1-BENZYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID
- Product Name
- 1-BENZYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID
- CAS No.
- 5733-86-8
- Chemical Name
- 1-BENZYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID
- Synonyms
- AKOS BB-9373;AURORA 17719;BUTTPARK 17\07-15;IFLAB-BB F1799-0573;TIMTEC-BB SBB011410;OTAVA-BB BB7018611176;1-Benzyl-5-oxopyrrolidine...;1-Benzyl-4-carboxy-2-pyrrolidone;1-Benzyl-4-carboxy-2-pyrrolidinone;1-benzyl-5-oxo-3-pyrrolidinecarboxylicaci
- CBNumber
- CB3726244
- Molecular Formula
- C12H13NO3
- Formula Weight
- 219.24
- MOL File
- 5733-86-8.mol
1-BENZYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID Property
- Melting point:
- 142.0 to 146.0 °C
- Boiling point:
- 471.3±45.0 °C(Predicted)
- Density
- 1.314±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 4.51±0.20(Predicted)
- color
- White to Almost white
- CAS DataBase Reference
- 5733-86-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- RTECS
- UY0686500
- HazardClass
- IRRITANT
- HS Code
- 2933790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H320Causes eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B4264
- Product name
- 1-Benzyl-5-oxopyrrolidine-3-carboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $159
- Updated
- 2022/04/27
- Product number
- B521445
- Product name
- 1-Benzyl-5-oxopyrrolidine-3-carboxylic Acid
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 008263
- Product name
- 1-Benzyl-5-oxo-pyrrolidine-3-carboxylic acid
- Packaging
- 1g
- Price
- $39
- Updated
- 2021/12/16
- Product number
- FB112131
- Product name
- 1-Benzyl-5-oxopyrrolidine-3-carboxylic acid
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- OR6330
- Product name
- 1-Benzyl-5-oxopyrrolidine-3-carboxylic Acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $109
- Updated
- 2021/12/16
1-BENZYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
51535-00-3
5733-86-8
Methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate (2.00 g, 8.57 mmol) was used as a raw material and dissolved in a mixed solvent of methanol (10 mL) and tetrahydrofuran (10 mL). Subsequently, 2 N aqueous lithium hydroxide (8.6 mL) was added to this solution. The reaction mixture was heated to reflux for 20 minutes. Upon completion of the reaction, the reaction solution was cooled in an ice bath, adjusted to acidity with aqueous potassium bisulfate, and then extracted with ethyl acetate. The organic layers were combined, concentrated and purified by repurification (ethyl acetate/hexane) and dried to give 1-benzyl-5-oxo-3-pyrrolidinecarboxylic acid (1.83 g, 97% yield).1H-NMR (DMSO-d6) δ: 2.56 (2H, m), 3.80 (1H, m), 3.15 (2H, m), 3.25 (2H, m), 4.36 (2H , q, J = 8.6 Hz), 7.27 (5H, m), 12.61 (1H, s).
References
[1] Patent: EP1403255, 2004, A1. Location in patent: Page 78
[2] Journal of Medicinal Chemistry, 1997, vol. 40, # 15, p. 2374 - 2385
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 1, p. 377 - 379
[4] European Journal of Organic Chemistry, 2005, # 4, p. 673 - 682
[5] Patent: WO2006/123725, 2006, A1. Location in patent: Page/Page column 64-65
1-BENZYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-BENZYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID manufacturers
- Product
- 4-(2-METHYL-IMIDAZOL-1-YL)-BENZALDEHYDE 5733-86-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2020-03-05