Phosphonoformic acid trisodium salt hexahydrate
- Product Name
- Phosphonoformic acid trisodium salt hexahydrate
- CAS No.
- 34156-56-4
- Chemical Name
- Phosphonoformic acid trisodium salt hexahydrate
- Synonyms
- PFA Hydrate;Gefin Hydrate;EHB 776 Hydrate;A 29622 Hydrate;Foscavir Hydrate;FORSCARNETSODIUM;phosphonatoformate;Triapten Hexahydrate;Foscarnet Sodium(PFA);Foscarnet Sodium (50 mg)
- CBNumber
- CB3714429
- Molecular Formula
- CH6NaO6P
- Formula Weight
- 168.02
- MOL File
- 34156-56-4.mol
Phosphonoformic acid trisodium salt hexahydrate Property
- storage temp.
- 2-8°C
- solubility
- H2O: 0.1 g/mL hot, clear, colorless
- form
- Solid
- color
- White to off-white
- Water Solubility
- Soluble in water.
- InChIKey
- ILRVASBWNRYBFD-UHFFFAOYSA-K
- CAS DataBase Reference
- 34156-56-4(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H341Suspected of causing genetic defects
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- P6801
- Product name
- Sodium phosphonoformate tribasic hexahydrate
- Packaging
- 1g
- Price
- $94.1
- Updated
- 2024/03/01
- Product number
- BP623
- Product name
- Foscarnet sodium
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 100MG
- Price
- $269
- Updated
- 2024/03/01
- Product number
- 1283302
- Product name
- Foscarnet sodium
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 50mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- B24784
- Product name
- Sodium phosphonoformate hexahydrate, 98+%
- Packaging
- 1g
- Price
- $92.65
- Updated
- 2024/03/01
- Product number
- B24784
- Product name
- Sodium phosphonoformate hexahydrate, 98+%
- Packaging
- 5g
- Price
- $297.65
- Updated
- 2024/03/01
Phosphonoformic acid trisodium salt hexahydrate Chemical Properties,Usage,Production
Chemical Properties
Phosphonoformic acid trisodium salt hexahydrate is white or almost white, crystalline powder.
Uses
Sodium phosphonoformate hexahydrate acts as an antiviral agent and reverse transcriptase inhibitor. It is also used to inhibit viral DNA polymerase. Further, it is used as a type II Pi transporter inhibitor.
Uses
Foscarnet inhibits viral DNA polymerase and reverse transcriptase. Foscarnet is used as an antiviral.
Definition
ChEBI: The hexahydrate form of trisodium phosphonoformate. It is used as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patien s who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.
Acquired resistance
Phosphonoformic acid trisodium salt hexahydrate can be generated in vitro, and CMV strains resistant to both ganciclovir and foscarnet have occasionally been recovered from humans.
Pharmaceutical Applications
Phosphonoformic acid trisodium salt hexahydrate is a synthetic non-nucleoside pyrophosphate analog formulated as the trisodium hexahydrate for intravenous use. The solubility in water at pH 7 is only about 5% (w/w).
Pharmacokinetics
Oral absorption: c. 17%
Cmax 60 mg/kg intravenous 8-hourly: 557 μmol/L
Plasma half-life: 3.3–6.8 h
Volume of distribution: 0.52–0.74 L/kg
Plasma protein binding: 14–17%
Absorption and distribution
Oral bioavailability is poor. A wide range of plasma concentrations was noted (75–500 μmol/L) during 3–21 days of continuous intravenous infusion of 0.14–0.19 mg/kg per min. During continuous intravenous therapy the concentrations reached a plateau on day 3. Considerable differences in steady-state plasma concentrations exist between individuals. Drug penetrates the CSF; the mean concentration is about 40–60% of the mean plasma concentration, depending upon dose.
Metabolism and excretion
Elimination appears to be triphasic, with two initially short half-lives of 0.5–1.4 h and 3.3–6.8 h, followed by a long terminal phase of 88 h. About 88% of the cumulative intravenous dose is recovered unchanged in the urine within a week of stopping an infusion, indicating that the drug is not significantly metabolized. Non-renal clearance accounts for 14–18% of total clearance and may relate to uptake into bone. Plasma clearance decreases markedly with decreased renal function and the elimination half-life may be increased by up to 10-fold. Conventional dialysis eliminates about 25% of a dose while high-flux dialysis can remove nearly 60%.
Clinical Use
Treatment of CMV retinitis in patients for whom ganciclovir is
contraindicated, inappropriate or ineffective
It is also potentially of value in the treatment of aciclovir-resistant
HSV infection.
Side effects
Treatment is more frequently limited by toxicity than with ganciclovir.
Renal toxicity is most common. A two- to three-fold
increase in serum creatinine levels occurs in 20–60% (mean
45%) of patients given 130–230 mg/kg per day as a continuous
intravenous infusion. Renal impairment usually develops
within the first few weeks of treatment and is generally reversible
within several weeks of discontinuing therapy. Foscarnet
chelates metal ions, and serum electrolyte abnormalities –
predominantly hypocalcemia, hypomagnesemia, hypokalemia
and hypophosphatemia – occur in about 30, 15, 16 and 8%
of patients, respectively. Convulsions occur in 10–15%. Other
side effects include anemia (25–50%), penile or vulval ulceration
(3–9%), nausea and vomiting (20–30%), local irritation
and thrombophlebitis at the infusion site, abdominal pain and
occasional pancreatitis, headache (c. 25%), dizziness, involuntary
muscle contractions, tremor, hypoesthesia, ataxia, neuropathy,
anxiety, nervousness, depression and confusion, and
skin rash. Nephrogenic diabetes insipidus has been reported.
Foscarnet is contraindicated in pregnancy. Topical application
does not result in dermal toxicity similar to that produced
by phosphonacetic acid.
Phosphonoformic acid trisodium salt hexahydrate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Phosphonoformic acid trisodium salt hexahydrate manufacturers
- Product
- Phosphonoformic acid trisodium salt hexahydrate 34156-56-4
- Price
- US $1.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2020-01-14
- Product
- Phosphonoformic acid trisodium salt hexahydrate 34156-56-4
- Price
- US $32.00-1.10/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-22
- Product
- Phosphonoformic acid trisodium salt hexahydrate 34156-56-4
- Price
- US $7.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-18