Phosphonoformic acid trisodium salt hexahydrate

ChemicalBook > CAS DataBase List > Phosphonoformic acid trisodium salt hexahydrate

Phosphonoformic acid trisodium salt hexahydrate

Product Name: Phosphonoformic acid trisodium salt hexahydrate
CAS No.: 34156-56-4
Chemical Name: Phosphonoformic acid trisodium salt hexahydrate
Synonyms: PFA Hydrate;Gefin Hydrate;EHB 776 Hydrate;A 29622 Hydrate;Foscavir Hydrate;FORSCARNETSODIUM;phosphonatoformate;Triapten Hexahydrate;Foscarnet Sodium(PFA);Foscarnet Sodium (50 mg)
CBNumber: CB3714429
Molecular Formula: CH6NaO6P
Formula Weight: 168.02
MOL File: 34156-56-4.mol

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Phosphonoformic acid trisodium salt hexahydrate Property

storage temp.: 2-8°C
solubility: H₂O: 0.1 g/mL hot, clear, colorless
form: Solid
color: White to off-white
Water Solubility: Soluble in water.
InChIKey: ILRVASBWNRYBFD-UHFFFAOYSA-K
CAS DataBase Reference: 34156-56-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: SY8300000
HS Code: 29319090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H341Suspected of causing genetic defects

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P6801
Product name: Sodium phosphonoformate tribasic hexahydrate
Packaging: 1g
Price: $94.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: BP623
Product name: Foscarnet sodium
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 100MG
Price: $269
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1283302
Product name: Foscarnet sodium
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 50mg
Price: $436
Updated: 2024/03/01

Alfa Aesar

Product number: B24784
Product name: Sodium phosphonoformate hexahydrate, 98+%
Packaging: 1g
Price: $92.65
Updated: 2024/03/01

Alfa Aesar

Product number: B24784
Product name: Sodium phosphonoformate hexahydrate, 98+%
Packaging: 5g
Price: $297.65
Updated: 2024/03/01

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Phosphonoformic acid trisodium salt hexahydrate Chemical Properties,Usage,Production

Chemical Properties

Phosphonoformic acid trisodium salt hexahydrate is white or almost white, crystalline powder.

Uses

Sodium phosphonoformate hexahydrate acts as an antiviral agent and reverse transcriptase inhibitor. It is also used to inhibit viral DNA polymerase. Further, it is used as a type II Pi transporter inhibitor.

Uses

Foscarnet inhibits viral DNA polymerase and reverse transcriptase. Foscarnet is used as an antiviral.

Definition

ChEBI: The hexahydrate form of trisodium phosphonoformate. It is used as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patien s who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.

Acquired resistance

Phosphonoformic acid trisodium salt hexahydrate can be generated in vitro, and CMV strains resistant to both ganciclovir and foscarnet have occasionally been recovered from humans.

Pharmaceutical Applications

Phosphonoformic acid trisodium salt hexahydrate is a synthetic non-nucleoside pyrophosphate analog formulated as the trisodium hexahydrate for intravenous use. The solubility in water at pH 7 is only about 5% (w/w).

Pharmacokinetics

Oral absorption: c. 17%
C_max 60 mg/kg intravenous 8-hourly: 557 μmol/L
Plasma half-life: 3.3–6.8 h
Volume of distribution: 0.52–0.74 L/kg
Plasma protein binding: 14–17%
Absorption and distribution
Oral bioavailability is poor. A wide range of plasma concentrations was noted (75–500 μmol/L) during 3–21 days of continuous intravenous infusion of 0.14–0.19 mg/kg per min. During continuous intravenous therapy the concentrations reached a plateau on day 3. Considerable differences in steady-state plasma concentrations exist between individuals. Drug penetrates the CSF; the mean concentration is about 40–60% of the mean plasma concentration, depending upon dose.
Metabolism and excretion
Elimination appears to be triphasic, with two initially short half-lives of 0.5–1.4 h and 3.3–6.8 h, followed by a long terminal phase of 88 h. About 88% of the cumulative intravenous dose is recovered unchanged in the urine within a week of stopping an infusion, indicating that the drug is not significantly metabolized. Non-renal clearance accounts for 14–18% of total clearance and may relate to uptake into bone. Plasma clearance decreases markedly with decreased renal function and the elimination half-life may be increased by up to 10-fold. Conventional dialysis eliminates about 25% of a dose while high-flux dialysis can remove nearly 60%.

Clinical Use

Treatment of CMV retinitis in patients for whom ganciclovir is contraindicated, inappropriate or ineffective
It is also potentially of value in the treatment of aciclovir-resistant HSV infection.

Side effects

Treatment is more frequently limited by toxicity than with ganciclovir. Renal toxicity is most common. A two- to three-fold increase in serum creatinine levels occurs in 20–60% (mean 45%) of patients given 130–230 mg/kg per day as a continuous intravenous infusion. Renal impairment usually develops within the first few weeks of treatment and is generally reversible within several weeks of discontinuing therapy. Foscarnet chelates metal ions, and serum electrolyte abnormalities – predominantly hypocalcemia, hypomagnesemia, hypokalemia and hypophosphatemia – occur in about 30, 15, 16 and 8% of patients, respectively. Convulsions occur in 10–15%. Other side effects include anemia (25–50%), penile or vulval ulceration (3–9%), nausea and vomiting (20–30%), local irritation and thrombophlebitis at the infusion site, abdominal pain and occasional pancreatitis, headache (c. 25%), dizziness, involuntary muscle contractions, tremor, hypoesthesia, ataxia, neuropathy, anxiety, nervousness, depression and confusion, and skin rash. Nephrogenic diabetes insipidus has been reported.
Foscarnet is contraindicated in pregnancy. Topical application does not result in dermal toxicity similar to that produced by phosphonacetic acid.

Phosphonoformic acid trisodium salt hexahydrate Preparation Products And Raw materials

Raw materials

Preparation Products

Foscarnet sodium

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Phosphonoformic acid trisodium salt hexahydrate Suppliers

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View Lastest Price from Phosphonoformic acid trisodium salt hexahydrate manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Phosphonoformic acid trisodium salt hexahydrate 34156-56-4
Price: US $1.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 Tons
Release date: 2020-01-14

Henan Fengda Chemical Co., Ltd

Product: Phosphonoformic acid trisodium salt hexahydrate 34156-56-4
Price: US $32.00-1.10/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-22

Career Henan Chemical Co

Product: Phosphonoformic acid trisodium salt hexahydrate 34156-56-4
Price: US $7.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-18

34156-56-4, Phosphonoformic acid trisodium salt hexahydrateRelated Search:

Sodium formate FOSCARNET SODIUM, DELIVERED >= 97% PURE WITH HPLC UV CHROMATOGRAM FOSCARNET = DIHYDROXYPHOSPHINECARBOXYLIC ACID OXIDE TRISODIUM SALT FOSCARNET IMPURITY BDISODIUM(ETHOXYOXYDOPHOSPHANYL)FORMATE EPF(CRM STANDARD) FOSCARNET SODIUM BP STANDARD(CRM STANDARD) FOSCARNET SODIUM ASSAY STANDARD BP(CRM STANDARD) FOSCARNET SODIUM HEXAHYDRATE FOSCARNET IMPURITY B Foscarnet sodium FOSCARNET SODIUM HEXAHYDRATE EPF(CRM STANDARD) Phosphonoformic acid trisodium salt hexahydrate Foscarnet PhosphonoMethanol FOSCARNET SODIUM, [14C]-

Foscarnet, Phosphonoformic acid hexahydrate trisodium salt

Sodium phosphonoformate hexahydrate tribasic

trisodium phosphonatoformate hexahydrate

trisodium phosphonatomethanoate hexahydrate

Foscarnet Sodium (50 mg)

1,1-Dihydroxyphosphinecarboxylic Acid 1-Oxide SodiuM Salt Hydrate

A 29622 Hydrate

EHB 776 Hydrate

Foscavir Hydrate

Gefin Hydrate

PFA Hydrate

FOSCARNET TRISODIUM SALT HEXAHYDRATE

PhosphonoforMic Acid TrisodiuM Salt Hydrate

Triapten Hexahydrate

TRI-SODIUM PHOSPHONOFORMATE HEXAHYDRATE

dihydroxyphosphinecarboxylicacidoxidetrisodiumsalthexahydrate

phosphinecarboxylicacid,dihydroxy-,oxide,trisodiumsalt,hexahydrate

SODIUM PHOSPHONOFORMATE HEXAHYDRATE

SODIUM PHOSPHONOFORMATE TRIBASIC HEXAHYDRATE

PHOSPHONOFORMIC ACID TRISODIUM SALT HEXAHYDRATE

PHOSPHONOFORMIC ACID TRISODIUM*HEXAHYDRA TE

Sodiumphosphonoformate6H2O

Sodium phosphonatoformate hexahydrate

Foscarnet Sodium(PFA)

FORSCARNETSODIUM

Sodium phosphonoformate hexahydrate, 98+%

Foscarnet sodium hexahydrate CRS

Trisodium Phosphonoformate Hexahydrate Discontinued See: F727400

Sodium phosphonoformate 6-hydrate

trisodium hexahydrate phosphonatoformate

phosphonatoformate

Foscarnet Sodium (1283302)

Phosphonoformic acid trisodium salt hexa

Sodium dioxidophosphinecarboxylate oxide hydrate

Foscarnet (trisodium hexahydrate)

Phosphonoformic acid trisodium salt hexahydrate?New

Foscarnet Sodium (50 mg) (Phosphonoformic acid, trisodium salt, hexahydrate)

34156-56-4

3416-56-4

CNa3O5P82266H2O

CO5P3Na6H2O

CH12Na3O11P

CH3O5P6H2O3Na

Na2O3PCO2Na6H2O

CH12O11Na3P

Organic Building Blocks

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Phosphonic/Phosphinic Acid Salts

Building Blocks

Phosphonic/Phosphinic Acid Salts

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Intermediates & Fine Chemicals