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Loxapine succinate salt

Product Name
Loxapine succinate salt
CAS No.
27833-64-3
Chemical Name
Loxapine succinate salt
Synonyms
S-805;loxapac;lederle;cl71563;SUM-317;Daxolin;loxitane;daxoline;CL-62362;SUM-3170
CBNumber
CB8709350
Molecular Formula
C22H24ClN3O5
Formula Weight
445.9
MOL File
27833-64-3.mol
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Loxapine succinate salt Property

Melting point:
150-152°C
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
H2O: soluble
form 
solid
color 
white
CAS DataBase Reference
27833-64-3(CAS DataBase Reference)
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Safety

RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
3
RTECS 
WM5750000
HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
L106
Product name
Loxapine succinate salt
Purity
solid
Packaging
100mg
Price
$67.5
Updated
2024/03/01
Sigma-Aldrich
Product number
1370702
Product name
Loxapine succinate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
125mg
Price
$358
Updated
2024/03/01
Cayman Chemical
Product number
20760
Product name
Loxapine (succinate)
Purity
≥98%
Packaging
50mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
20760
Product name
Loxapine (succinate)
Purity
≥98%
Packaging
100mg
Price
$54
Updated
2024/03/01
Sigma-Aldrich
Product number
L106
Product name
Loxapine succinate salt
Purity
solid
Packaging
500mg
Price
$273
Updated
2023/06/20
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Loxapine succinate salt Chemical Properties,Usage,Production

Description

Loxapine was first developed in the late 1960s and was introduced into clinical practice in the following decade. It is used primarily to treat the psychotic symptoms of schizophrenia. It is a member of the dibenzoxazepine class and is structurally related to clozapine. The introduction of newer antipsychotic agents has resulted in the reduced utilization of loxapine over the last few decades.

Description

Loxapine is an atypical antipsychotic drug that displays high affinity for histamine, 5-HT, dopamine, and α1-adrenergic receptors (Ki values are 7, 7.7, 9.5, 12, and 31 nM for H1, 5-HT2A, 5-HT2C, D2, and α1A, respectively). It reduces agitation associated with schizophrenia or bipolar disorder.

Chemical Properties

White to Of-White Solid

Uses

A D2/D4-Dopamine receptor antagonist. A serotonergic receptor antagonist. A dibenzoxazepine antipsychotic agent

Uses

choleretic

Uses

Loxapine is used to treat and control the psychotic symptoms of both acute and chronic schizophrenia. Other uses include treatment of dementia, anxiety neurosis, hostile/aggressive behavior, and psychotic depression. An inhalation powder of loxapine (Adasuve) was recently approved in the United States and the European Union for the acute management of agitation in patients with bipolar disorder or schizophrenia.

brand name

Loxapine (Mylan); Loxitane (Watson).

Toxicity evaluation

Loxapine has antagonistic action on alpha1 adrenergic, muscarinic, serotonergic, and dopaminergic receptors. It is thought to change the level of excitability in subcortical inhibitory areas of the brain by reducing the firing threshold of some polysynaptic neurons leading to seizure activity. Anticholinergic effects are also reported with loxapine intoxication.

Loxapine succinate salt Preparation Products And Raw materials

Raw materials

Preparation Products

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Loxapine succinate salt Suppliers

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View Lastest Price from Loxapine succinate salt manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Loxapine succinate salt 27833-64-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Loxapine succinate salt 27833-64-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

27833-64-3, Loxapine succinate saltRelated Search:

DIMETHYLTHEXYLSILYL CHLORIDE Vinylbenzyl chloride Epichlorohydrin 6alpha-Methylprednisolone sodium succinate ZINC ZIRCONATE 1-CHLOROMETHYL-1H-1,2,4-TRIAZOLE Ethyl 2-(Chlorosulfonyl)acetate Sodium chloride 1-Methylpiperazine Succinic anhydride Folic acid Dimethyl succinate Succinic acid Succimer Disodium succinate Hexamethyldisilazane tert-Butyldimethylsilyl chloride loxapine

  • cl71563
  • daxoline
  • lederle
  • loxapac
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  • succinicacid,compd.with2-chloro-11-(4-methyl-1-piperazinyl)dibenz(b,f)(1,4)oxazepine(1:1)
  • LIDOCAINE SUCCINATE
  • LOXAPINE SUCCINATE
  • LOXAPINE SUCCINATE SALT
  • 2-CHLORO-11-(4-METHYL-1-PIPERAZINYL)-DIBENZ[B,F][1,4]-OXAZEPINE SUCCINATE
  • succinic acid 2-chloro-11-(4-methylpiperazin-1-yl)dibenz[b,f][1,4]oxazepine salt
  • succinic acid, compound with 2-chloro-11-(4-methylpiperazin-1-yl)dibenz[b,f][1,4]oxazepine (1:1)
  • LOXAPINE SUCCINATE DIBENZOXAZEPINE ANTIP
  • 6,9-Dihydro-2-chloro-11-(4-methylpiperazino)dibenz[b,f][1,4]oxazepine
  • Loxapine succina
  • Loxapine Succinate (125 mg)
  • CL-62362
  • Oxilapine
  • S-805
  • SUM-317
  • LOXAPINESUCCINATE,USP
  • Loxapine Succinate Capsules
  • Loxapine succinate salt, USP 25 grade
  • SUM-3170
  • Loxapine succinate, >=98%
  • Butanedioic acid, compd. with 2-chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepine (1:1)
  • dopamine receptor
  • Lidocaine succinate, 98%, a 5-HT inhibitor
  • Calcium Carbonate Tablets
  • 8-chloro-6-(4-methyl-1-piperazin-1-iumylidene)-5H-benzo[b][1,4]benzoxazepine
  • Cloxazepin
  • Daxolin
  • Loxapine succinate salt USP/EP/BP
  • Loxapine Succinate saltQ: What is Loxapine Succinate salt Q: What is the CAS Number of Loxapine Succinate salt Q: What is the storage condition of Loxapine Succinate salt
  • Loxapine Succinate (1370702)
  • 27833-64-3
  • C18H18ClN3OC4H6O4
  • API
  • DILABIL
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