2,2,6,6-Tetramethyl-4-piperidone hydrochloride Property

Melting point:

198 °C (dec.)(lit.)

storage temp. 

Sealed in dry,Room Temperature

form 

powder

color 

White to off-white

BRN 

4154554

LogP

1.323 (est)

CAS DataBase Reference

33973-59-0(CAS DataBase Reference)

EPA Substance Registry System

4-Piperidinone, 2,2,6,6-tetramethyl-, hydrochloride (33973-59-0)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-24/25

WGK Germany 

3

F 

8

Hazard Note 

Irritant

HS Code 

2933399990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

2,2,6,6-Tetramethyl-4-piperidone hydrochloride Chemical Properties,Usage,Production

Chemical Properties

white to slightly beige crystalline powder

Uses

2,2,6,6-Tetramethyl-4-piperidone hydrochloride has been used as a reagent injected in the micromixer using a Rheodyne injection valve for introducing discrete sample pulses into the miniaturised-SYNthesis and Total Analysis System (πSYNTAS).

Purification Methods

Purify the salt by recrystallisation from EtOH/Et2O, MeCN or Me2CO/MeOH. The free base has m 37-39o (after sublimation), b 102-105o/18mm, and the hydrate has m 56-58o (wet Et2O); the hydrobromide has m 203o (from EtOH/Et2O), and the picrate has m 196o (from aqueous EtOH). [Sandris & Ourisson Bull Soc Chim Fr 345 1958, Beilstein 21 H 246, 21 I 273, 21 II 222, 21 III/IV 3278, 21/6 V 538.]