NITROFEN
- Product Name
- NITROFEN
- CAS No.
- 1836-75-5
- Chemical Name
- NITROFEN
- Synonyms
- NIP;toke;2,4-DICHLORO-1-(4-NITROPHENOXY)BENZENE;benzene,2,4-dichloro-1-(4-nitrophenoxy)-;TOK;fw925;tok-2;FW 925;toke40;TOK(R)
- CBNumber
- CB9103795
- Molecular Formula
- C12H7Cl2NO3
- Formula Weight
- 284.09
- MOL File
- 1836-75-5.mol
NITROFEN Property
- Melting point:
- 69-70°C
- Boiling point:
- 368 ºC
- Density
- 1.3
- refractive index
- 1.6140 (estimate)
- Flash point:
- 205℃
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- Solid
- color
- White to Light yellow
- biological source
- human blood
- Water Solubility
- 1mg/L(22 ºC)
- Merck
- 14,6598
- BRN
- 1887356
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- NIST Chemistry Reference
- 2,4-Dichloro-4'-nitrodiphenyl ether(1836-75-5)
- IARC
- 2B (Vol. 30, Sup 7) 1987
- EPA Substance Registry System
- Nitrofen (1836-75-5)
Safety
- Hazard Codes
- T,N
- Risk Statements
- 45-61-50/53-22
- Safety Statements
- 45-53-61-60-50/53-22
- RIDADR
- 3077
- WGK Germany
- 3
- RTECS
- KN8400000
- TSCA
- Yes
- HazardClass
- 9
- PackingGroup
- III
- HS Code
- 29093090
- Hazardous Substances Data
- 1836-75-5(Hazardous Substances Data)
- Toxicity
- LD50 orally in rats: 3.58 g/kg (Ambrose)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H350May cause cancer
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P273Avoid release to the environment.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- CRM63613
- Product name
- Nitrofen
- Purity
- certified reference material, <I>Trace</I><B>CERT</B><SUP>®</SUP>, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
- Packaging
- 100 mg
- Price
- $151
- Updated
- 2025/07/31
- Product number
- CB_85102916
- Product name
- TOKUNAGA human cell line
- Purity
- IHW Number: 9304, NOTE: Both the cell line and DNA from the cell line may be available for this product. Please choose -1VL or VIAL for cells, or -DNA-5UG for DNA., 85102916
- Packaging
- 1 unit
- Price
- $402
- Updated
- 2025/07/31
- Product number
- CB_85102916
- Product name
- TOKUNAGA human cell line
- Purity
- IHW Number: 9304, NOTE: Both the cell line and DNA from the cell line may be available for this prod
- Packaging
- 1 unit
- Price
- $402
- Updated
- 2025/07/31
- Product number
- CB_85102916
- Product name
- TOKUNAGA human cell line
- Purity
- 85102916, IHW Number: 9304
- Packaging
- 1VIAL
- Price
- $563
- Updated
- 2025/07/31
- Product number
- 33374
- Product name
- Nitrofen
- Purity
- PESTANAL
- Packaging
- 100mg
- Price
- $68
- Updated
- 2025/07/31
NITROFEN Chemical Properties,Usage,Production
Chemical Properties
Nitrofen is a crystalline solid.
Uses
Formerly as herbicide.
Definition
ChEBI: Nitrofen is an organic molecular entity. It has a role as an EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor and a herbicide.
General Description
Colorless crystals or black solid. Used as a pre- or post-emergence herbicide.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
NITROFEN is a nitrated and halogenated ether derivative.
Health Hazard
Nitrofen is moderately toxic by ingestionand inhalation of dusts. The lethal doses in cats from oral administration and inhalationof dusts are 300 mg/kg and 620 mg/m3/4h,respectively (NIOSH 1986). Bovine calvestreatedorally by 1.5 mL 25% nitrofen/kg produced toxic effects after 36–48 hours. Thesymptoms were increase in body temperature, depression, and progressive decrease inrespiration rate and pulse rate,similar to tribulin (Gupta and Singh 1985). An increase inthe activities of serum glutamic-oxaloacetictransaminase and glutamipyruvictransaminase was noted(Gupta and Singh 1984). Nitrofen has beenfound to cause cancer in animals. There issufficient evidence of its carcinogenicity inanimals (IARC). Oral administration in micecaused liver and lung cancers.
Fire Hazard
Flash point data for NITROFEN are not available; however, NITROFEN is probably combustible.
Safety Profile
Confirmed carcinogen with experimental carcinogenic data. Poison by ingestion. Moderately toxic by inhalation and possibly other routes. Experimental teratogenic and reproductive effects. A skin and severe eye irritant. Mutation data reported. A broad-spectrum herbicide. See also NITRO COMPOUNDS of AROMATIC HYDROCARBONS and ETHERS. When heated to decomposition it emits very toxic fumes of Cl and NOx.
Synthesis
350-46-9
120-83-2
1836-75-5
GENERAL METHOD: A dispersion of 0.69 g (17.3 mmol) of 60% NaH in mineral oil was washed with hexane and subsequently suspended in 20 mL of DMF. A solution of 2,4-dichlorophenol (12.9 mmol) in DMF (20 mL) was added slowly and dropwise. After stirring for 1 hour at room temperature, a DMF (4 mL) solution of p-fluoronitrobenzene (1.5 g, 10.3 mmol) was added. Stirring was continued at room temperature for 1 h. The reaction mixture was then warmed up to 50 °C and maintained for 12 h. The reaction mixture was then heated up to 50 °C. Upon completion of the reaction, the reaction was quenched with saturated NH4Cl solution. The mixture was extracted with ether and the organic layer was washed sequentially with 0.2 M NaOH solution until the aqueous layer was colorless, then with 1 M HCl and saturated brine solution. The organic layer was dried over anhydrous MgSO4, concentrated in vacuum and finally purified by column chromatography using hexane-ethyl acetate (5:1) as eluent to afford the target product 2',4'-dichloro-4-nitro-diphenyl ether.
Potential Exposure
Nitrofen is a contact herbicide used for pre-and post-emergency control of annual grasses and broadleaf weeds on a variety of food and ornamental crops. Occupational exposure to nitrofen, primarily through inhalation and dermal contact may occur among workers at production facilities. Field handlers of the herbicide are subject to inhalation exposure during application procedures.
Carcinogenicity
Nitrofen is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Shipping
UN3345 Phenoxyacetic acid derivative pesticide, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard Class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.
Waste Disposal
Small quantities may be landfilled but large quantities should be incinerated. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.
References
[1] Canadian Journal of Chemistry, 2015, vol. 94, # 1, p. 95 - 104
[2] European Journal of Organic Chemistry, 2011, # 8, p. 1587 - 1592
[3] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 7, p. 1588 - 1592
[4] New Journal of Chemistry, 2015, vol. 39, # 9, p. 7281 - 7292
[5] European Journal of Medicinal Chemistry, 2016, vol. 113, p. 273 - 292
NITROFEN Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from NITROFEN manufacturers
- Product
- NITROFEN 1836-75-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2019-12-31