ChemicalBook > CAS DataBase List > 2-(4-CHLOROPHENOXY)ANILINE

2-(4-CHLOROPHENOXY)ANILINE

Product Name
2-(4-CHLOROPHENOXY)ANILINE
CAS No.
2770-11-8
Chemical Name
2-(4-CHLOROPHENOXY)ANILINE
Synonyms
Amoxapine RC 4;Amoxapine Impurity 2;2-(4-CHLOROPHENOXY)ANILINE;2-(4'-CHLOROPHENOXY)ANILINE;2-(4-chlorophenoxy)benzenamine;2-Amino-4'-chlorodiphenyl Ether;[2-(4-chlorophenoxy)phenyl]amine;Benzenamine, 2-(4-chlorophenoxy)-;2-Amino-4'-chlorodiphenyl Ether >2-Amino-4'-chlorodiphenyl Ether, ≥ 98.0%
CBNumber
CB3739965
Molecular Formula
C12H10ClNO
Formula Weight
219.67
MOL File
2770-11-8.mol
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2-(4-CHLOROPHENOXY)ANILINE Property

Boiling point:
202°C/15mmHg(lit.)
Density 
1.260±0.06 g/cm3(Predicted)
refractive index 
1.6180-1.6220
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Chloroform (Sparingly), Methanol (Slightly)
form 
Oil
pka
3.69±0.10(Predicted)
color 
Colourless to Light Orange
CAS DataBase Reference
2770-11-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
HS Code 
2922290090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
A2223
Product name
2-Amino-4'-chlorodiphenyl Ether
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$185
Updated
2025/07/31
TRC
Product number
C374980
Product name
2-(4-Chlorophenoxy)aniline
Packaging
25g
Price
$990
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC20307
Product name
2-(4-Chlorophenoxy)aniline
Packaging
25g
Price
$1000
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC20307
Product name
2-(4-Chlorophenoxy)aniline
Packaging
1g
Price
$85
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC20307
Product name
2-(4-Chlorophenoxy)aniline
Packaging
10g
Price
$450
Updated
2021/12/16
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2-(4-CHLOROPHENOXY)ANILINE Chemical Properties,Usage,Production

Chemical Properties

pale yellow powder

Uses

Amoxapine impurity.

Synthesis

39145-47-6

2770-11-8

General procedure for the synthesis of 4'-chloro-2-amino-diphenyl ether from 1-(4-chlorophenoxy)-2-nitrobenzene: A mixture of commercially available iron powder (3.18 g, 57.28 mmol) and ammonium chloride (383 mg, 7.15 mmol) in ethanol (45 mL) and water (8 mL) was refluxed. To this mixture was added 1-(4-chlorophenoxy)-2-nitrobenzene (AMR01028,2.2 g, 8.81 mmol) and the resulting mixture was stirred at reflux for 1 hour. After completion of the reaction, the solvent was removed and the residue was diluted in aqueous sodium bicarbonate (40 mL) and extracted with dichloromethane (3 x 20 mL). The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and the solvent was evaporated to give 4'-chloro-2-amino-diphenyl ether (AMR01029,1.50 g, 78%) as a colorless oil, which could be used in the next step without further purification. Thin layer chromatography (TLC) Rf value was 0.53 (unfolding agent: dichloromethane).1H NMR (270MHz, CDCl3) data: δ 3.77 (2H, broad single peak, NH2), 6.71 (1H, multiple peaks), 6.83 (2H, multiple peaks), 6.89 (2H, AA'BB' system), 6.99 (1H, multiple peaks), 7.25 ( 2H, AA'BB' system).

References

[1] Patent: WO2007/3934, 2007, A2. Location in patent: Page/Page column 119
[2] Journal of the American Chemical Society, 2014, vol. 136, # 40, p. 14060 - 14067
[3] Journal of the Chemical Society, 1931, p. 529,533
[4] Journal of the Chemical Society, 1925, vol. 127, p. 2011
[5] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1976, p. 1279 - 1285

2-(4-CHLOROPHENOXY)ANILINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2770-11-8, 2-(4-CHLOROPHENOXY)ANILINERelated Search:

5-CHLORO-2-(4-CHLOROPHENOXY)ANILINE Loxapine succinate salt 2-(4-CHLOROPHENOXY)ANILINE 4-(4-CHLORO-3-METHYLPHENOXY)-3-NITROBENZOTRIFLUORIDE 2-(2,4-DICHLOROPHENOXY)ANILINE HYDROCHLORIDE 5-chloro-2-(2,4-dichlorophenoxy)aniline 2-(2,4-Dichlorophenoxy)aniline 1-[(4-Chlorophenyl)oxy]-2-nitrobenzene 4-Chloro-1-(4-chlorophenoxy)-2-nitrobenzene 2,4-DICHLORO-4'-AMINODIPHENYL ETHER 4-Amino-4'-chlorodiphenyl ether 2-(2-CHLOROPHENOXY)ANILINE 5-Chloro-2-(2-chlorophenoxy)aniline 2-(3-CHLOROPHENOXY)ANILINE 3-CHLORO-2-(3-CHLOROPHENOXY)ANILINE 4-Chlorodiphenyl ether Aniline 2-AMINO-4'-CHLORO-4-TRIFLUOROMETHYL DIPHENYL ETHER

  • 2-(4'-CHLOROPHENOXY)ANILINE
  • 2-(4-CHLOROPHENOXY)ANILINE
  • 2-(4-chlorophenoxy)benzenamine
  • [2-(4-chlorophenoxy)phenyl]amine
  • 2-Amino-4'-chlorodiphenyl Ether &gt
  • Amoxapine Impurity 2
  • Benzenamine, 2-(4-chlorophenoxy)-
  • Amoxapine RC 4
  • 2-Amino-4'-chlorodiphenyl Ether, ≥ 98.0%
  • 2-Amino-4'-chlorodiphenyl Ether
  • 2770-11-8
  • Amines
  • Impurities
  • Intermediates
  • Intermediates & Fine Chemicals
  • Pharmaceuticals