PNU 37883 hydrochloride
- Product Name
- PNU 37883 hydrochloride
- CAS No.
- 57568-80-6
- Chemical Name
- PNU 37883 hydrochloride
- Synonyms
- U-37883A;PNU 37883 HCl;PNU 37883 hydrochlor;PNU 37883 HYDROCHLORIDE;U-37883A, ATP-sensitive K+ channel blocker;N-CYCLOHEXYL-N'-TRICYCLO[3.3.1.1(3,7)]DEC-1-YL-4-MORPHOLINECARBOXIMIDAMIDE HYDROCHLORIDE
- CBNumber
- CB3714151
- Molecular Formula
- C21H36ClN3O
- Formula Weight
- 381.98
- MOL File
- 57568-80-6.mol
PNU 37883 hydrochloride Property
- RTECS
- QD9865500
- storage temp.
- 2-8°C
- solubility
- DMSO: ~23 mg/mL
- form
- powder
- color
- white
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- 2095
- Product name
- PNU37883hydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $169
- Updated
- 2021/12/16
- Product number
- 2095
- Product name
- PNU37883hydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $711
- Updated
- 2021/12/16
- Product number
- 256296
- Product name
- PNU 37883 hydrochloride
- Packaging
- 10mg
- Price
- $423
- Updated
- 2021/12/16
- Product number
- B6948
- Product name
- PNU37883hydrochloride
- Packaging
- 50mg
- Price
- $1053
- Updated
- 2021/12/16
- Product number
- BRS0000190
- Product name
- PNU-37883
- Purity
- 95.00%
- Packaging
- 50MG
- Price
- $1170.31
- Updated
- 2021/12/16
PNU 37883 hydrochloride Chemical Properties,Usage,Production
Uses
PNU 37883 hydrochloride (PNU 37883A) is a selective vascular ATP-sensitive potassium (Kir6, KATP) channels blocker. PNU 37883 hydrochloride has diuretic effects with specific binding in kidney and vascular smooth muscle rather than in brain or pancreatic beta cells[1][2].
Biological Activity
Novel antagonist selective for the vascular form of K ATP channel; inhibits K ATP currents in isolated mesenteric artery smooth muscle cells (K d = 65 nM) but not in cardiac or skeletal myocytes. In vivo, inhibits blood vessel relaxation and hypotension induced by pinacidil. Displays weak diuretic effects.
storage
room temperature (desiccate)
References
[1] Yi Cui, et al. Different molecular sites of action for the KATP channel inhibitors, PNU-99963 and PNU-37883A. Br J Pharmacol. 2003 May;139(1):122-8. DOI:10.1038/sj.bjp.0705228
[2] Noriyoshi Teramoto. Pharmacological Profile of U-37883A, a Channel Blocker of Smooth Muscle-Type ATP-Sensitive K Channels. Cardiovasc Drug Rev. Spring 2006;24(1):25-32. DOI:10.1111/j.1527-3466.2006.00025.x
[3] Guang-Yuan Mar, et al. Changes of imidazoline receptors in spontaneously hypertensive rats. Int J Exp Pathol. 2013 Feb;94(1):17-24. DOI:10.1111/iep.12000
PNU 37883 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
PNU 37883 hydrochloride Suppliers
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- sales@chemos-group.com
- Country
- Germany
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- info@biotrend.ch
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