Loxapine succinate salt
- Product Name
- Loxapine succinate salt
- CAS No.
- 27833-64-3
- Chemical Name
- Loxapine succinate salt
- Synonyms
- S-805;loxapac;lederle;cl71563;SUM-317;Daxolin;loxitane;daxoline;CL-62362;SUM-3170
- CBNumber
- CB8709350
- Molecular Formula
- C22H24ClN3O5
- Formula Weight
- 445.9
- MOL File
- 27833-64-3.mol
Loxapine succinate salt Property
- Melting point:
- 150-152°C
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- H2O: soluble
- form
- solid
- color
- white
- CAS DataBase Reference
- 27833-64-3(CAS DataBase Reference)
Safety
- RIDADR
- UN 2811 6.1 / PGII
- WGK Germany
- 3
- RTECS
- WM5750000
- HS Code
- 29329990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- L106
- Product name
- Loxapine succinate salt
- Purity
- solid
- Packaging
- 100mg
- Price
- $67.5
- Updated
- 2024/03/01
- Product number
- 1370702
- Product name
- Loxapine succinate
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 125mg
- Price
- $358
- Updated
- 2024/03/01
- Product number
- 20760
- Product name
- Loxapine (succinate)
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 20760
- Product name
- Loxapine (succinate)
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $54
- Updated
- 2024/03/01
- Product number
- L106
- Product name
- Loxapine succinate salt
- Purity
- solid
- Packaging
- 500mg
- Price
- $273
- Updated
- 2023/06/20
Loxapine succinate salt Chemical Properties,Usage,Production
Description
Loxapine was first developed in the late 1960s and was introduced into clinical practice in the following decade. It is used primarily to treat the psychotic symptoms of schizophrenia. It is a member of the dibenzoxazepine class and is structurally related to clozapine. The introduction of newer antipsychotic agents has resulted in the reduced utilization of loxapine over the last few decades.
Description
Loxapine is an atypical antipsychotic drug that displays high affinity for histamine, 5-HT, dopamine, and α1-adrenergic receptors (Ki values are 7, 7.7, 9.5, 12, and 31 nM for H1, 5-HT2A, 5-HT2C, D2, and α1A, respectively). It reduces agitation associated with schizophrenia or bipolar disorder.
Chemical Properties
White to Of-White Solid
Uses
A D2/D4-Dopamine receptor antagonist. A serotonergic receptor antagonist. A dibenzoxazepine antipsychotic agent
Uses
choleretic
Uses
Loxapine is used to treat and control the psychotic symptoms of both acute and chronic schizophrenia. Other uses include treatment of dementia, anxiety neurosis, hostile/aggressive behavior, and psychotic depression. An inhalation powder of loxapine (Adasuve) was recently approved in the United States and the European Union for the acute management of agitation in patients with bipolar disorder or schizophrenia.
brand name
Loxapine (Mylan); Loxitane (Watson).
Toxicity evaluation
Loxapine has antagonistic action on alpha1 adrenergic, muscarinic, serotonergic, and dopaminergic receptors. It is thought to change the level of excitability in subcortical inhibitory areas of the brain by reducing the firing threshold of some polysynaptic neurons leading to seizure activity. Anticholinergic effects are also reported with loxapine intoxication.
Loxapine succinate salt Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Loxapine succinate salt manufacturers
- Product
- Loxapine succinate salt 27833-64-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Loxapine succinate salt 27833-64-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09