Loxapine succinate salt

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Loxapine succinate salt

Product Name: Loxapine succinate salt
CAS No.: 27833-64-3
Chemical Name: Loxapine succinate salt
Synonyms: S-805;loxapac;lederle;cl71563;SUM-317;Daxolin;loxitane;daxoline;CL-62362;SUM-3170
CBNumber: CB8709350
Molecular Formula: C22H24ClN3O5
Formula Weight: 445.9
MOL File: 27833-64-3.mol

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Loxapine succinate salt Property

Melting point:: 150-152°C
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: H₂O: soluble
form: solid
color: white
CAS DataBase Reference: 27833-64-3(CAS DataBase Reference)

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Safety

RIDADR: UN 2811 6.1 / PGII
WGK Germany: 3
RTECS: WM5750000
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: L106
Product name: Loxapine succinate salt
Purity: solid
Packaging: 100mg
Price: $67.5
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1370702
Product name: Loxapine succinate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 125mg
Price: $358
Updated: 2024/03/01

Cayman Chemical

Product number: 20760
Product name: Loxapine (succinate)
Purity: ≥98%
Packaging: 50mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 20760
Product name: Loxapine (succinate)
Purity: ≥98%
Packaging: 100mg
Price: $54
Updated: 2024/03/01

Sigma-Aldrich

Product number: L106
Product name: Loxapine succinate salt
Purity: solid
Packaging: 500mg
Price: $273
Updated: 2023/06/20

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Loxapine succinate salt Chemical Properties,Usage,Production

Description

Loxapine was first developed in the late 1960s and was introduced into clinical practice in the following decade. It is used primarily to treat the psychotic symptoms of schizophrenia. It is a member of the dibenzoxazepine class and is structurally related to clozapine. The introduction of newer antipsychotic agents has resulted in the reduced utilization of loxapine over the last few decades.

Description

Loxapine is an atypical antipsychotic drug that displays high affinity for histamine, 5-HT, dopamine, and α₁-adrenergic receptors (K_i values are 7, 7.7, 9.5, 12, and 31 nM for H₁, 5-HT_2A, 5-HT_2C, D₂, and α_1A, respectively). It reduces agitation associated with schizophrenia or bipolar disorder.

Chemical Properties

White to Of-White Solid

Uses

A D2/D4-Dopamine receptor antagonist. A serotonergic receptor antagonist. A dibenzoxazepine antipsychotic agent

Uses

choleretic

Uses

Loxapine is used to treat and control the psychotic symptoms of both acute and chronic schizophrenia. Other uses include treatment of dementia, anxiety neurosis, hostile/aggressive behavior, and psychotic depression. An inhalation powder of loxapine (Adasuve) was recently approved in the United States and the European Union for the acute management of agitation in patients with bipolar disorder or schizophrenia.

brand name

Loxapine (Mylan); Loxitane (Watson).

Toxicity evaluation

Loxapine has antagonistic action on alpha1 adrenergic, muscarinic, serotonergic, and dopaminergic receptors. It is thought to change the level of excitability in subcortical inhibitory areas of the brain by reducing the firing threshold of some polysynaptic neurons leading to seizure activity. Anticholinergic effects are also reported with loxapine intoxication.

Loxapine succinate salt Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Loxapine succinate salt manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Loxapine succinate salt 27833-64-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Loxapine succinate salt 27833-64-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

27833-64-3, Loxapine succinate saltRelated Search:

DIMETHYLTHEXYLSILYL CHLORIDE Vinylbenzyl chloride Epichlorohydrin 6alpha-Methylprednisolone sodium succinate ZINC ZIRCONATE 1-CHLOROMETHYL-1H-1,2,4-TRIAZOLE Ethyl 2-(Chlorosulfonyl)acetate Sodium chloride 1-Methylpiperazine Succinic anhydride Folic acid Dimethyl succinate Succinic acid Succimer Disodium succinate Hexamethyldisilazane tert-Butyldimethylsilyl chloride loxapine

cl71563

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lederle

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succinicacid,compd.with2-chloro-11-(4-methyl-1-piperazinyl)dibenz(b,f)(1,4)oxazepine(1:1)

LIDOCAINE SUCCINATE

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LOXAPINE SUCCINATE SALT

2-CHLORO-11-(4-METHYL-1-PIPERAZINYL)-DIBENZ[B,F][1,4]-OXAZEPINE SUCCINATE

succinic acid 2-chloro-11-(4-methylpiperazin-1-yl)dibenz[b,f][1,4]oxazepine salt

succinic acid, compound with 2-chloro-11-(4-methylpiperazin-1-yl)dibenz[b,f][1,4]oxazepine (1:1)

LOXAPINE SUCCINATE DIBENZOXAZEPINE ANTIP

6,9-Dihydro-2-chloro-11-(4-methylpiperazino)dibenz[b,f][1,4]oxazepine

Loxapine succina

Loxapine Succinate (125 mg)

CL-62362

Oxilapine

S-805

SUM-317

LOXAPINESUCCINATE,USP

Loxapine Succinate Capsules

Loxapine succinate salt, USP 25 grade

SUM-3170

Loxapine succinate, >=98%

Butanedioic acid, compd. with 2-chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepine (1:1)

dopamine receptor

Lidocaine succinate, 98%, a 5-HT inhibitor

Calcium Carbonate Tablets

8-chloro-6-(4-methyl-1-piperazin-1-iumylidene)-5H-benzo[b][1,4]benzoxazepine

Cloxazepin

Daxolin

Loxapine succinate salt USP/EP/BP

Loxapine Succinate saltQ: What is Loxapine Succinate salt Q: What is the CAS Number of Loxapine Succinate salt Q: What is the storage condition of Loxapine Succinate salt

Loxapine Succinate (1370702)

27833-64-3

C18H18ClN3OC4H6O4

API

DILABIL

neurochemistry

Intermediates & Fine Chemicals

Pharmaceuticals

Antagonists

Dopaminergics

Neurotransmitters