NOBILETIN

ChemicalBook > CAS DataBase List > NOBILETIN

Description Source Uses structure and hydrogen bonding Application

Product Name: NOBILETIN
CAS No.: 478-01-3
Chemical Name: NOBILETIN
Synonyms: hexamethoxyflavone;Chuanpi glycosides;biletin;Nobiletin, 98%, from Citrus nobilis Lour.;NOBILETIN;Nobiletin>Chuanchenpi Su;Nobiletin (6CI);Nobiletin, >=98%;Nobiletin 478-01-3
CBNumber: CB3740677
Molecular Formula: C21H22O8
Formula Weight: 402.39
MOL File: 478-01-3.mol

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NOBILETIN Property

Melting point:: 136.0 to 140.0 °C
Boiling point:: 587.9±50.0 °C(Predicted)
Density: 1.244±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Soluble in DMSO (up to 10 mg/ml)
color: White
BRN: 360887
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey: MRIAQLRQZPPODS-UHFFFAOYSA-N
CAS DataBase Reference: 478-01-3(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
WGK Germany: 3
RTECS: DJ3052200
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N1538
Product name: Nobiletin
Purity: ≥97%
Packaging: 5mg
Price: $358
Updated: 2024/03/01

Sigma-Aldrich

Product number: N1538
Product name: Nobiletin
Purity: ≥97%
Packaging: 10mg
Price: $592
Updated: 2024/03/01

TCI Chemical

Product number: N0871
Product name: Nobiletin
Purity: >95.0%(HPLC)
Packaging: 10mg
Price: $158
Updated: 2024/03/01

TCI Chemical

Product number: N0871
Product name: Nobiletin
Purity: >95.0%(HPLC)
Packaging: 100mg
Price: $866
Updated: 2024/03/01

Cayman Chemical

Product number: 15421
Product name: Nobiletin
Purity: ≥98%
Packaging: 5mg
Price: $36
Updated: 2024/03/01

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NOBILETIN Chemical Properties,Usage,Production

Description

Nobiletin (NOB) chemically known as 5,6,7,8,3′,4′-hexamethoxyflavone is a dietary polymethoxylated flavonoid found in Citrus fruits. Nobiletin is a flavonoid isolated from citrus peels. It is an O-methylated flavone that has the activity to rescue bulbectomy-induced memory impairment.

Source

Nobiletin is a nonpolar polymethoxylated flavone (PMFs) found in the citrus peel of various fruits, such as tangerine. Its chemical structure is similar to tangeretin, containing the typical flavonoid structure and six methoxyl groups (one more than tangeretin).

Uses

NOB is a multifunctional pharmaceutical agent. The various pharmacological activities of NOB include neuroprotection, cardiovascular protection, antimetabolic disorder, anticancer, anti-inflammation, and antioxidation.

structure and hydrogen bonding

The crystal structure study on NOB shows that the chromene and the arene rings are almost in the same plane. The C atoms of the two methoxy groups in the arene ring are also in the same plane, while the C atoms of four methoxy groups linking to the chromene ring are not in parallel. This conformational characteristic of chiral structure is indicated by the covalent bond rotation between the arene and the chromene rings and the conformational alternations of methoxy groups.

Application

Nobiletin has been shown to exhibit antioxidant, anti-inflammatory, antitumor/cancer, and antiangiogenic activity in vitro and in vivo. Animal and in vitro data also demonstrate nobiletin's potential ability to suppress bone loss, lower cholesterol and atherosclerosis, and improve hyperglycemia and insulin resistance.

Description

Nobiletin (478-01-3) is a natural product isolated from citrus peels.? It has recently been shown to possess circadian clock amplitude-enhancing properties and was able to prevent metabolic syndrome in mice?via?a?Clock?gene-dependent mechanism.1? Nobiletin directly bound to and activated RORα/γ.? Nobiletin has previously been shown to attenuate the effects of metabolic syndrome2, have anti-neuroinflammatory effects3, possess neurotrophic activity4, and be a cancer chemopreventative agent5.

Chemical Properties

White powder

Uses

matrix metaloproteinase inhibitor; antineoplastic

Uses

Nobiletin is an O-methylated flavone, a flavonoid isolated from citrus peels like in tangerine. It is a potent antioxidant with good bioavailability. Nobiletin directly inhibits the ATP-binding cassette proteins P-glycoprotein and breast cancer resistance protein.

Definition

ChEBI: A methoxyflavone that is flavone substituted by methoxy groups at positions 5, 6, 7, 8, 3' and 4' respectively.

benefits

Nobiletin improved cognitive deficits and the pathological features of AD, such as Aβ pathology, hyperphosphorylation of tau, and oxidative stress, in animal models of AD. In addition, nobiletin improved motor and cognitive deficits in PD animal models. These observations suggest that nobiletin has the potential to become a novel drug for the treatment and prevention of neurodegenerative diseases such as AD and PD.

References

1) He?et al.?(2016),?The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome; Cell Metabolism,?23?610 2) Mulvihill?et al.?(2011),?Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance; Diabetes?60?1446 3) Cui?et al.?(2010),?Anti-neuroinflammatory activity of nobiletin on suppression of microglial activation; Biol. Pharm. Bull.,?33?1814 4) Nagase?et al.?(2005),?Mechanism of neurotrophic action of nobiletin in PC12D cells; Biochemistry?44?13683 5) Walle (2007),?Methoxylated flavones, a superior cancer chemopreventative flavonoid subclass?;?Semin. Cancer Biol.?17?354

NOBILETIN Preparation Products And Raw materials

Raw materials

Preparation Products

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NOBILETIN Suppliers

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View Lastest Price from NOBILETIN manufacturers

Sinoway Industrial co., ltd.

Product: Nobiletin 478-01-3
Price: US $235.00-55.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 98% up,
Supply Ability: 20 tons
Release date: 2023-12-29

Changsha Staherb Natural Ingredients Co., Ltd.

Product: NOBILETIN 478-01-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98% HPLC
Supply Ability: 1000kg
Release date: 2022-11-21

Chongqing Zhihe Biopharmaceutical Co., Ltd.

Product: NOBILETIN 478-01-3
Price: US $0.00-0.00/kg
Min. Order: 0.10000000149011612kg
Purity: ≥98%
Supply Ability: 20tons
Release date: 2024-01-05

478-01-3, NOBILETINRelated Search:

2,3-Dimethoxy-5-methyl-1,4-hydroquinone 3',4',5,7-TETRAMETHOXYFLAVONE 7,8-DIMETHOXYFLAVONE 6,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE 5-DEMETHYLNOBILETIN 2,3,4-Trimethoxyphenol Wogonin 3',4',7,8-TETRAHYDROXYFLAVONE GARDENIN B 2,3,4,5-Tetramethoxytoluene 5,7,8-TRIHYDROXYFLAVONE Nobiletin LYSIONOTIN 1,2,3,4-TETRAMETHOXYBENZENE 6-METHOXYLUTEOLIN NOBILETIN(P) FLAVONE PEDALITIN

biletin

Nobiletin, 98%, from Citrus nobilis Lour.

Nobiletin, froM Citrus nobilis Lour.

Chuanpi glycosides

4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-

Nobiletin, >=98%

NOBILETIN

3',4',5,6,7,8-HEXAMETHOXYFLAVONE

NOBILETIN WITH HPLC

NOBILETIN, 20% (TECHNICAL GRADE)

4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-

5,6,7,8-tetramethoxy-

Nobiletin，Hexamethoxyflavone

2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one

2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-chromen-4-one

2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one

2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-chromone

Flavone, 5,6,7,8,3',4'-hexamethoxy

hexamethoxyflavone

Nobiletin 478-01-3

Nobiletin&gt

Nobiletin (100 mg) (2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-chromen-4-one)

Polymethoxylated Flavones (PMFs)

2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-chromen-4-one

Nobiletin (6CI)

Chuanchenpi Su

478-01-3

C21H22O8

chemical reagent

pharmaceutical intermediate

CITRIMORE

Inhibitors

natural product

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Hexa-substituted Flavones

478-01-3