ChemicalBook > CAS DataBase List > 2,5-DIMETHOXYBENZONITRILE

2,5-DIMETHOXYBENZONITRILE

Product Name: 2,5-DIMETHOXYBENZONITRILE
CAS No.: 5312-97-0
Chemical Name: 2,5-DIMETHOXYBENZONITRILE
Synonyms: Einecs 226-169-2;2,5-DIMETHOXYBENZONI;2,5-DIMETHOXYBENZONITRILE;Benzonitrile, 2,5-dimethoxy-;2,5-Dimethoxybenzonitrile>2-cyanohydroquinone dimethyl ether
CBNumber: CB3740819
Molecular Formula: C9H9NO2
Formula Weight: 163.17
MOL File: 5312-97-0.mol

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2,5-DIMETHOXYBENZONITRILE Property

Melting point:: 81-85 °C (lit.)
Boiling point:: 288.8±25.0 °C(Predicted)
Density: 1.12±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
color: White to Yellow to Orange
BRN: 2691937
CAS DataBase Reference: 5312-97-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37
RIDADR: 3276
WGK Germany: 3
HazardClass: 6.1
PackingGroup: III
HS Code: 29269090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 594776
Product name: 2,5-Dimethoxybenzonitrile
Purity: 97%
Packaging: 5g
Price: $224
Updated: 2023/06/20

TCI Chemical

Product number: D3659
Product name: 2,5-Dimethoxybenzonitrile
Purity: >98.0%(GC)
Packaging: 1g
Price: $25
Updated: 2025/07/31

TCI Chemical

Product number: D3659
Product name: 2,5-Dimethoxybenzonitrile
Purity: >98.0%(GC)
Packaging: 5g
Price: $70
Updated: 2025/07/31

TRC

Product number: D525963
Product name: 2,5-Dimethoxybenzonitrile
Packaging: 250mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD64139
Product name: 2,5-Dimethoxybenzonitrile
Packaging: 2g
Price: $50
Updated: 2021/12/16

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2,5-DIMETHOXYBENZONITRILE Chemical Properties,Usage,Production

Synthesis

68-12-2

150-78-7

5312-97-0

At 0 °C, n-butyllithium (1.67 M hexane solution, 2.9 mL, 4.8 mmol) was slowly added dropwise to a solution of 1,3-dimethoxybenzene (0.55 g, 4.0 mmol) in tetrahydrofuran (5 mL). The reaction mixture was stirred continuously at 0 °C for 2 hours. Subsequently, N,N-dimethylformamide (0.34 mL, 4.4 mmol) was added to the mixture and stirring was continued for 2 hours at 0 °C. Upon completion of the reaction, ammonia solution (8 mL, 120 mmol) and iodine (1.12 g, 4.4 mmol) were added and the mixture was transferred to room temperature and stirred for 2 hours. The reaction mixture was quenched with saturated aqueous sodium sulfite solution (15 mL) and extracted several times with ether (3 x 20 mL). The organic layers were combined, washed with saturated saline and dried over anhydrous sodium sulfate to give the crude product 2,6-dimethoxybenzonitrile with a purity of over 80%. The crude product was purified by silica gel short-column chromatography (eluent: hexane/ethyl acetate=3:1) to afford pure 2,6-dimethoxybenzonitrile as a colorless solid in 91% yield.

References

[1] Synlett, 2010, # 10, p. 1562 - 1566
[2] Tetrahedron, 2011, vol. 67, # 5, p. 958 - 964

2,5-DIMETHOXYBENZONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,5-DIMETHOXYBENZONITRILE manufacturers

Career Henan Chemical Co

Product: 2,5-DIMETHOXYBENZONITRILE 5312-97-0
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg,5kg,50kg
Release date: 2020-01-18

5312-97-0, 2,5-DIMETHOXYBENZONITRILERelated Search:

2,5-DIMETHOXYBENZONITRILE

2-cyanohydroquinone dimethyl ether

Einecs 226-169-2

2,5-DIMETHOXYBENZONI

2,5-Dimethoxybenzonitrile&gt

Benzonitrile, 2,5-dimethoxy-

5312-97-0

Nitrogen Compounds

Organic Building Blocks

Cyanides/Nitriles

Building Blocks

C8 to C9

Aromatic Nitriles

Anisoles, Alkyloxy Compounds & Phenylacetates

Nitriles

C8 to C9

Cyanides/Nitriles

Nitrogen Compounds