ATP-Sensitive K Channels. Cardiovasc Drug Rev. Spring 2006;24(1):25-32. DOI:10.1111/j.1527-3466.2006.00025.x
[3] Guang-Yuan Mar, et al. Changes of imidazoline receptors in spontaneously hypertensive rats. Int J Exp Pathol. 2013 Feb;94(1):17-24. DOI:10.1111/iep.12000

PNU 37883 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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57568-80-6, PNU 37883 hydrochlorideRelated Search:

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PNU 37883 HYDROCHLORIDE

N-CYCLOHEXYL-N'-TRICYCLO[3.3.1.1(3,7)]DEC-1-YL-4-MORPHOLINECARBOXIMIDAMIDE HYDROCHLORIDE

U-37883A

PNU 37883 hydrochlor

PNU 37883 HCl

U-37883A, ATP-sensitive K+ channel blocker

57568-80-6

C21H35N3OHCl

C21H36ClN3O

Potassium channel