2,5-DIMETHOXYBENZONITRILE
- Product Name
- 2,5-DIMETHOXYBENZONITRILE
- CAS No.
- 5312-97-0
- Chemical Name
- 2,5-DIMETHOXYBENZONITRILE
- Synonyms
- Einecs 226-169-2;2,5-DIMETHOXYBENZONI;2,5-DIMETHOXYBENZONITRILE;Benzonitrile, 2,5-dimethoxy-;2,5-Dimethoxybenzonitrile>2-cyanohydroquinone dimethyl ether
- CBNumber
- CB3740819
- Molecular Formula
- C9H9NO2
- Formula Weight
- 163.17
- MOL File
- 5312-97-0.mol
2,5-DIMETHOXYBENZONITRILE Property
- Melting point:
- 81-85 °C (lit.)
- Boiling point:
- 288.8±25.0 °C(Predicted)
- Density
- 1.12±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- color
- White to Yellow to Orange
- BRN
- 2691937
- CAS DataBase Reference
- 5312-97-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 594776
- Product name
- 2,5-Dimethoxybenzonitrile
- Purity
- 97%
- Packaging
- 5g
- Price
- $224
- Updated
- 2023/06/20
- Product number
- D3659
- Product name
- 2,5-Dimethoxybenzonitrile
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $25
- Updated
- 2025/07/31
- Product number
- D3659
- Product name
- 2,5-Dimethoxybenzonitrile
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $70
- Updated
- 2025/07/31
- Product number
- D525963
- Product name
- 2,5-Dimethoxybenzonitrile
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 4637-1-U9
- Product name
- 2,5-Dimethoxybenzonitrile
- Packaging
- 2.5g
- Price
- $38
- Updated
- 2021/12/16
2,5-DIMETHOXYBENZONITRILE Chemical Properties,Usage,Production
Synthesis
68-12-2
150-78-7
5312-97-0
At 0 °C, n-butyllithium (1.67 M hexane solution, 2.9 mL, 4.8 mmol) was slowly added dropwise to a solution of 1,3-dimethoxybenzene (0.55 g, 4.0 mmol) in tetrahydrofuran (5 mL). The reaction mixture was stirred continuously at 0 °C for 2 hours. Subsequently, N,N-dimethylformamide (0.34 mL, 4.4 mmol) was added to the mixture and stirring was continued for 2 hours at 0 °C. Upon completion of the reaction, ammonia solution (8 mL, 120 mmol) and iodine (1.12 g, 4.4 mmol) were added and the mixture was transferred to room temperature and stirred for 2 hours. The reaction mixture was quenched with saturated aqueous sodium sulfite solution (15 mL) and extracted several times with ether (3 x 20 mL). The organic layers were combined, washed with saturated saline and dried over anhydrous sodium sulfate to give the crude product 2,6-dimethoxybenzonitrile with a purity of over 80%. The crude product was purified by silica gel short-column chromatography (eluent: hexane/ethyl acetate=3:1) to afford pure 2,6-dimethoxybenzonitrile as a colorless solid in 91% yield.
References
[1] Synlett, 2010, # 10, p. 1562 - 1566
[2] Tetrahedron, 2011, vol. 67, # 5, p. 958 - 964
2,5-DIMETHOXYBENZONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
2,5-DIMETHOXYBENZONITRILE Suppliers
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View Lastest Price from 2,5-DIMETHOXYBENZONITRILE manufacturers
- Product
- 2,5-DIMETHOXYBENZONITRILE 5312-97-0
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg,5kg,50kg
- Release date
- 2020-01-18