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NEUROPEPTIDE FF

Product Name
NEUROPEPTIDE FF
CAS No.
99566-27-5
Chemical Name
NEUROPEPTIDE FF
Synonyms
NPFF;NPAF;ninamide;F-8-F-NH2;FLFQPQRF-NH2;NEUROPEPTIDE FF;Neuropeptide FF TFA;Neuropeptide FF (cattle);Neuropeptide FF F-8-F-NH2;NEUROPEPTIDE FF USP/EP/BP
CBNumber
CB3750458
Molecular Formula
C54H76N14O10
Formula Weight
1081.27
MOL File
99566-27-5.mol
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NEUROPEPTIDE FF Property

storage temp. 
−20°C
solubility 
Water: 1 mg/ml
form 
Solid
color 
White to off-white
Water Solubility 
Soluble to 0.50 mg/ml in water.
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J66509
Product name
Neuropeptide FF
Packaging
1mg
Price
$58.2
Updated
2023/06/20
Cayman Chemical
Product number
24548
Product name
Neuropeptide FF (trifluoroacetate salt)
Purity
≥95%
Packaging
1mg
Price
$158
Updated
2024/03/01
Tocris
Product number
3137
Product name
Neuropeptide FF
Packaging
1
Price
$162
Updated
2021/12/16
Usbiological
Product number
027103
Product name
Neuropeptide FF
Packaging
96Tests
Price
$864
Updated
2021/12/16
Usbiological
Product number
027102
Product name
Neuropeptide FF
Packaging
96Tests
Price
$879
Updated
2021/12/16
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NEUROPEPTIDE FF Chemical Properties,Usage,Production

Description

Neuropeptide FF (NPFF) is a peptide expressed in the brain and spinal cord that shares a precursor protein with neuropeptide AF. NPFF is expressed primarily in the posterior pituitary, hypothalamus, and medulla. It is an agonist at NPFF1 and NPFF2 receptors (Kis = 2.82 and 0.21 nM, respectively, for human recombinant receptors) that inhibits forskolin-induced cAMP production in CHO cells (EC50s = 236 and 2.3 nM, respectively). NPFF activates parvocellular neurons in the paraventricular nucleus (PVN) of the hypothalamus to stimulate oxytocin release from their projections in the brain stem, thereby regulating baroreflex control of heart rate. However, it inhibits magnocellular PVN neurons by enhancing GABAergic input. It is also found in plasma and exogenous administration briefly increases mean arterial pressure (MAP) by 40 mm Hg in rats, an effect that is only partially blocked by the norepinephrine competitor guanethidine and the α1-adrenergic receptor antagonist prazosin . NPFF has anti-opioid effects in rodent models, inhibiting morphine-induced analgesia and inducing abstinence in morphine-tolerant rats. It also inhibits acquisition of conditioned place preference to cocaine in rats when administered at doses of 10 and 20 nmol.

Uses

Endogenous antiopioid peptide and agonist at NPFF1 and NPFF2 receptors (Ki values are 2.82 and 0.21 nM respectively). Exhibits anorexigenic effects.

storage

Store at -20°C

NEUROPEPTIDE FF Preparation Products And Raw materials

Raw materials

Preparation Products

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NEUROPEPTIDE FF Suppliers

China 83 France 1 Germany 1 Switzerland 1 United Kingdom 3 United States 14 USA 1 Global 104
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77
Fluorochem Ltd
Tel
--
Fax
--
Email
vernam@fluorochem.co.uk
Country
United Kingdom
ProdList
6375
Advantage
65
Fluorochem Ltd.
Tel
--
Fax
--
Email
enquiries@fluorochem.co.uk
Country
United Kingdom
ProdList
6401
Advantage
74
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View Lastest Price from NEUROPEPTIDE FF manufacturers

Career Henan Chemical Co
Product
NEUROPEPTIDE FF 99566-27-5
Price
US $1.00/g
Min. Order
1g
Purity
≥98%
Supply Ability
g/kg/Ton
Release date
2020-03-05

99566-27-5, NEUROPEPTIDE FFRelated Search:

NEUROPEPTIDE AF (HUMAN) NEUROPEPTIDE Y (13-36), PORCINE SYNTHETI C >97% PANCREATIC POLYPEPTIDE, RAT SUBSTANCE P (2-11) SUBSTANCE P (6-11) Substance P (1-7)(TFA) substance P (3-11) (LEU31,PRO34)-NEUROPEPTIDE Y (HUMAN, RAT) Calcitonin Gene Related Peptide (CGRP) (83-119), rat TFA Galanin (1-16), mouse, porcine, rat TFA NEUROPEPTIDE F GALANIN, PORCINE GLY-LEU-MET-NH2 H-ALA-ARG-TYR-TYR-SER-ALA-LEU-ARG-HIS-TYR-ILE-ASN-LEU-ILE-THR-ARG-GLN-ARG-TYR-NH2 H-LEU-PRO-GLY-LEU-PRO-SER-ALA-ALA-SER-SER-GLU-ASP-ALA-GLY-GLN-SER-NH2 SUBSTANCE P (1-9) SUBSTANCE P NEUROPEPTIDE Y (HUMAN, RAT)

  • PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE AMIDE
  • PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE-NH2
  • NPFF
  • NEUROPEPTIDE FF
  • H-PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE-NH2
  • F-8-F-NH2
  • ninamide
  • phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylala
  • POTASSIUM FERROCYANIDE TRIHYDRATE*ACS RE AGENT
  • Neuropeptide FF F-8-F-NH2
  • phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide
  • Neuropeptide FF Morphine Modulating Neuropeptide F-8-F-NH2
  • Neuropeptide FF F-8-F-NH2, NPFF, F-8-F-aMide
  • F-8-F-NH2, NPFF, F-8-F-aMide
  • ANTI-NPFF (C-TERM) antibody produced in rabbit
  • FMRFamide-related peptides
  • NPAF
  • Neuropeptide FF (trifluoroacetate salt)
  • L-Phenylalaninamide, L-phenylalanyl-L-leucyl-L-phenylalanyl-L-glutaminyl-L-prolyl-L-glutaminyl-L-arginyl-
  • Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe amide >=95% (HPLC)
  • NEUROPEPTIDE FF USP/EP/BP
  • Neuropeptide FF (cattle)
  • FLFQPQRF-NH2
  • Neuropeptide FF trifluoroacetate salt (NPFF)
  • Neuropeptide FF TFA
  • Rabbit Anti-NPFF antibody
  • 99566-27-5
  • C54H76N14O10
  • BioChemical
  • Amino Acids and Peptides
  • Biochemicals and Reagents
  • Other Peptides
  • Peptides
  • Peptide