Methyl L-isoleucinate hydrochloride

Product Name: Methyl L-isoleucinate hydrochloride
CAS No.: 18598-74-8
Chemical Name: Methyl L-isoleucinate hydrochloride
Synonyms: ILE-OMEHCL;H-lle-OMe.HCl;H-ILE-OME HCL;L-Ile-OMe.HCL;D-Ile-OMe·HCl;H-L-ILE-OME HCL;ISOLEUCINE-OME HCL;H-Ile-Ome x HCl ,≥99%;H-Ile-Ome hydrochloride;D-Isoleucine Methyl Ester HCl
CBNumber: CB9317411
Molecular Formula: C7H16ClNO2
Formula Weight: 181.66
MOL File: 18598-74-8.mol

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Methyl L-isoleucinate hydrochloride Property

Melting point:: 98-100 °C
alpha: 27 º (c=2% in H2O)
refractive index: 26.5 ° (C=2, H2O)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Soluble in methanol (50 mg/ml clear, colorless solution).
form: Powder or Crystalline Powder
color: Off-white to orange
optical activity: [α]20/D +27.0±1°, c = 2% in H2O
Sensitive: Hygroscopic
BRN: 3595132
Stability:: Hygroscopic
InChI: InChI=1/C7H15NO2.ClH/c1-4-5(2)6(8)7(9)10-3;/h5-6H,4,8H2,1-3H3;1H/t5-,6-;/s3
InChIKey: GGTBEWGOPAFTTH-ATPDZTHWNA-N
SMILES: [C@@H](N)(C(=O)OC)[C@@H](C)CC.Cl |&1:0,6,r|
CAS DataBase Reference: 18598-74-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-40
Safety Statements: 26-36/37/39-36-22-24/25
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29224999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 58920
Product name: L-Isoleucine methyl ester hydrochloride
Purity: ≥98.0% (AT)
Packaging: 5G
Price: $91.8
Updated: 2023/06/20

TCI Chemical

Product number: I0522
Product name: L-Isoleucine Methyl Ester Hydrochloride
Purity: >98.0%(T)
Packaging: 1g
Price: $16
Updated: 2025/07/31

TCI Chemical

Product number: I0522
Product name: L-Isoleucine Methyl Ester Hydrochloride
Purity: >98.0%(T)
Packaging: 5g
Price: $36
Updated: 2025/07/31

TRC

Product number: I820180
Product name: L-Isoleucine Methyl Ester Hydrochloride
Packaging: 1g
Price: $110
Updated: 2021/12/16

Usbiological

Product number: 239301
Product name: L-Isoleucine methyl ester hydrochloride
Packaging: 5g
Price: $163
Updated: 2021/12/16

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Methyl L-isoleucinate hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Crystalline

Uses

L-Isoleucine methyl ester used for chemical synthesis. E.g. It can also be used to produce 3-methyl-2-(4-nitro-imidazol-1-yl)-pentanoic acid methyl ester. It also finds its use as a pharmaceutical intermediate.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

67-56-1

73-32-5

18598-74-8

Under ice bath conditions, 1 mL of sulfuryl chloride (SOCl2) was added slowly and dropwise to 5 mL of cooled methanol and the reaction mixture was stirred for 30 minutes. Subsequently, 1.01 g (8.55 mmol) of L-isoleucine was added to the mixture and the reaction was continued with stirring overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The resulting residue was purified by fast column chromatography with an eluent ratio of methanol/ether = 1/5 (v/v), resulting in the colorless oily crystalline product L-isoleucine methyl ester hydrochloride in 98.8% yield. The spectral data of the product were consistent with those reported in the literature.

References

[1] Organic and Biomolecular Chemistry, 2017, vol. 15, # 44, p. 9372 - 9378
[2] Angewandte Chemie, 1992, vol. 104, # 1, p. 97 - 99
[3] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 8, p. 2747 - 2761
[4] Bulletin des Societes Chimiques Belges, 1991, vol. 100, # 1, p. 63 - 77
[5] Angewandte Chemie - International Edition, 2018, vol. 57, # 36, p. 11683 - 11687

Methyl L-isoleucinate hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl L-isoleucinate hydrochloride Suppliers

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View Lastest Price from Methyl L-isoleucinate hydrochloride manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: H-L-Ile-OMeHCl 18598-74-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-03-24

Henan Aochuang Chemical Co.,Ltd.

Product: Methyl L-isoleucinate hydrochloride 18598-74-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-09

Career Henan Chemical Co

Product: Methyl L-isoleucinate hydrochloride 18598-74-8
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: Customized
Release date: 2018-12-22

18598-74-8, Methyl L-isoleucinate hydrochlorideRelated Search:

Methylparaben Kresoxim-methyl Pyridine hydrochloride D-Glucosamine hydrochloride Methoxyammonium chloride L-Alanine methyl ester hydrochloride L-Isoleucine Triethylamine hydrochloride Methyl acrylate Bensulfuron methyl Topotecan hydrochloride Thiophanate-methyl Methyl H-ILE-NH2 HCL H-ILE-GLY-OH L-Isoleucine benzyl ester 4-toluenesulphonate L-Isoleucine allyl ester p-toluenesulfonate salt L-Isoleucine tert-butyl ester hydrochloride

ISOLEUCINE-OME HCL

H-ILE-OME HCL

H-L-ILE-OME HCL

L-ISOLEUCINE METHYL ESTER HYDROCHLORIDE

L-ISOLEUCINE METHYL ESTER HYDROCHLORIDE SALT

methyl L-isoleucinate hydrochloride

L-Isoleucine Methyl Ester HCl

D-Isoleucine Methyl Ester HCl

L-Isoleucine methyl ester hydrochloride, 98+%

H-lle-OMe.HCl

H-Ile-Ome hydrochloride

ILE-OMEHCL

L-Isoleucine methyl·hydrochloric acid

L-Ile-OMe.HCL

H-Ile-Ome x HCl ,≥99%

L-lsoleucine methyl ester hydrochloride

(2S)-Methyl 2-aMino-3-Methylpentanoate hydrochloride

Methyl (2S,3S)-2-aMino-3-Methylpentanoate hydrochloride

L-Isoleucine methyl ester hydrochloride >=98.0% (AT)

D-Ile-OMe·HCl

(2S,3S)-Methyl 2-amino-3-methylpentanoate hydrochloride

Methyl L-isoleucite hydrochloride

Methyl L-Isoleucinate Hydrochloride,99%e.e.

L-Isoleucine methyleester hydrochloride

(2S,3S)-Methyl 2-aMino-3-MethylPENTANOATE.HCL

L-Isoleucine, methylester, hydrochloride (1:1)

L-IsoleucineMethylEsterHydrochloride&gt

METHYL L-ISOLEUCINATE HYDROCHLORIDE (18598-74-8)

Methyl L-isoleucinate hydrochloride USP/EP/BP

L-Isoleucine methyl ester hydrochloride, 95%

<sc>L</sc>-Isoleucine methyl ester hydrochloride

18598-74-8

18568-74-8

CH3CH2CHCH3CHNH2COOCH3HCl

C7H14NO2HCl

AMINE

Amino Acid Derivatives

Specialty Synthesis

Peptide Synthesis

Amino Acids (C-Protected)

Amino Acid Methyl Esters

Protected & Labeled Amino Acids

Amino Acids

Amino Acid Derivatives

Isoleucine [Ile, I]

Amino Acids and Derivatives

Amino Acid Methyl Esters

Amino Acids (C-Protected)

Biochemistry

Amino ester

Amino hydrochloride

Peptide Synthesis

Amino Acid Derivatives

Amino Acids

I - ZPeptide Synthesis

Modified Amino Acids

bc0001