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TOFISOPAM

Product Name
TOFISOPAM
CAS No.
22345-47-7
Chemical Name
TOFISOPAM
Synonyms
SERIEL;Tosopam;EGYT 341;TOFISOPAM;tofizopam;grandaxin;Tofisopam, >=99%;TOFISOPAM 22345-47-7;7-CHLORO-1-METHYL-5-PHENYL-1,5-BENZODIAZEPINE-2,4-DIONE;-5-ethyl-7,8-dimethoxy-4-methyl-5H-benzo[d][1,2]diazepine
CBNumber
CB3738807
Molecular Formula
C22H26N2O4
Formula Weight
382.45
MOL File
22345-47-7.mol
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TOFISOPAM Property

Melting point:
155-159°C
Boiling point:
509.61°C (rough estimate)
Density 
1.2098 (rough estimate)
refractive index 
1.6500 (estimate)
solubility 
DMSO: ~14 mg/mL
form 
solid
pka
7.29±0.40(Predicted)
color 
white
λmax
310nm(MeOH)(lit.)
Merck 
14,9503
Stability:
Hygroscopic
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Safety

Hazard Codes 
Xn,N
Risk Statements 
22-50
Safety Statements 
60-61
RIDADR 
UN 3077 9/PG 3
WGK Germany 
2
RTECS 
DE9540000
HS Code 
2933.99.8290
HazardClass 
6.1(b)
PackingGroup 
III
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T8200
Product name
Tofisopam
Purity
≥98% (HPLC), solid
Packaging
10mg
Price
$176
Updated
2024/03/01
Sigma-Aldrich
Product number
T8200
Product name
Tofisopam
Purity
≥98% (HPLC), solid
Packaging
50mg
Price
$558
Updated
2024/03/01
TCI Chemical
Product number
T3509
Product name
Tofisopam
Purity
>98.0%(HPLC)
Packaging
50mg
Price
$84
Updated
2024/03/01
TCI Chemical
Product number
T3509
Product name
Tofisopam
Purity
>98.0%(HPLC)
Packaging
250mg
Price
$253
Updated
2024/03/01
Cayman Chemical
Product number
22026
Product name
Tofisopam
Purity
≥95%
Packaging
1mg
Price
$73
Updated
2024/03/01
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TOFISOPAM Chemical Properties,Usage,Production

Originator

Grandaxine,Ozothine,France,1975

Uses

Tofisopam is a reagent used in preparation of allosteric ligands for pharmacological dark receptors GPR68 and GPR65. An anticonvulsant.

Definition

ChEBI: Tofisopam is an organic molecular entity.

Manufacturing Process

A mixture of 38.6 g (0.1 mol) of 3,4,3',4'-tetramethoxy-6-(α-acetopropyl)- benzophenone, 5.5 g (0.11 mol) of 100% hydrazine hydrate or 3.52 g (0.11 mol) of hydrazine, and 500 ml of absolute ethanol is boiled for 5 hours. After adding 100 ml of benzene, 400 ml of solvent mixture is distilled off from the reaction mixture by slow boiling for 3 hours. After cooling for 8 hours, 19 g of 5H-2,3-benzodiazepine derivative are separated from the residue as small, white crystals. The melting point is 133°C to 136°C (after recrystallizing from absolute ethanol, 136°C)

Therapeutic Function

Tranquilizer

TOFISOPAM Preparation Products And Raw materials

Raw materials

Preparation Products

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TOFISOPAM Suppliers

China 80 Germany 2 India 9 Italy 1 Japan 2 Switzerland 1 United Kingdom 2 United States 10 USA 1 Global 108
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View Lastest Price from TOFISOPAM manufacturers

Shijiazhuang tongyang Import and Export Co., LTD
Product
TOFISOPAM 22345-47-7
Price
US $10.00/KG
Min. Order
1g
Purity
99
Supply Ability
100kg/kg
Release date
2021-08-10
Cangzhou Wanyou New Material Technology Co.,Ltd
Product
TOFISOPAM 22345-47-7 22345-47-7
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
300 Ton/Tons per Month china raw material pharmaceutical Tofisopam
Release date
2019-04-22
Career Henan Chemical Co
Product
TOFISOPAM 22345-47-7
Price
US $14.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
50KG
Release date
2018-07-23

22345-47-7, TOFISOPAMRelated Search:

3-[2-(3,4-dimethoxybenzoyl)-4,5-dimethoxyphenyl]pentan-2-one Toffee-related impurities (S)-Tofisopam (R)-Tofisopam ACETONE AZINE Acetophenone, 3-hydroxy-, hydrazone (6CI,7CI,8CI) TOFISOPAM

  • TOFISOPAM
  • 7,8-DIMETHOXY-1-(3,4-DIMETHOXYPHENYL)-5-ETHYL-4-METHYL-5H-2,3-BENZODIAZEPINE
  • 1-(3,4-Dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-benzo[d][1,2]diazepine
  • Tosopam
  • TOFISOPAM 22345-47-7
  • 1-(3,4-Dimethoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine
  • 5H-2,3-Benzodiazepine, 1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl- (8CI, 9CI)
  • tofizopam
  • 7-CHLORO-1-METHYL-5-PHENYL-1,5-BENZODIAZEPINE-2,4-DIONE
  • EGYT 341, Seriel, 7,8-Dimethoxy-1-(3,4-dimethoxyphenyl)-5-ethyl-4-methyl-5H-2,3-benzodiazepine
  • EGYT 341
  • 1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5h-2,3-benzodiazepine
  • 1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5h-3-benzodiazepine
  • grandaxin
  • Tofisopam, >=99%
  • -5-ethyl-7,8-dimethoxy-4-methyl-5H-benzo[d][1,2]diazepine
  • SERIEL
  • 1-[3,4-Bis(methyloxy)phenyl]-5-ethyl-4-methyl-7,8-bis(methyloxy)-5H-2,3-benzodiazepine
  • 1-(3,4-DiMethoxyphenyl)-5-ethyl-7,8-diMethoxy-4-Methyl-5H-2,3-benzodiazepine (TofisopaM)
  • 5H-2,3-Benzodiazepine, 1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-
  • TofisopamQ: What is Tofisopam Q: What is the CAS Number of Tofisopam Q: What is the storage condition of Tofisopam Q: What are the applications of Tofisopam
  • 22345-47-7
  • C22H26N2O4