ChemicalBook > CAS DataBase List > MS1943

MS1943

Product Name
MS1943
CAS No.
2225938-17-8
Chemical Name
MS1943
Synonyms
MS1943;MS1943, 10 mM in DMSO;1,6-Dimethyl-2-aminomethyl-3-benzyloxypyridin-4(1H)-one;MS 1943,degrader,Histone Methyltransferase,breast,Apoptosis,inhibit,triple-negative,proliferation,methyltransferase,MS1943,cancer,Inhibitor,cytotoxic,MS-1943,TNBC;6-(6-(4-(2-(2-(Adamantan-1-yl)acetamido)ethyl)piperazin-1-yl)pyridin-3-yl)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-1H-indazole-4-carboxamide;1H-Indazole-4-carboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-[4-[2-[(2-tricyclo[3.3.1.13,7]dec-1-ylacetyl)amino]ethyl]-1-piperazinyl]-3-pyridinyl]-
CBNumber
CB37243678
Molecular Formula
C42H54N8O3
Formula Weight
718.93
MOL File
2225938-17-8.mol
More
Less

MS1943 Property

Density 
1.36±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in DMSO:100.0(Max Conc. mg/mL);139.1(Max Conc. mM)
form 
A solid
pka
12.56±0.46(Predicted)
color 
Light yellow to yellow
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

ChemScene
Product number
CS-0112146
Product name
MS1943
Purity
98.18%
Packaging
5mg
Price
$770
Updated
2021/12/16
ChemScene
Product number
CS-0112146
Product name
MS1943
Purity
98.18%
Packaging
10mg
Price
$1300
Updated
2021/12/16
ChemScene
Product number
CS-0112146
Product name
MS1943
Purity
98.18%
Packaging
50mg
Price
$3900
Updated
2021/12/16
ChemScene
Product number
CS-0112146
Product name
MS1943
Purity
98.18%
Packaging
100mg
Price
$5300
Updated
2021/12/16
DC Chemicals
Product number
DC26169
Product name
MS1943
Packaging
250mg
Price
$1300
Updated
2021/12/16
More
Less

MS1943 Chemical Properties,Usage,Production

Uses

MS1943 is used in the preparation of heterocyclic compounds as EZH2 ligands and their compositions and methods for treating EZH2-mediated cancer. MS1943 itself significantly reduces EZH2 protein levels in numerous triple-negative breast cancer

Biological Activity

MS1943 is a potent and selective degrader of EZH2 (enhancer of zeste homolog 2) th at effectively reduces EZH2 levels in cells. MS1943 potently inhibits growth of multiple TNBC cells and in mice xenograft model.

in vivo

MS1943 (150 mg/kg body weight; i.p.; once daily for 36 days) suppresses tumor growth[1].
MS1943 induces apoptosis in the MDA-MB-468 xenograft model[1].
A single i.p. injection of MS1943 at 50 mg/kg body weight achieved a peak plasma concentration (Cmax) of 2.9 μM and resulted in plasma concentrations above its cellular IC50 value for ~2h. A single 150 mg/kg body weight p.o. dose achieved Cmax of 1.1 μM, but plasma concentrations were below the cellular IC50 value[1].

Animal Model:Eight-week-old female BALB/c nude mice (MDA-MB-468 xenografts)[1]
Dosage:150 mg/kg body weight
Administration:i.p.; once daily for 36 days
Result:Suppresses tumor growth.

IC 50

EZH2 methyltransferase: 120 nM (IC50)

MS1943 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

MS1943 Suppliers

China 42 United States 3 Global 45
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7787
Advantage
56
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71829
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
17754423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
Advantage
62
Jilin Province Woda Biotechnology Co., Ltd.
Tel
13504435624
Email
1927928688@qq.com
Country
China
ProdList
1591
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32159
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9409
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Guangzhou Younan Technology Co., Ltd
Tel
020-82000279 18988968278
Fax
QQ：3283937693
Email
sales@ubiochem.com
Country
China
ProdList
4291
Advantage
58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd
Tel
15317229551
Fax
QQ:3607245178
Email
15151849396@163.com
Country
China
ProdList
998
Advantage
58

2225938-17-8, MS1943Related Search:

1H-Isoindole-1,3(2H)-dione, 4-[[2-[4-[6-[(6-acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]-2-oxoethyl]amino]-2-(2,6-dioxo-3-piperidinyl)- MS4078 MS4077

  • MS1943
  • 1,6-Dimethyl-2-aminomethyl-3-benzyloxypyridin-4(1H)-one
  • 1H-Indazole-4-carboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-[4-[2-[(2-tricyclo[3.3.1.13,7]dec-1-ylacetyl)amino]ethyl]-1-piperazinyl]-3-pyridinyl]-
  • 6-(6-(4-(2-(2-(Adamantan-1-yl)acetamido)ethyl)piperazin-1-yl)pyridin-3-yl)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-1H-indazole-4-carboxamide
  • MS 1943,degrader,Histone Methyltransferase,breast,Apoptosis,inhibit,triple-negative,proliferation,methyltransferase,MS1943,cancer,Inhibitor,cytotoxic,MS-1943,TNBC
  • MS1943, 10 mM in DMSO
  • 2225938-17-8
  • C42H54N8O3