TOFISOPAM

Product Name: TOFISOPAM
CAS No.: 22345-47-7
Chemical Name: TOFISOPAM
Synonyms: SERIEL;Tosopam;EGYT 341;TOFISOPAM;tofizopam;grandaxin;Tofisopam, >=99%;TOFISOPAM 22345-47-7;Tofisopam, 10 mM in DMSO;7-CHLORO-1-METHYL-5-PHENYL-1,5-BENZODIAZEPINE-2,4-DIONE
CBNumber: CB3738807
Molecular Formula: C22H26N2O4
Formula Weight: 382.45
MOL File: 22345-47-7.mol

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TOFISOPAM Property

Melting point:: 155-159°C
Boiling point:: 509.61°C (rough estimate)
Density: 1.2098 (rough estimate)
refractive index: 1.6500 (estimate)
solubility: DMSO: ~14 mg/mL
form: solid
pka: 7.29±0.40(Predicted)
color: white
λmax: 310nm(MeOH)(lit.)
Merck: 14,9503
Stability:: Hygroscopic
InChI: 1S/C22H26N2O4/c1-7-15-13(2)23-24-22(14-8-9-18(25-3)19(10-14)26-4)17-12-21(28-6)20(27-5)11-16(15)17/h8-12,15H,7H2,1-6H3
InChIKey: RUJBDQSFYCKFAA-UHFFFAOYSA-N
SMILES: CCC1C(C)=NN=C(c2ccc(OC)c(OC)c2)c3cc(OC)c(OC)cc13

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-50
Safety Statements: 60-61
RIDADR: UN 3077 9/PG 3
WGK Germany: 2
RTECS: DE9540000
HS Code: 2933.99.8290
HazardClass: 6.1(b)
PackingGroup: III
Storage Class: 11 - Combustible Solids
Hazard Classifications: Acute Tox. 4 Oral
Aquatic Acute 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T8200
Product name: Tofisopam
Purity: ≥98% (HPLC), solid
Packaging: 10mg
Price: $181
Updated: 2025/07/31

Sigma-Aldrich

Product number: T8200
Product name: Tofisopam
Purity: ≥98% (HPLC), solid
Packaging: 50mg
Price: $574
Updated: 2025/07/31

TCI Chemical

Product number: T3509
Product name: Tofisopam
Purity: >98.0%(HPLC)
Packaging: 50mg
Price: $80
Updated: 2025/07/31

TCI Chemical

Product number: T3509
Product name: Tofisopam
Purity: >98.0%(HPLC)
Packaging: 250mg
Price: $240
Updated: 2025/07/31

Cayman Chemical

Product number: 22026
Product name: Tofisopam
Purity: ≥95%
Packaging: 1mg
Price: $73
Updated: 2024/03/01

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TOFISOPAM Chemical Properties,Usage,Production

Originator

Grandaxine,Ozothine,France,1975

Uses

Tofisopam is a reagent used in preparation of allosteric ligands for pharmacological dark receptors GPR68 and GPR65. An anticonvulsant.

Definition

ChEBI: Tofisopam is an organic molecular entity.

Manufacturing Process

A mixture of 38.6 g (0.1 mol) of 3,4,3',4'-tetramethoxy-6-(α-acetopropyl)- benzophenone, 5.5 g (0.11 mol) of 100% hydrazine hydrate or 3.52 g (0.11 mol) of hydrazine, and 500 ml of absolute ethanol is boiled for 5 hours. After adding 100 ml of benzene, 400 ml of solvent mixture is distilled off from the reaction mixture by slow boiling for 3 hours. After cooling for 8 hours, 19 g of 5H-2,3-benzodiazepine derivative are separated from the residue as small, white crystals. The melting point is 133°C to 136°C (after recrystallizing from absolute ethanol, 136°C)

Therapeutic Function

Tranquilizer

Biological Activity

Studies have reported th at tofisopam functions by blocking PDE4 (phosphodiesterase 4). Furthermore, the S-enantiomer of tofisopam is considered ten times more active than R-enantiomer.', 'Ligand for the GABAA receptor benzodiazepine modulatory site.

TOFISOPAM Preparation Products And Raw materials

Raw materials

Preparation Products

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TOFISOPAM Suppliers

China 85 Germany 2 India 9 Italy 1 Japan 2 Switzerland 1 United Kingdom 2 United States 10 USA 1 Global 113

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
Advantage: 55

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28387
Advantage: 80

UHN Shanghai Research & Development Co., Ltd.

Tel: 021-58958002 18930822973
Fax: +86 (21) 5895-8628
Email: sales@uhnshanghai.com
Country: China
ProdList: 998
Advantage: 58

Hangzhou Maicke Pharmaceutical Technology Co., Ltd.

Tel: 189-05714267
Fax: +86 (571) 8796-4501
Email: maicke@maicke.com
Country: China
ProdList: 16
Advantage: 60

China Nobel Chem Co., Limited

Tel: +86(0)21 60484900
Fax: +86(0)21 60484900
Country: China
ProdList: 764
Advantage: 50

Wuxi Zhangkun Biochemical Technology Co., Ltd.

Tel: +86 0510-85629785
Fax: +86 0510-85625359
Country: China
ProdList: 2327
Advantage: 58

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View Lastest Price from TOFISOPAM manufacturers

Shijiazhuang tongyang Import and Export Co., LTD

Product: TOFISOPAM 22345-47-7
Price: US $10.00/KG
Min. Order: 1g
Purity: 99
Supply Ability: 100kg/kg
Release date: 2021-08-10

Cangzhou Wanyou New Material Technology Co.,Ltd

Product: TOFISOPAM 22345-47-7 22345-47-7
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 300 Ton/Tons per Month china raw material pharmaceutical Tofisopam
Release date: 2019-04-22

Career Henan Chemical Co

Product: TOFISOPAM 22345-47-7
Price: US $14.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 50KG
Release date: 2018-07-23

22345-47-7, TOFISOPAMRelated Search:

3-[2-(3,4-dimethoxybenzoyl)-4,5-dimethoxyphenyl]pentan-2-one Toffee-related impurities (S)-Tofisopam (R)-Tofisopam ACETONE AZINE Acetophenone, 3-hydroxy-, hydrazone (6CI,7CI,8CI) TOFISOPAM

TOFISOPAM

7,8-DIMETHOXY-1-(3,4-DIMETHOXYPHENYL)-5-ETHYL-4-METHYL-5H-2,3-BENZODIAZEPINE

1-(3,4-Dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-benzo[d][1,2]diazepine

Tosopam

TOFISOPAM 22345-47-7

1-(3,4-Dimethoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine

5H-2,3-Benzodiazepine, 1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl- (8CI, 9CI)

tofizopam

7-CHLORO-1-METHYL-5-PHENYL-1,5-BENZODIAZEPINE-2,4-DIONE

EGYT 341, Seriel, 7,8-Dimethoxy-1-(3,4-dimethoxyphenyl)-5-ethyl-4-methyl-5H-2,3-benzodiazepine

EGYT 341

1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5h-2,3-benzodiazepine

1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5h-3-benzodiazepine

grandaxin

Tofisopam, >=99%

-5-ethyl-7,8-dimethoxy-4-methyl-5H-benzo[d][1,2]diazepine

SERIEL

1-[3,4-Bis(methyloxy)phenyl]-5-ethyl-4-methyl-7,8-bis(methyloxy)-5H-2,3-benzodiazepine

1-(3,4-DiMethoxyphenyl)-5-ethyl-7,8-diMethoxy-4-Methyl-5H-2,3-benzodiazepine (TofisopaM)

5H-2,3-Benzodiazepine, 1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-

TofisopamQ: What is Tofisopam Q: What is the CAS Number of Tofisopam Q: What is the storage condition of Tofisopam Q: What are the applications of Tofisopam

Tofisopam, 10 mM in DMSO

22345-47-7

C22H26N2O4