ChemicalBook > CAS DataBase List > D-Leucine methyl ester hydrochloride

D-Leucine methyl ester hydrochloride

Product Name: D-Leucine methyl ester hydrochloride
CAS No.: 5845-53-4
Chemical Name: D-Leucine methyl ester hydrochloride
Synonyms: eu-OMe·HCL;H-D-Leu-OMe;H-D-LEU-OME HCL;D-LEUCINE-OME HCL;N-METHYL-D-LEUCINE HCL;D-leucinate hydrochloride.;METHYL D-LEUCINATE HYDROCHLORIDE;D-leucine Methy ester hydrochloride;D-LEUCINE METHYL ESTER HYDROCHLORIDE;D-LeucineMethylEsterHydrochloride>
CBNumber: CB3721335
Molecular Formula: C7H16ClNO2
Formula Weight: 181.66
MOL File: 5845-53-4.mol

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D-Leucine methyl ester hydrochloride Property

Melting point:: 150 °C
alpha: -13.5 º (c=5, H2O)
refractive index: -14 ° (C=2, H2O)
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
color: Off-white to white
Water Solubility: soluble
Sensitive: Hygroscopic
InChI: InChI=1/C7H15NO2.ClH/c1-5(2)4-6(8)7(9)10-3;/h5-6H,4,8H2,1-3H3;1H/t6-;/s3
InChIKey: DODCBMODXGJOKD-FYZOBXCZSA-N
SMILES: [C@@H](N)(CC(C)C)C(=O)OC.Cl |&1:0,r|
CAS DataBase Reference: 5845-53-4(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
HS Code: 29224999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H372Causes damage to organs through prolonged or repeated exposure

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: L0198
Product name: D-Leucine Methyl Ester Hydrochloride
Purity: >98.0%(N)(T)
Packaging: 1g
Price: $32
Updated: 2025/07/31

TCI Chemical

Product number: L0198
Product name: D-Leucine Methyl Ester Hydrochloride
Purity: >98.0%(N)(T)
Packaging: 5g
Price: $106
Updated: 2025/07/31

Usbiological

Product number: 237188
Product name: D-Leucine methyl ester hydrochloride
Packaging: 1g
Price: $169
Updated: 2021/12/16

Usbiological

Product number: 281369
Product name: D-Leucine methyl ester hydrochloride
Packaging: 5g
Price: $475
Updated: 2021/12/16

Chem-Impex

Product number: 03094
Product name: D-Leucinemethylesterhydrochloride,99%(HPLC)
Purity: 99%(HPLC)
Packaging: 1G
Price: $11.2
Updated: 2021/12/16

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D-Leucine methyl ester hydrochloride Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Uses

D-Leucine methyl ester hydrochloride is a protected form of D-Leucine (L330150). D-Leucine is an unnatural isomer of L-Leucine (L330110) that acts as an auto-inhibitor of lactic streptococci in culture. D-Leucine causes analgesia in humans and also exhibits inhibitory activity in bacterial cell cultures.

Synthesis

67-56-1

328-38-1

5845-53-4

The general procedure for the synthesis of methyl (R)-2-amino-4-methylpentanoate hydrochloride from methanol and D-leucine was as follows: according to the method of SG Davies, HJ Sanganee, P. Szolcsányi in Tetrahedron 55 (1999) 3337, the procedure was as follows: D-leucine (60.24 mmol) was was suspended in anhydrous methanol (100 mL) and cooled to 0°C in an ice/salt bath. Thionyl chloride (SOCl2, 5.1 mL, 70.24 mmol) was added slowly and dropwise over 30 min. After removing the cooling bath, the reaction mixture was warmed to room temperature and stirred for 4 hours. Subsequently, the reaction mixture was concentrated under reduced pressure. The resulting white product was suspended in dichloromethane (DCM, 3 x 100 mL) and the solvent was removed by distillation under reduced pressure, a process repeated three times. The white crystalline compound was suspended in ethyl acetate (100 mL), filtered and the solid was washed with ethyl acetate (3 x 20 mL). The white product was dried to constant weight to give white powdered (R)-2-amino-4-methylpentanoic acid methyl ester hydrochloride in 92% yield. The product was characterized as follows: white solid; 92% yield; melting point 149.8-151.5 °C; [αD20] = -12.9° (c 1 , H2O).IR (ATR): 2957, 2921, 2842, 2632, 1731, 1588, 1506, 1451, 1248, 1225, 1040 cm-1.1H NMR ( 400 MHz, D2O): δ 4.10 (1H, t, J = 8 Hz, NH-CH-CH2- CH-(CH3)2), 3.79 (3H, s, O-CH3), 1.85-1.75 (1H, m, NH-CH-CH2- CH-(CH3)2), 1.75-1.62 (2H, m, NH-CH-CH2-CH -(CH3)2, NH-CH-CH2-CH-(CH3)2), 0.96-0.87 (6H, m, CH3-CH-CH3).13C NMR (100.79 MHz, D2O): δ 171.5, 53.6, 51.6, 38.9, 24.1, 21.6, 21.1.Elemental analysis: of C7H15N3O2 Calculated values (181.66): C, 46.28; H, 8.88; N, 7.71; Measured values: C, 45.99±0.03; H, 8.74±0.02; N, 7.69±0.02. HRMS: m/z Calculated values for C7H15N3O2: 146.11756 [M + H]+; Measured values: 146.11762 [M + H H]+.

References

[1] Angewandte Chemie - International Edition, 2016, vol. 55, # 34, p. 10113 - 10117
[2] Angew. Chem., 2016, vol. 128, p. 10267 - 10271,5
[3] Synlett, 2009, # 15, p. 2487 - 2491
[4] Liebigs Annalen der Chemie, 1985, vol. 1985, # 11, p. 2285 - 2300
[5] European Journal of Medicinal Chemistry, 2017, vol. 135, p. 142 - 158

D-Leucine methyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from D-Leucine methyl ester hydrochloride manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: D-Leu-Ome.Hcl 5845-53-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-03-26

Career Henan Chemical Co

Product: D-Leucine methyl ester hydrochloride 5845-53-4
Price: US $2.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100g , 1kg, 5kg , 50kg
Release date: 2020-01-07

5845-53-4, D-Leucine methyl ester hydrochlorideRelated Search:

H-D-LEU-OET HCL Bensulfuron methyl Topotecan hydrochloride L-tert-Leucine N-CARBOBENZOXY-DL-LEUCINE Kresoxim-methyl Methylparaben L-Alanine methyl ester hydrochloride Methyl acrylate H-D-LEU-NH2 HCL H-D-LEU-OBZL P-TOSYLATE H-D-Leu-OBzl H-D-LEU-OTBU HCL Methyl Methyl bromide (S,S)-2-Azabicyclo[3,3,0]-octane-3-carboxylic acid benzylester hydrochloride L-tert-Leucine methyl ester hydrochloride Methyl L-isoleucinate hydrochloride

N-METHYL-D-LEUCINE HCL

METHYL D-LEUCINATE HYDROCHLORIDE

H-D-LEU-OME HCL

D-LEUCINE METHYL ESTER HYDROCHLORIDE

D-LEUCINE METHYL ESTER HYDROCHLORIDE SALT

D-LEUCINE-OME HCL

(R)-2-Amino-4-methyl-pentanoic acid methyl ester hydrochloride

Methyl D-Leucinate Hydrochloride,99%e.e.

D-leucinate hydrochloride.

D-Leucine methyl ester hydrochloride,98%

(R)-Methyl 2-aMino-4-Methylpentanoate hydrochloride

D-leucine Methy ester hydrochloride

H-D-Leu-OMe

2-amino-4-methylpentanoic acid methyl ester hydrochloride

eu-OMe·HCL

methyl (2R)-2-amino-4-methylpentanoate hydrochloride

D-LeucineMethylEsterHydrochloride&gt

D-Leucine methyl ester hydrochloride USP/EP/BP

methyl (2R)-2-amino-4-methylpentanoate

D-Leucine, methyl ester, hydrochloride (1:1)

Methyl D-leucinate hydrochloride (1:1)

5845-53-4

Peptide Synthesis

N-Methyl Amino Acids

Specialty Synthesis

Unnatural Amino Acid Derivatives

Amino Acids

Amino Acid Methyl Esters

Amino Acids (C-Protected)

Biochemistry

Amino hydrochloride