ChemicalBook > CAS DataBase List > TOFISOPAM

TOFISOPAM

Product Name
TOFISOPAM
CAS No.
22345-47-7
Chemical Name
TOFISOPAM
Synonyms
SERIEL;Tosopam;EGYT 341;TOFISOPAM;tofizopam;grandaxin;Tofisopam, >=99%;TOFISOPAM 22345-47-7;7-CHLORO-1-METHYL-5-PHENYL-1,5-BENZODIAZEPINE-2,4-DIONE;-5-ethyl-7,8-dimethoxy-4-methyl-5H-benzo[d][1,2]diazepine
CBNumber
CB3738807
Molecular Formula
C22H26N2O4
Formula Weight
382.45
MOL File
22345-47-7.mol
More
Less

TOFISOPAM Property

Melting point:
155-159°C
Boiling point:
509.61°C (rough estimate)
Density 
1.2098 (rough estimate)
refractive index 
1.6500 (estimate)
solubility 
DMSO: ~14 mg/mL
form 
solid
pka
7.29±0.40(Predicted)
color 
white
λmax
310nm(MeOH)(lit.)
Merck 
14,9503
Stability:
Hygroscopic
More
Less

Safety

Hazard Codes 
Xn,N
Risk Statements 
22-50
Safety Statements 
60-61
RIDADR 
UN 3077 9/PG 3
WGK Germany 
2
RTECS 
DE9540000
HS Code 
2933.99.8290
HazardClass 
6.1(b)
PackingGroup 
III
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T8200
Product name
Tofisopam
Purity
≥98% (HPLC), solid
Packaging
10mg
Price
$176
Updated
2024/03/01
Sigma-Aldrich
Product number
T8200
Product name
Tofisopam
Purity
≥98% (HPLC), solid
Packaging
50mg
Price
$558
Updated
2024/03/01
TCI Chemical
Product number
T3509
Product name
Tofisopam
Purity
>98.0%(HPLC)
Packaging
50mg
Price
$84
Updated
2024/03/01
TCI Chemical
Product number
T3509
Product name
Tofisopam
Purity
>98.0%(HPLC)
Packaging
250mg
Price
$253
Updated
2024/03/01
Cayman Chemical
Product number
22026
Product name
Tofisopam
Purity
≥95%
Packaging
1mg
Price
$73
Updated
2024/03/01
More
Less

TOFISOPAM Chemical Properties,Usage,Production

Originator

Grandaxine,Ozothine,France,1975

Uses

Tofisopam is a reagent used in preparation of allosteric ligands for pharmacological dark receptors GPR68 and GPR65. An anticonvulsant.

Definition

ChEBI: Tofisopam is an organic molecular entity.

Manufacturing Process

A mixture of 38.6 g (0.1 mol) of 3,4,3',4'-tetramethoxy-6-(α-acetopropyl)- benzophenone, 5.5 g (0.11 mol) of 100% hydrazine hydrate or 3.52 g (0.11 mol) of hydrazine, and 500 ml of absolute ethanol is boiled for 5 hours. After adding 100 ml of benzene, 400 ml of solvent mixture is distilled off from the reaction mixture by slow boiling for 3 hours. After cooling for 8 hours, 19 g of 5H-2,3-benzodiazepine derivative are separated from the residue as small, white crystals. The melting point is 133°C to 136°C (after recrystallizing from absolute ethanol, 136°C)

Therapeutic Function

Tranquilizer

TOFISOPAM Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

TOFISOPAM Suppliers

China 79 Germany 2 India 9 Italy 1 Japan 2 Switzerland 1 United Kingdom 2 United States 10 USA 1 Global 107
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1493
Advantage
55
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
UHN Shanghai Research & Development Co., Ltd.
Tel
021-58958002 18930822973
Fax
+86 (21) 5895-8628
Email
SALES@UHNSHANGHAI.COM
Country
China
ProdList
977
Advantage
58
Hangzhou Maicke Pharmaceutical Technology Co., Ltd.
Tel
189-05714267
Fax
+86 (571) 8796-4501
Email
maicke@maicke.com
Country
China
ProdList
16
Advantage
60
China Nobel Chem Co., Limited
Tel
+86(0)21 60484900
Fax
+86(0)21 60484900
Country
China
ProdList
764
Advantage
50
Wuxi Zhangkun Biochemical Technology Co., Ltd.
Tel
+86 0510-85629785
Fax
+86 0510-85625359
Country
China
ProdList
2327
Advantage
58
Beijin Yangguang Furui Chemical co.,Ltd.
Tel
010-57495520 13521095525
Email
zhw512@foxmail.com
Country
China
ProdList
488
Advantage
55
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-+86-571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
11481
Advantage
59
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9484
Advantage
50
Struchem Co., Ltd.
Tel
0512-0512-63009836 15365350169
Fax
0512-63006936
Email
helen@struchem.com
Country
China
ProdList
3984
Advantage
60
Chemwill Asia Co.,Ltd.
Tel
86-21-51086038
Fax
86-21-51861608
Email
sales@chemwill.com
Country
China
ProdList
1974
Advantage
58
ATK CHEMICAL COMPANY LIMITED
Tel
021-51619050 13301662590
Fax
+86-21-51619052
Email
mandy@atkchemical.com
Country
China
ProdList
8026
Advantage
55
Shanghai Changyan Chem & Tech Co., Ltd.
Tel
021-20242659 18930833303
Fax
+86 (21) 2024-2659
Email
Sales@changyanchem.cn
Country
China
ProdList
5010
Advantage
55
Lancrix Chemicals
Tel
86-21-50817262
Fax
86-21-57712035
Email
sales@lancrix.com
Country
China
ProdList
1502
Advantage
55
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Aikon International Limited
Tel
025-58851090 13611564524
Fax
(6)02557626880
Email
lwan@aikonchem.com
Country
China
ProdList
15951
Advantage
58
Henan Alfachem Co.,Ltd.
Tel
0371-0371-55051623 18137891487
Fax
QQ：2853979817
Email
2853979817@qq.com
Country
China
ProdList
9881
Advantage
58
3A Chemicals
Tel
400-668-9898
Fax
010-51582189
Email
service@3achem.com
Country
China
ProdList
20557
Advantage
58
Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3251
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52693
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
TCI Chemicals
Tel
021-67121386, 800-988-0390
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
5391
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418671 +8618949823763
Fax
0551-65418697
Email
sales@tnjchem.com
Country
China
ProdList
34553
Advantage
58
Shijiazhuang Tongyang Import and Export Co., LTD
Tel
18031361688;
Email
admin@sjztongyang.com
Country
China
ProdList
977
Advantage
58
AFINE CHEMICALS LIMITED
Tel
+86-0571-85134551
Fax
008657185134895
Email
sales@afinechem.com
Country
China
ProdList
15354
Advantage
58
SIMAGCHEM CORP
Tel
+86-13806087780
Email
sale@simagchem.com
Country
China
ProdList
17365
Advantage
58
Chemwill Asia Co.,Ltd.
Tel
86-21-51086038
Fax
86-21-51861608
Email
chemwill_asia@126.com
Country
CHINA
ProdList
23912
Advantage
58
Cangzhou Wanyou New Material Technology Co.,Ltd
Tel
18631714998
Email
sales@czwytech.com
Country
CHINA
ProdList
904
Advantage
58
Wuxi Kehua Biological Technology Co., Ltd.
Tel
0510-0510-86838766
Email
2258830676@qq.com
Country
China
ProdList
4546
Advantage
58
Chongqing Chemdad Co., Ltd
Tel
+86-023-6139-8061 +86-86-13650506873
Email
sales@chemdad.com
Country
China
ProdList
39894
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49374
Advantage
58
Shanghai Wangyu Biotechnology Co., Ltd.
Tel
021-59501308 18321645636
Email
chengjinwang2005@163.com
Country
China
ProdList
96
Advantage
58
Wuxi Minglu Medicine technology Co.,Ltd.
Tel
0510-88726693
Fax
0510-88726693
Email
3204601684@qq.com
Country
China
ProdList
2215
Advantage
58
Wuxi Helen Biotechnology Co., Ltd.,
Tel
0510-85629785 18013409632
Fax
0510-85625359
Email
sales@reading-chemicals.com
Country
China
ProdList
14081
Advantage
58
CHG Opto-Electronic Corporation Limited
Tel
2537653158 16621191650
Fax
QQ 2537653158
Email
2537653158@qq.com
Country
China
ProdList
6884
Advantage
58
Shanghai Botuo Biotechnology Co., LTD
Tel
16621358918
Fax
QQ:402135374
Email
botuopharma888@163.com
Country
China
ProdList
9208
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Wuhan Topule
Tel
+86-02787215551 +86-19945035818
Fax
027-87215551
Email
2936752263@qq.com
Country
China
ProdList
7973
Advantage
58
Zhengzhou Akem Chemical Co., Ltd
Tel
13303867194
Email
3001317055@qq.com
Country
China
ProdList
9990
Advantage
58
Guangzhou Yunmen Biotechnology Co., Ltd
Tel
18902340307 18902340307
Fax
0751-2819901
Email
3356812514@qq.com
Country
China
ProdList
9245
Advantage
58
JinOu Biomedical (Nanjing) Co., Ltd.
Tel
13000000000
Fax
jinoupharma@163
Email
jinoupharma@163.com
Country
China
ProdList
11721
Advantage
58
Hubei Kele Fine Chemical Co., Ltd
Tel
027-59101668 19945030958
Fax
027-59101668
Email
2881924765@qq.com
Country
China
ProdList
8140
Advantage
58
Wuhan Augda Biotechnology Co., Ltd
Tel
15071299552
Fax
QQ:262933239
Email
262933239@qq.com
Country
China
ProdList
6883
Advantage
58
InvivoChem
Tel
13549236410
Email
sales@invivochem.cn
Country
China
ProdList
6753
Advantage
58
Changzhou Bojia Biomedical Technology Co., Ltd.
Tel
2122619822
Email
czbjpharma@126.com
Country
China
ProdList
18478
Advantage
58
More
Less

View Lastest Price from TOFISOPAM manufacturers

Shijiazhuang tongyang Import and Export Co., LTD
Product
TOFISOPAM 22345-47-7
Price
US $10.00/KG
Min. Order
1g
Purity
99
Supply Ability
100kg/kg
Release date
2021-08-10
Cangzhou Wanyou New Material Technology Co.,Ltd
Product
TOFISOPAM 22345-47-7 22345-47-7
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
300 Ton/Tons per Month china raw material pharmaceutical Tofisopam
Release date
2019-04-22
Career Henan Chemical Co
Product
TOFISOPAM 22345-47-7
Price
US $14.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
50KG
Release date
2018-07-23

22345-47-7, TOFISOPAMRelated Search:

3-[2-(3,4-dimethoxybenzoyl)-4,5-dimethoxyphenyl]pentan-2-one Toffee-related impurities (S)-Tofisopam (R)-Tofisopam ACETONE AZINE Acetophenone, 3-hydroxy-, hydrazone (6CI,7CI,8CI) TOFISOPAM

  • TOFISOPAM
  • 7,8-DIMETHOXY-1-(3,4-DIMETHOXYPHENYL)-5-ETHYL-4-METHYL-5H-2,3-BENZODIAZEPINE
  • 1-(3,4-Dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-benzo[d][1,2]diazepine
  • Tosopam
  • TOFISOPAM 22345-47-7
  • 1-(3,4-Dimethoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine
  • 5H-2,3-Benzodiazepine, 1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl- (8CI, 9CI)
  • tofizopam
  • 7-CHLORO-1-METHYL-5-PHENYL-1,5-BENZODIAZEPINE-2,4-DIONE
  • EGYT 341, Seriel, 7,8-Dimethoxy-1-(3,4-dimethoxyphenyl)-5-ethyl-4-methyl-5H-2,3-benzodiazepine
  • EGYT 341
  • 1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5h-2,3-benzodiazepine
  • 1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5h-3-benzodiazepine
  • grandaxin
  • Tofisopam, >=99%
  • -5-ethyl-7,8-dimethoxy-4-methyl-5H-benzo[d][1,2]diazepine
  • SERIEL
  • 1-[3,4-Bis(methyloxy)phenyl]-5-ethyl-4-methyl-7,8-bis(methyloxy)-5H-2,3-benzodiazepine
  • 1-(3,4-DiMethoxyphenyl)-5-ethyl-7,8-diMethoxy-4-Methyl-5H-2,3-benzodiazepine (TofisopaM)
  • 5H-2,3-Benzodiazepine, 1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-
  • TofisopamQ: What is Tofisopam Q: What is the CAS Number of Tofisopam Q: What is the storage condition of Tofisopam Q: What are the applications of Tofisopam
  • 22345-47-7
  • C22H26N2O4