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Phosphonoformic acid trisodium salt hexahydrate

Product Name
Phosphonoformic acid trisodium salt hexahydrate
CAS No.
34156-56-4
Chemical Name
Phosphonoformic acid trisodium salt hexahydrate
Synonyms
PFA Hydrate;Gefin Hydrate;EHB 776 Hydrate;A 29622 Hydrate;Foscavir Hydrate;FORSCARNETSODIUM;phosphonatoformate;Triapten Hexahydrate;Foscarnet Sodium(PFA);Foscarnet Sodium (50 mg)
CBNumber
CB3714429
Molecular Formula
CH6NaO6P
Formula Weight
168.02
MOL File
34156-56-4.mol
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Phosphonoformic acid trisodium salt hexahydrate Property

storage temp. 
2-8°C
solubility 
H2O: 0.1 g/mL hot, clear, colorless
Water Solubility 
Soluble in water.
InChIKey
ILRVASBWNRYBFD-UHFFFAOYSA-K
CAS DataBase Reference
34156-56-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
SY8300000
HS Code 
29319090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H341Suspected of causing genetic defects

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P6801
Product name
Sodium phosphonoformate tribasic hexahydrate
Packaging
1g
Price
$94.1
Updated
2024/03/01
Sigma-Aldrich
Product number
BP623
Product name
Foscarnet sodium
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$269
Updated
2024/03/01
Sigma-Aldrich
Product number
1283302
Product name
Foscarnet sodium
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
50mg
Price
$436
Updated
2024/03/01
Alfa Aesar
Product number
B24784
Product name
Sodium phosphonoformate hexahydrate, 98+%
Packaging
1g
Price
$92.65
Updated
2024/03/01
Alfa Aesar
Product number
B24784
Product name
Sodium phosphonoformate hexahydrate, 98+%
Packaging
5g
Price
$297.65
Updated
2024/03/01
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Phosphonoformic acid trisodium salt hexahydrate Chemical Properties,Usage,Production

Chemical Properties

Phosphonoformic acid trisodium salt hexahydrate is white or almost white, crystalline powder.

Uses

Sodium phosphonoformate hexahydrate acts as an antiviral agent and reverse transcriptase inhibitor. It is also used to inhibit viral DNA polymerase. Further, it is used as a type II Pi transporter inhibitor.

Uses

Foscarnet inhibits viral DNA polymerase and reverse transcriptase. Foscarnet is used as an antiviral.

Definition

ChEBI: The hexahydrate form of trisodium phosphonoformate. It is used as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patien s who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.

Acquired resistance

Phosphonoformic acid trisodium salt hexahydrate can be generated in vitro, and CMV strains resistant to both ganciclovir and foscarnet have occasionally been recovered from humans.

Pharmaceutical Applications

Phosphonoformic acid trisodium salt hexahydrate is a synthetic non-nucleoside pyrophosphate analog formulated as the trisodium hexahydrate for intravenous use. The solubility in water at pH 7 is only about 5% (w/w).

Pharmacokinetics

Oral absorption: c. 17%
Cmax 60 mg/kg intravenous 8-hourly: 557 μmol/L
Plasma half-life: 3.3–6.8 h
Volume of distribution: 0.52–0.74 L/kg
Plasma protein binding: 14–17%
Absorption and distribution
Oral bioavailability is poor. A wide range of plasma concentrations was noted (75–500 μmol/L) during 3–21 days of continuous intravenous infusion of 0.14–0.19 mg/kg per min. During continuous intravenous therapy the concentrations reached a plateau on day 3. Considerable differences in steady-state plasma concentrations exist between individuals. Drug penetrates the CSF; the mean concentration is about 40–60% of the mean plasma concentration, depending upon dose.
Metabolism and excretion
Elimination appears to be triphasic, with two initially short half-lives of 0.5–1.4 h and 3.3–6.8 h, followed by a long terminal phase of 88 h. About 88% of the cumulative intravenous dose is recovered unchanged in the urine within a week of stopping an infusion, indicating that the drug is not significantly metabolized. Non-renal clearance accounts for 14–18% of total clearance and may relate to uptake into bone. Plasma clearance decreases markedly with decreased renal function and the elimination half-life may be increased by up to 10-fold. Conventional dialysis eliminates about 25% of a dose while high-flux dialysis can remove nearly 60%.

Clinical Use

Treatment of CMV retinitis in patients for whom ganciclovir is contraindicated, inappropriate or ineffective
It is also potentially of value in the treatment of aciclovir-resistant HSV infection.

Side effects

Treatment is more frequently limited by toxicity than with ganciclovir. Renal toxicity is most common. A two- to three-fold increase in serum creatinine levels occurs in 20–60% (mean 45%) of patients given 130–230 mg/kg per day as a continuous intravenous infusion. Renal impairment usually develops within the first few weeks of treatment and is generally reversible within several weeks of discontinuing therapy. Foscarnet chelates metal ions, and serum electrolyte abnormalities – predominantly hypocalcemia, hypomagnesemia, hypokalemia and hypophosphatemia – occur in about 30, 15, 16 and 8% of patients, respectively. Convulsions occur in 10–15%. Other side effects include anemia (25–50%), penile or vulval ulceration (3–9%), nausea and vomiting (20–30%), local irritation and thrombophlebitis at the infusion site, abdominal pain and occasional pancreatitis, headache (c. 25%), dizziness, involuntary muscle contractions, tremor, hypoesthesia, ataxia, neuropathy, anxiety, nervousness, depression and confusion, and skin rash. Nephrogenic diabetes insipidus has been reported.
Foscarnet is contraindicated in pregnancy. Topical application does not result in dermal toxicity similar to that produced by phosphonacetic acid.

Phosphonoformic acid trisodium salt hexahydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Phosphonoformic acid trisodium salt hexahydrate Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94838
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76
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10194
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62
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2127
Advantage
70
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15421
Advantage
60
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-0712-2580635 15527768850
Email
1791901229@qq.com
Country
China
ProdList
8850
Advantage
52
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9823
Advantage
79
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9664
Advantage
60
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14059
Advantage
65
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View Lastest Price from Phosphonoformic acid trisodium salt hexahydrate manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Phosphonoformic acid trisodium salt hexahydrate 34156-56-4
Price
US $1.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 Tons
Release date
2020-01-14
Career Henan Chemical Co
Product
Phosphonoformic acid trisodium salt hexahydrate 34156-56-4
Price
US $7.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-18

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