Phosphonoformic acid trisodium salt hexahydrate

ChemicalBook > CAS DataBase List > Phosphonoformic acid trisodium salt hexahydrate

Phosphonoformic acid trisodium salt hexahydrate

Product Name: Phosphonoformic acid trisodium salt hexahydrate
CAS No.: 34156-56-4
Chemical Name: Phosphonoformic acid trisodium salt hexahydrate
Synonyms: PFA Hydrate;Gefin Hydrate;EHB 776 Hydrate;A 29622 Hydrate;Foscavir Hydrate;FORSCARNETSODIUM;phosphonatoformate;Triapten Hexahydrate;Foscarnet Sodium(PFA);Foscarnet Sodium (50 mg)
CBNumber: CB3714429
Molecular Formula: CH6NaO6P
Formula Weight: 168.02
MOL File: 34156-56-4.mol

Less

Phosphonoformic acid trisodium salt hexahydrate Property

storage temp.: 2-8°C
solubility: H₂O: 0.1 g/mL hot, clear, colorless
Water Solubility: Soluble in water.
InChIKey: ILRVASBWNRYBFD-UHFFFAOYSA-K
CAS DataBase Reference: 34156-56-4(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: SY8300000
HS Code: 29319090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H341Suspected of causing genetic defects

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P6801
Product name: Sodium phosphonoformate tribasic hexahydrate
Packaging: 1g
Price: $94.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: BP623
Product name: Foscarnet sodium
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 100MG
Price: $269
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1283302
Product name: Foscarnet sodium
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 50mg
Price: $436
Updated: 2024/03/01

Alfa Aesar

Product number: B24784
Product name: Sodium phosphonoformate hexahydrate, 98+%
Packaging: 1g
Price: $92.65
Updated: 2024/03/01

Alfa Aesar

Product number: B24784
Product name: Sodium phosphonoformate hexahydrate, 98+%
Packaging: 5g
Price: $297.65
Updated: 2024/03/01

Less

Phosphonoformic acid trisodium salt hexahydrate Chemical Properties,Usage,Production

Chemical Properties

Phosphonoformic acid trisodium salt hexahydrate is white or almost white, crystalline powder.

Uses

Sodium phosphonoformate hexahydrate acts as an antiviral agent and reverse transcriptase inhibitor. It is also used to inhibit viral DNA polymerase. Further, it is used as a type II Pi transporter inhibitor.

Uses

Foscarnet inhibits viral DNA polymerase and reverse transcriptase. Foscarnet is used as an antiviral.

Definition

ChEBI: The hexahydrate form of trisodium phosphonoformate. It is used as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patien s who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.

Acquired resistance

Phosphonoformic acid trisodium salt hexahydrate can be generated in vitro, and CMV strains resistant to both ganciclovir and foscarnet have occasionally been recovered from humans.

Pharmaceutical Applications

Phosphonoformic acid trisodium salt hexahydrate is a synthetic non-nucleoside pyrophosphate analog formulated as the trisodium hexahydrate for intravenous use. The solubility in water at pH 7 is only about 5% (w/w).

Pharmacokinetics

Oral absorption: c. 17%
C_max 60 mg/kg intravenous 8-hourly: 557 μmol/L
Plasma half-life: 3.3–6.8 h
Volume of distribution: 0.52–0.74 L/kg
Plasma protein binding: 14–17%
Absorption and distribution
Oral bioavailability is poor. A wide range of plasma concentrations was noted (75–500 μmol/L) during 3–21 days of continuous intravenous infusion of 0.14–0.19 mg/kg per min. During continuous intravenous therapy the concentrations reached a plateau on day 3. Considerable differences in steady-state plasma concentrations exist between individuals. Drug penetrates the CSF; the mean concentration is about 40–60% of the mean plasma concentration, depending upon dose.
Metabolism and excretion
Elimination appears to be triphasic, with two initially short half-lives of 0.5–1.4 h and 3.3–6.8 h, followed by a long terminal phase of 88 h. About 88% of the cumulative intravenous dose is recovered unchanged in the urine within a week of stopping an infusion, indicating that the drug is not significantly metabolized. Non-renal clearance accounts for 14–18% of total clearance and may relate to uptake into bone. Plasma clearance decreases markedly with decreased renal function and the elimination half-life may be increased by up to 10-fold. Conventional dialysis eliminates about 25% of a dose while high-flux dialysis can remove nearly 60%.

Clinical Use

Treatment of CMV retinitis in patients for whom ganciclovir is contraindicated, inappropriate or ineffective
It is also potentially of value in the treatment of aciclovir-resistant HSV infection.

Side effects

Treatment is more frequently limited by toxicity than with ganciclovir. Renal toxicity is most common. A two- to three-fold increase in serum creatinine levels occurs in 20–60% (mean 45%) of patients given 130–230 mg/kg per day as a continuous intravenous infusion. Renal impairment usually develops within the first few weeks of treatment and is generally reversible within several weeks of discontinuing therapy. Foscarnet chelates metal ions, and serum electrolyte abnormalities – predominantly hypocalcemia, hypomagnesemia, hypokalemia and hypophosphatemia – occur in about 30, 15, 16 and 8% of patients, respectively. Convulsions occur in 10–15%. Other side effects include anemia (25–50%), penile or vulval ulceration (3–9%), nausea and vomiting (20–30%), local irritation and thrombophlebitis at the infusion site, abdominal pain and occasional pancreatitis, headache (c. 25%), dizziness, involuntary muscle contractions, tremor, hypoesthesia, ataxia, neuropathy, anxiety, nervousness, depression and confusion, and skin rash. Nephrogenic diabetes insipidus has been reported.
Foscarnet is contraindicated in pregnancy. Topical application does not result in dermal toxicity similar to that produced by phosphonacetic acid.

Phosphonoformic acid trisodium salt hexahydrate Preparation Products And Raw materials

Raw materials

Preparation Products

Foscarnet sodium

Less

Phosphonoformic acid trisodium salt hexahydrate Suppliers

Canada 2 China 116 Denmark 1 France 1 Germany 4 India 6 Switzerland 1 The Netherlands 1 United Kingdom 4 United States 27 Global 163

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94838
Advantage: 76

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30132
Advantage: 84

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44751
Advantage: 61

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15421
Advantage: 60

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 0712-0712-2580635 15527768850
Email: 1791901229@qq.com
Country: China
ProdList: 8849
Advantage: 52

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9823
Advantage: 79

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9664
Advantage: 60

Wuhan Fortuna Chemical Co., Ltd

Tel: 027-027-59207852 13308628970
Fax: QQ3130921841
Email: buy@fortunachem.com
Country: China
ProdList: 2893
Advantage: 58

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9901
Advantage: 58

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 18521732826;
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25015
Advantage: 65

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9552
Advantage: 55

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4428
Advantage: 55

Huainan Kedi Chemical Factory

Tel: 0554-2106669
Fax: 0554-2666215
Email: sales1@kedichem.com
Country: China
ProdList: 4928
Advantage: 55

Chengdu HuaXia Chemical Reagent Co. Ltd

Tel: 400-1166-196 13458535857
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 13358
Advantage: 58

Wuhan Dahua Pharmaceutical Co., Ltd.

Tel: 027-59262863 13277907145 3091977954
Fax: 027-59420980
Country: China
ProdList: 4951
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

Nanjing Chempioneer Pharmaceutical Co., Ltd.

Tel: 18068075658
Fax: -
Email: sales@chempioneer.com
Country: China
ProdList: 1811
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: 3429815786 13301662590
Fax: +86-21-51619052
Email: sales@atkchemical.com
Country: China
ProdList: 10006
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 27322
Advantage: 60

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9934
Advantage: 55

Shandong Xiya Chemical Co., Ltd.

Tel: 4009903999 13395398332
Fax: 0539-6365991
Email: sales@xiyashiji.com
Country: China
ProdList: 20810
Advantage: 60

Hubei widely chemical technology Co., Ltd.

Tel: 027-83991130 18627774460
Fax: 027-83991130
Email: 1718093273@QQ.COM
Country: China
ProdList: 1892
Advantage: 58

Taian Jiaye Biotechnology Co.Ltd

Tel: 13127280945
Email: 285424065@qq.com
Country: China
ProdList: 9980
Advantage: 55

Shanghai Orgchem Co.,Ltd.

Tel: +86-21-5877 1921
Fax: +86-21-5877 1925
Email: info@chemofchina.com
Country: China
ProdList: 9661
Advantage: 55

Shandong Ono Chemical Co., Ltd.

Tel: 0539-6362799 20）
Fax: 0539-6362799（To 20）
Country: China
ProdList: 10007
Advantage: 58

Wuhan Netcom Electronic Commerce Limited

Tel: 18064670521
Fax: 0757-88210752
Email: 2355935187@ycphar.com
Country: China
ProdList: 4887
Advantage: 58

Shanghai BaiShun Biological Technology Co., Ltd

Tel: 021-37581181
Fax: 021-57456066
Email: sales@chem-mall.com
Country: China
ProdList: 10335
Advantage: 58

Zhuhai JiaYi Biological Technology Co., Ltd.

Tel: 18578209868 2355327026
Fax: 18578209868 QQ：2355327026
Email: steroidbest@hotmail.com
Country: China
ProdList: 6504
Advantage: 58

Aikon International Limited

Tel: 025-66113011 13155353615
Fax: (7)02557626880
Email: qzhang@aikonchem.com
Country: China
ProdList: 15396
Advantage: 58

Wuhan FengyaoTonghui Chemical Products Co., Ltd.

Tel: 027-87466105 15377573527
Email: 2678564200@qq.com
Country: China
ProdList: 17997
Advantage: 58

Rhawn Reagent

Tel: 400-400-1332688 18019345275
Fax: 400-133-2688
Email: amy@rhawn.cn
Country: China
ProdList: 15503
Advantage: 58

Shanghai He Huan Chemical Co., Ltd.

Tel: 021-60345187 13917602471
Fax: 021-60345187
Email: lzz841106@aliyun.com
Country: China
ProdList: 9908
Advantage: 58

Shandong Chenxi Pharmaceutical Co., Ltd.

Tel: +86-0531-88803416 13153166250
Fax: 0531-88803416
Email: sales@chemedpharma.com
Country: China
ProdList: 248
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 24971
Advantage: 58

Hefei Yaogu Biological Technology Co., Ltd.

Tel: 0086-0551-62993905
Fax: 0086-0551-62993905
Email: info@hxygmall.com
Country: China
ProdList: 3374
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-0371-63315541 13323832564
Fax: QQ:3001332135
Email: 3001332135@qq.com
Country: China
ProdList: 9075
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 400-400-400-9004166 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52712
Advantage: 58

Beijing Minruida Technology Co., Ltd.

Tel: 010-82387566 18001021521;
Fax: 82387566-801
Email: sales@mreda.com.cn
Country: China
ProdList: 21450
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 13028896684
Email: sales@rrkchem.com
Country: China
ProdList: 55791
Advantage: 58

Macheng jinxin biotechnology co., LTD

Tel: 18271582018
Email: 1126319697@qq.com
Country: China
ProdList: 1536
Advantage: 58

Guangzhou TongYi biochemistry technology Co.,LTD

Tel: +8613073028829
Email: mack@tongyon.com
Country: China
ProdList: 2996
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: 571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: CHINA
ProdList: 52867
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: 0571-85134551
Fax: 008657185134895
Email: info@afinechem.com
Country: CHINA
ProdList: 15377
Advantage: 58

Wuhan Chemwonders Technology Inc.

Tel: 027-85778276
Fax: 027-85778276
Email: info@chemwonders.com
Country: CHINA
ProdList: 176
Advantage: 58

Hubei Chanmol Biotech Co., Ltd.

Tel: 0711-3812399 18062309155
Email: 156941107@qq.com
Country: China
ProdList: 2986
Advantage: 58

Xiamen AmoyChem Co., Ltd

Tel: +86-592-6051114 +8618959220845
Email: sales@amoychem.com
Country: China
ProdList: 6387
Advantage: 58

Hubei xin bonus chemical co. LTD

Tel: 86-13657291602
Fax: 027-59338440
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 22968
Advantage: 58

Shanghai Yanze Chemical Co., Ltd.

Tel: 021-13773155751 19975051755
Email: 260924549@qq.com
Country: China
ProdList: 8555
Advantage: 58

Chongqing Chemdad Co., Ltd

Tel: +86-023-61398051 +8613650506873
Email: sales@chemdad.com
Country: China
ProdList: 39916
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49390
Advantage: 58

Less

View Lastest Price from Phosphonoformic acid trisodium salt hexahydrate manufacturers

Henan Fengda Chemical Co., Ltd

Product: Phosphonoformic acid trisodium salt hexahydrate 34156-56-4
Price: US $32.00-1.10/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-22

Shaanxi Dideu Medichem Co. Ltd

Product: Phosphonoformic acid trisodium salt hexahydrate 34156-56-4
Price: US $1.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 Tons
Release date: 2020-01-14

Career Henan Chemical Co

Product: Phosphonoformic acid trisodium salt hexahydrate 34156-56-4
Price: US $7.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-18

34156-56-4, Phosphonoformic acid trisodium salt hexahydrateRelated Search:

Sodium formate FOSCARNET SODIUM, DELIVERED >= 97% PURE WITH HPLC UV CHROMATOGRAM FOSCARNET = DIHYDROXYPHOSPHINECARBOXYLIC ACID OXIDE TRISODIUM SALT FOSCARNET IMPURITY BDISODIUM(ETHOXYOXYDOPHOSPHANYL)FORMATE EPF(CRM STANDARD) FOSCARNET SODIUM BP STANDARD(CRM STANDARD) FOSCARNET SODIUM ASSAY STANDARD BP(CRM STANDARD) FOSCARNET SODIUM HEXAHYDRATE FOSCARNET IMPURITY B Foscarnet sodium FOSCARNET SODIUM HEXAHYDRATE EPF(CRM STANDARD) Phosphonoformic acid trisodium salt hexahydrate Foscarnet PhosphonoMethanol FOSCARNET SODIUM, [14C]-

Foscarnet, Phosphonoformic acid hexahydrate trisodium salt

Sodium phosphonoformate hexahydrate tribasic

trisodium phosphonatoformate hexahydrate

trisodium phosphonatomethanoate hexahydrate

Foscarnet Sodium (50 mg)

1,1-Dihydroxyphosphinecarboxylic Acid 1-Oxide SodiuM Salt Hydrate

A 29622 Hydrate

EHB 776 Hydrate

Foscavir Hydrate

Gefin Hydrate

PFA Hydrate

FOSCARNET TRISODIUM SALT HEXAHYDRATE

PhosphonoforMic Acid TrisodiuM Salt Hydrate

Triapten Hexahydrate

TRI-SODIUM PHOSPHONOFORMATE HEXAHYDRATE

dihydroxyphosphinecarboxylicacidoxidetrisodiumsalthexahydrate

phosphinecarboxylicacid,dihydroxy-,oxide,trisodiumsalt,hexahydrate

SODIUM PHOSPHONOFORMATE HEXAHYDRATE

SODIUM PHOSPHONOFORMATE TRIBASIC HEXAHYDRATE

PHOSPHONOFORMIC ACID TRISODIUM SALT HEXAHYDRATE

PHOSPHONOFORMIC ACID TRISODIUM*HEXAHYDRA TE

Sodiumphosphonoformate6H2O

Sodium phosphonatoformate hexahydrate

Foscarnet Sodium(PFA)

FORSCARNETSODIUM

Sodium phosphonoformate hexahydrate, 98+%

Foscarnet sodium hexahydrate CRS

Trisodium Phosphonoformate Hexahydrate Discontinued See: F727400

Sodium phosphonoformate 6-hydrate

trisodium hexahydrate phosphonatoformate

phosphonatoformate

Foscarnet Sodium (1283302)

Phosphonoformic acid trisodium salt hexa

Sodium dioxidophosphinecarboxylate oxide hydrate

Foscarnet (trisodium hexahydrate)

Phosphonoformic acid trisodium salt hexahydrate?New

Foscarnet Sodium (50 mg) (Phosphonoformic acid, trisodium salt, hexahydrate)

34156-56-4

3416-56-4

CNa3O5P82266H2O

CO5P3Na6H2O

CH12Na3O11P

CH3O5P6H2O3Na

Na2O3PCO2Na6H2O

CH12O11Na3P

Organic Building Blocks

Phosphorus Compounds

Phosphonic/Phosphinic Acid Salts

Building Blocks

Phosphonic/Phosphinic Acid Salts

Bioactive Small Molecules

Building Blocks

Cell Biology

Chemical Synthesis

Organic Building Blocks

Phosphorus Compounds

Intermediates & Fine Chemicals