4-Amino-4'-chlorodiphenyl ether
- Product Name
- 4-Amino-4'-chlorodiphenyl ether
- CAS No.
- 101-79-1
- Chemical Name
- 4-Amino-4'-chlorodiphenyl ether
- Synonyms
- SALOR-INT L300845-1EA;Amoxapine Impurity 21;4-Chlorophenoxyaniline;p-(p-chlorophenoxy)-anilin;P-(P-CHLOROPHENOXY)ANILINE;4-(4-CHLOROPHENOXY)ANILINE;4-(p-Chlorophenoxy)aniline;4-(4'-CHLOROPHENOXY)ANILINE;4-(4-Chlorophenoxy)benzamide;4-(4-CHLOROPHENOXY)BENZENAMINE
- CBNumber
- CB8341082
- Molecular Formula
- C12H10ClNO
- Formula Weight
- 219.67
- MOL File
- 101-79-1.mol
4-Amino-4'-chlorodiphenyl ether Property
- Melting point:
- 99-103 °C
- Boiling point:
- 205 °C / 12mmHg
- Density
- 1.1764 (rough estimate)
- refractive index
- 1.6000 (estimate)
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated)
- pka
- 4.60±0.10(Predicted)
- form
- powder to crystal
- color
- White to Light yellow to Light orange
- Water Solubility
- Insoluble in water.
- CAS DataBase Reference
- 101-79-1(CAS DataBase Reference)
- EPA Substance Registry System
- Benzenamine, 4-(4-chlorophenoxy)- (101-79-1)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-40-43-41-37/38-22
- Safety Statements
- 26-36/37/39-36/37
- WGK Germany
- 3
- RTECS
- BX1770000
- TSCA
- Yes
- HazardClass
- IRRITANT
- HS Code
- 29222990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 695386
- Product name
- 4-(4-Chlorophenoxy)aniline
- Purity
- 97%
- Packaging
- 5g
- Price
- $88.7
- Updated
- 2023/06/20
- Product number
- 695386
- Product name
- 4-(4-Chlorophenoxy)aniline
- Purity
- 97%
- Packaging
- 25g
- Price
- $215
- Updated
- 2023/01/07
- Product number
- C1069
- Product name
- 4-Amino-4'-chlorodiphenyl Ether
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $44
- Updated
- 2025/07/31
- Product number
- C1069
- Product name
- 4-Amino-4'-chlorodiphenyl Ether
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $150
- Updated
- 2025/07/31
- Product number
- FA10728
- Product name
- 4-Amino-4'-chlorodiphenyl ether
- Packaging
- 250g
- Price
- $875
- Updated
- 2021/12/16
4-Amino-4'-chlorodiphenyl ether Chemical Properties,Usage,Production
Chemical Properties
Dark powder
Uses
It is used as an active pharmaceutical intermediate.
Synthesis
1836-74-4
101-79-1
General procedure for the synthesis of 4'-chloro-4-amino-diphenyl ether from 4'-chloro-4-nitro-diphenyl ether: general method: 1-substituted-4-nitrobenzene (9.3 mmol) and hydrazine hydrate (27.9 mmol) were dissolved in 20 mL of ethanol, and stirred for 10 min at 28-30°C. The reaction was carried out in aqueous suspension of Raney-Ni (0.02 g). An aqueous suspension of Raney-Ni (0.02 g, 4.41 mL) was added in three 10-min intervals. after 30 min, the reaction was allowed to plateau, and the temperature was raised to 50-60 °C to continue stirring for 6 h. The catalyst was removed by filtration. After completion of the reaction, the catalyst was removed by filtration. The solvent was removed by evaporation to give the target product 4'-chloro-4-amino-diphenyl ether.
References
[1] Green Chemistry, 2017, vol. 19, # 14, p. 3400 - 3407
[2] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 7, p. 1588 - 1592
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 11, p. 4811 - 4815
[4] Pharmazie, 1980, vol. 35, # 2, p. 78 - 80
[5] Pharmazie, 1980, vol. 35, # 2, p. 78 - 80
4-Amino-4'-chlorodiphenyl ether Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Amino-4'-chlorodiphenyl ether manufacturers
- Product
- 4-Amino-4'-chlorodiphenyl ether 101-79-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg,5kg,100kg
- Release date
- 2019-07-04